“…Genomic abnormalities induced by CIN are pervasive events in cancers that correlate with advanced disease stages and higher aggressiveness by driving tumor evolution, metastases, and drug resistance. 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 38 In PCa, in which genome aberrations increase as a function of disease progression, 1 , 2 , 6 , 14 , 15 , 16 , 83 CIN and derived chromosomal errors have been associated with lethal disease, 19 , 46 , 47 but the mechanistic causes and consequences of CIN remain to be investigated. In this framework, here we uncovered that CIN is highest in castration chemotherapy-resistant metastatic PCa.…”