2022
DOI: 10.3390/ijms23179852
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Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum

Abstract: Medulloblastoma is a pediatric brain malignancy that consists of four transcriptional subgroups. Structural and numerical aneuploidy are common in all subgroups, although they are particularly profound in Group 3 and Group 4 medulloblastoma and in a subtype of SHH medulloblastoma termed SHHα. This suggests that chromosomal instability (CIN), the process leading to aneuploidy, is an important player in medulloblastoma pathophysiology. However, it is not known if there is ongoing CIN in medulloblastoma or if CIN… Show more

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Cited by 2 publications
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“… 24 Nearly all GBM, medulloblastoma, and metastatic cancers are aneuploid. 24 , 25 , 26 CNS lymphoma has a notably lower rate of aneuploidy but still occurs in the majority of these cancers (71%). 24 We hypothesize that aneuploidy could act as a viable biomarker for CNS cancers, with variation in performance based on the prevalence of copy-number changes.…”
Section: Resultsmentioning
confidence: 99%
“… 24 Nearly all GBM, medulloblastoma, and metastatic cancers are aneuploid. 24 , 25 , 26 CNS lymphoma has a notably lower rate of aneuploidy but still occurs in the majority of these cancers (71%). 24 We hypothesize that aneuploidy could act as a viable biomarker for CNS cancers, with variation in performance based on the prevalence of copy-number changes.…”
Section: Resultsmentioning
confidence: 99%