Chromosomal Evolution in Mole Voles Ellobius (Cricetidae, Rodentia): Bizarre Sex Chromosomes, Variable Autosomes and Meiosis

Matveevsky, Sergey; Коломиец, О. Л.; Bogdanov, A. S.; Hakhverdyan, Mikhayil; Bakloushinskaya, Irina

doi:10.3390/genes8110306

Cited by 27 publications

(34 citation statements)

References 82 publications

(124 reference statements)

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“…Namely, the lineage examined by Srikulnath et al [2014] might have experienced a sex chromosome turnover, leading to the loss of the original lacertid sex chromosome system and appearance of a new system, based on another chromosome pair. The cases of such turnovers, when a taxon "forsakes" a well-established sex chromosome system and acquires a new one, are rather rare , but known in lizards [Nielsen et al, 2019] and even in mammals [Matveevsky et al, 2017]. An intraspecific polymorphism in sex-determining systems is also possible, as in the case of the frog Glandirana rugosa [Ogata et al, 2018].…”

mentioning

confidence: 99%

Chromosome Painting Does Not Support a Sex Chromosome Turnover in Lacerta agilis Linnaeus, 1758

Lisachov

Giovannotti

Pereira

et al. 2020

Cytogenet Genome Res

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Reptiles show a remarkable diversity of sex determination mechanisms and sex chromosome systems, derived from different autosomal pairs. The origin of the ZW sex chromosomes of Lacerta agilis, a widespread Eurasian lizard species, is a matter of discussion: is it a small macrochromosome from the 11-18 group common to all lacertids, or does this species have a unique ZW pair derived from the large chromosome 5? Using independent molecular cytogenetic methods, we investigated the karyotype of L. agilis exigua from Siberia, Russia, to identify the sex chromosomes. FISH with a flow-sorted chromosome painting probe derived from L. strigata and specific to chromosomes 13, 14, and Z confirmed that the Z chromosome of L. agilis is a small macrochromosome, the same as in L. strigata. FISH with the telomeric probe showed an extensive accumulation of the telomere-like repeat in the W chromosome in agreement with previous studies, excluding the possibility that the lineages of L. agilis studied in different works could have different sex chromosome systems due to a putative intra-species polymorphism. Our results reinforce the idea of the stability of the sex chromosomes and lack of evidence for sex-chromosome turnovers in known species of Lacertidae.

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mentioning

confidence: 99%

Chromosome Painting Does Not Support a Sex Chromosome Turnover in Lacerta agilis Linnaeus, 1758

Lisachov

Giovannotti

Pereira

et al. 2020

Cytogenet Genome Res

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“…Later, W. Just and colleagues attempted to detect this gene in the genomic DNA of E. lutescens males using Sry probes of distinct species, changing hybridization conditions, etc., but got no specific signal [55]. Recently [56], we re-checked all five species (E. alaicus was unstudied before) and obtained unexpected results. In accordance with previous studies, we did not identify any Srysimilar sequences for males and females of E. lutescens, E. talpinus, Е. tancrei, and, for the first time, E. alaicus.…”

Section: In Search Of a Primary Switch For Mole Volesmentioning

confidence: 96%

“…Although the genes Eif2s3y, Zfy, and Ssty were identified in males and females, the expression of these genes was detected in testes only. We sequenced fragments of the Eif2s3y of all Ellobius species, both males and females, and revealed, that an exonic part of Eif2s3y was demonstrated to identify up to 88% with the gene described for T. muenninki, a species with a Y chromosome [56]. The non-exonic sequenced part was highly variable compared to Ellobius species but was identical in males and females for each species.…”

Section: The Loss Of a Y Chromosome Is Not A Deadlockmentioning

confidence: 96%

“…E. fuscocapillus develops a classical system for Eutherians, with a large submetacentric X chromosome and a small acrocentric Y. In the middle pachytene, Y achieved a complete synapsis with X and quickly underwent early complete desynapsis during the late pachytene-early diplotene [42,45,56]. Early desynapsis is uncommon for mammals and might be a sign of the lack of recombination, and further studies are needed.…”

Section: X0 and XX Sex Chromosomes In Meiosismentioning

confidence: 99%

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Unusual Ways to Lose a Y Chromosome and Survive with Changed Autosomes: a Story of Mole Voles Ellobius (Mammalia, Rodentia)

Bakloushinskaya¹,

Matveevsky²

2018

obm genet

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Species of mole volesEllobius demonstrate a broad variation in sex chromosomes and autosomes, which is unique among mammals. In four species, a Y chromosome was lost, and X0 or XX sex chromosomes in both sexes were obtained. The key testis-determining Sry (Sexdetermining Region on Y) gene is absent in these species, and the regulation of its target, the Sox9 (SRY -box 9) gene, is questionable due to deletion in the key enhancer. In a single species, E. fuscocapillus, with routine XX-XY, the same deletion is present alongside fragments of Sry in the female genome. Presumably, a Y chromosome was lost twice in two phylogenetic lineages of mole rats; before the event, a few male-specific genes escaped on X chromosomes. Translocations of Y chromosome fragments were made independently, resulting in different changes in species without a Y chromosome and the presence of the Ylinked Sry gene in females of E. fuscocapillus, a species retaining the Y chromosome. One more exceptional phenomenon is high autosomal variability in E. tancrei. This species might be used as an exclusive model for studying meiotic mechanisms providing balanced gametes in complex heterozygous hybrids. Sterility is the only destiny for hybrids, whose parents carry Robertsonian translocations with partial homology. Contrary to that, E. tancrei possess different Robertsonian translocations and successfully overcome the hybrid incompatibility. Here, we overview the research to date of sex determination and meiosis in Ellobius.

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“…Namely, the lineage studied by Srikulnath et al [2014] might have experienced a sex chromosome turnover, leading to the loss of the original lacertid sex chromosome system and appearance of a new system, based on another chromosome pair. The cases of such turnovers, when a taxon “forsakes” a well-established sex chromosome system and acquires a new one, are rather rare [Pokorná and Kratochvíl, 2016], but known in lizards [Nielsen et al, 2019] and even in mammals [Matveevsky et al, 2017]. An intraspecific polymorphism in sex-determining systems is also possible, as in the case of the frog Glandirana rugosa [Ogata et al, 2018].…”

Section: Introductionmentioning

confidence: 99%

Chromosome painting does not support a sex chromosome turnover in Lacerta agilis Linnaeus, 1758

Lisachov

Giovannotti²,

Pereira

et al. 2019

Preprint

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1Reptiles show a remarkable diversity of sex determination mechanisms and sex chromosome 2 systems, derived from different autosomal pairs. The origin of the ZW sex chromosomes of 3 Lacerta agilis, a widespread Eurasian lizard species, is a matter of discussion: is it a small 4 macrochromosome from the 11-18 group, common to all lacertids, or this species has unique ZW 5 pair derived from the large chromosome 5. Using independent molecular cytogenetic methods, 6 we investigated the karyotype of L. agilis exigua from Siberia, Russia, to identify the sex 7 chromosomes. FISH with the flow-sorted chromosome painting probe, derived from L. strigata 8 and specific to chromosomes 13, 14, and Z, confirmed that the Z chromosome of L. agilis is a 9 small macrochromosome, the same as in L. strigata. FISH with the telomeric probe showed an 10 extensive accumulation of the telomeric repeat on the W chromosome in agreement with 11 previous studies, excluding the possibility that the lineages of L. agilis studied in different works 12 could have different sex chromosome systems due to a putative intra-species polymorphism. Our 13 results reinforce the idea of the stability of the sex chromosomes and lack of evidence for sex-14 chromosome turnovers in known species of Lacertidae. 15Flo® (Beckman Coulter) high-speed cell sorter at the Cambridge Resource Centre for

show abstract

Chromosomal Evolution in Mole Voles Ellobius (Cricetidae, Rodentia): Bizarre Sex Chromosomes, Variable Autosomes and Meiosis

Cited by 27 publications

References 82 publications

Chromosome Painting Does Not Support a Sex Chromosome Turnover in Lacerta agilis Linnaeus, 1758

Chromosome Painting Does Not Support a Sex Chromosome Turnover in Lacerta agilis Linnaeus, 1758

Unusual Ways to Lose a Y Chromosome and Survive with Changed Autosomes: a Story of Mole Voles Ellobius (Mammalia, Rodentia)

Chromosome painting does not support a sex chromosome turnover in Lacerta agilis Linnaeus, 1758

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