Chromosomal characteristics of chronic and blastic phases of Ph-positive chronic myeloid leukemia

Sadamori, Naoki; Matsunaga, Masako; Yao, Ei-ichi; Ichimaru, Michito; Sandberg, Avery A.

doi:10.1016/0165-4608(85)90127-x

Cited by 39 publications

(18 citation statements)

References 23 publications

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“…First, it was reported many years ago that persons with chronic phase CML at diagnosis may have CML cells with cytogenetic abnormalities consistent with acute phase. 2 This is conceptually consistent with recent data from ultra-deep sequencing of the BCR/ABL tyrosine kinase domain in persons with chronic phase CML, where many mutations are identified before drug exposure. 3 These data suggest a long latency from acquisition of BCR/ABL to diagnosis of chronic phase CML.…”

supporting

confidence: 90%

Transmission of CML or of t(9; 22) and BCR/ABL? They are not the same

Gale

Apperley

2015

Bone Marrow Transplant

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supporting

confidence: 90%

Transmission of CML or of t(9; 22) and BCR/ABL? They are not the same

Gale

Apperley

2015

Bone Marrow Transplant

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“…However, these abnormalities might have oc curred before the BP. A relationship between the short survival and lq abnormalities has been found in previous reports [1,7], According to Sadamori et al [10], the chromosome patterns in the BP of CML are of the complex type. These changes would, therefore, represent the cyto genetic evidence of an advanced phase of the disease.…”

Section: Discussionmentioning

confidence: 67%

“…The occurrence of i( 17q) is thought to be a bad prognostic omen, related to the BP, although this ab normality has been sometimes found during the chronic phase [10]. In case 1, the i( 17q) abnormality was observed only during the BP in 100% of the cells.…”

Section: Discussionmentioning

confidence: 99%

“…Such ab normalities consist of acquisitions, losses and/or structural rearrangements involving some particular chromosomes. The blastic phase (BP) is frequently ac companied by karyotypic changes following nonran dom patterns of evolution [11], During the BP, the in cidence of chromosomal abnormalities in addition to Ph translocation is very high: it occurs in 75-90% of the patients [10,11,13]. Patients without additional abnormalities show a better prognosis, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Beside these 'major' chromosomal changes, other additional aberrations are observed. Generally, these complex chromosomal changes are exclusively related to the BP [10]. Some questions as to the involvement of different chromosomes in addi tion to those frequently affected throughout the course of CML still remain unsolved.…”

Section: Introductionmentioning

confidence: 99%

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t(1 ;2), inv(1) and Trisomy 1q during the Blastic Phase of Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

et al. 1987

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Several karyotype changes observed during the blastic phase in 2 patients with Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML) are reported. Rearrangements involving chromosome 1, i.e., translocations, a pericentric inversion and trisomies of its long arm, are described. In the first patient whose chronic phase was very long (17 years), the uncommon association between i(17q) and Ph duplication has been observed during the blastic phase, beside the involvement of chromosome 1. In the second patient, additional abnormalities involving chromosomes 1, 2, 4, 8, 18 and 21 were present. Of particular interest is the finding of a t(1;2). In this case, the presence of hyperdiploid cells with 49–50 chromosomes, prevailing at the blastic crisis, was due to the evolution of the hypodiploid clone with the 45, XX, t(9;22),-21 karyotype found during the chronic phase. The occurrence of chromosomal changes involving chromosome 1 during the blastic phase of CML is emphasized.

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