Chromosomal polymorphism and extra bristles of Drosophila melanogaster: joint variation under selection in isofemale lines

García‐Vázquez, Eva; Sánchez-Refusta, F.

doi:10.1007/bf00058839

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…The regions analyzed were exon, intron, 5′ UTR, 3′ UTR, upstream, downstream intergenic, and splice. There are some chromosomal inversions segregating in the populations we studied, and they are known to contribute to adaptation (Wright and Dobzhansky 1946; García‐Vázquez and Sánchez‐Refusta 1988; Kapun et al. 2014).…”

Section: Methodsmentioning

confidence: 99%

Clinal and seasonal changes are correlated in Drosophila melanogaster natural populations

2021

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Spatial and seasonal variations in the environment are ubiquitous. Environmental heterogeneity can affect natural populations and lead to covariation between environment and allele frequencies. Drosophila melanogaster is known to harbor polymorphisms that change both with latitude and seasons. Identifying the role of selection in driving these changes is not trivial, because nonadaptive processes can cause similar patterns. Given the environment changes in similar ways across seasons and along the latitudinal gradient, one promising approach may be to look for parallelism between clinal and seasonal changes. Here, we test whether there is a genome‐wide correlation between clinal and seasonal changes, and whether the pattern is consistent with selection. Allele frequency estimates were obtained from pooled samples from seven different locations along the east coast of the United States, and across seasons within Pennsylvania. We show that there is a genome‐wide correlation between clinal and seasonal variations, which cannot be explained by linked selection alone. This pattern is stronger in genomic regions with higher functional content, consistent with natural selection. We derive a way to biologically interpret these correlations and show that around 3.7% of the common, autosomal variants could be under parallel seasonal and spatial selection. Our results highlight the contribution of natural selection in driving fluctuations in allele frequencies in natural fly populations and point to a shared genomic basis to climate adaptation that happens over space and time in D. melanogaster.

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Section: Methodsmentioning

confidence: 99%

Clinal and seasonal changes are correlated in Drosophila melanogaster natural populations

2021

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“…There are some chromosomal inversions segregating in the populations we studied and they are known to contribute to adaptation (Wright and Dobzhansky 1946; García-Vázquez and Sánchez-Refusta 1988; Kapun et al 2014). We tested whether the relationship between clinal and seasonal variation is stronger inside within inversions.…”

Section: Methodsmentioning

confidence: 99%

“…The regions analyzed were exon, intron, 5’ UTR, 3’ UTR, upstream, downstream intergenic and splice. There are some chromosomal inversions segregating in the populations we studied, and they are known to contribute to adaptation (Wright and Dobzhansky 1946; García-Vázquez and Sánchez-Refusta 1988; Kapun et al 2014). We annotated SNPs surrounding (2Mb) common inversion breakpoints and added inversion status as a covariate in the linear model (Corbett-Detig and Hartl 2012).…”

Section: Methodsmentioning

confidence: 99%

Clinal and seasonal change are correlated inDrosophila melanogasternatural populations

Rodrigues

Vibranovski

Cogni

2020

Preprint

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19Spatial and seasonal variation in the environment are ubiquitous. Covariation between a trait 20 and space is often interpreted as the result of selection, but demography can complicate 21 inference. Finding seasonal changes driven by selection is challenging, given effect sizes are 22 small and the environment is subject to stochastic changes within seasons. Drosophila 23 melanogaster is known to harbor polymorphisms that change with latitude and seasons. 24Identifying the role of selection in driving latitudinal and seasonal change is not trivial, but 25 one promising approach is to look for parallel clinal and seasonal variation. Here, we test 26 whether there is a genome-wide relationship between clinal and seasonal variation, and 27 whether the pattern is consistent with selection. We investigate the role of linked selection in 28 driving these patterns, and conservatively estimate the proportion of the variants that should 29 be under selection to explain our observations. Allele frequency estimates were obtained 30 from pooled samples from seven different locations along the east coast of the US, and 13 31 samples collected in the spring and fall in Pennsylvania. We show that there is a genome-32 wide pattern of clinal variation mirroring seasonal variation, which cannot be explained by 33 linked selection alone. This pattern is stronger for coding than intergenic regions, consistent 34 with natural selection. We find that the genome-wide relationship between clinal and 35 seasonal variation could be explained by about 2.8% of the common variants being under 36 selection. Our results highlight the contribution of natural selection in driving allele 37 frequency changes with latitude and seasons in D. melanogaster. 38

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“…Many studies have reported associations between chromosomal inversions and phenotypic traits in Drosophila (e.g., Battaglia & Smith, 1961;De Jong & Bochdanovits, 2003;Dobzhansky & Pavlovsky, 1961;Dobzhansky & Spassky, 1962;Durmaz, Benson, Kapun, Schmidt, & Flatt, 2018;Etges, 1989;García-Vázquez & Sánchez-Refusta, 1988;Hoffmann & Rieseberg, 2008;Hoffmann & Weeks, 2007;Hoffmann et al, 2004;Kapun, Schmidt, Durmaz, Schmidt, & Flatt, 2016;Krimbas & Powell, 1992;Lemeunier & Aulard, 1992;Sperlich & Pfriem, 1986). However, only few studies have isolated and phenotyped a large number of chromosomal lines to examine the effects of inverted vs. noninverted chromosomes on fitness components (i.e., life history traits), the major phenotypic targets of selection (Durmaz et al, 2018;Kapun, Schmidt et al, 2016).…”

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confidence: 99%

“…Unfortunately, despite the experimental tractability of the D. melanogaster model, almost nothing is known about the phenotypic effects of other inversions in this species (Lemeunier & Aulard, 1992). One exception is the finding that the frequency of In(3R)C is correlated with bristle number and that artificial selection for increased bristle number increases the frequency of this inversion (García-Vázquez & Sánchez-Refusta, 1988;García-Vázquez, Sanchez-Refusta, & Rubio, 1989;Izquierdo, García-Vázquez, & Villar, 1991). Moreover, a series of studies showed that In(2L)t heterokaryotypes exhibit overdominance with regard to fecundity and fertility in Japanese populations (Watanabe, 1969;Watanabe & Watanabe, 1973;Watanabe, Watanabe, & Oshima, 1976).…”

mentioning

confidence: 99%

The adaptive significance of chromosomal inversion polymorphisms inDrosophila melanogaster

2018

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Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or temporally varying selection. Here, we review what has been learned about the adaptive significance of inversion polymorphisms in the vinegar fly Drosophila melanogaster, the species in which they were first discovered by Sturtevant in 1917. A large body of work provides compelling evidence that several inversions in this system are adaptive; however, the precise selective mechanisms that maintain them polymorphic in natural populations remain poorly understood. Recent advances in population genomics, modelling and functional genetics promise to greatly improve our understanding of this long-standing and fundamental problem in the near future.

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Chromosomal polymorphism and extra bristles of Drosophila melanogaster: joint variation under selection in isofemale lines

Abstract: Selection for increased numbers of dorsocentral and scutellar bristles produced an increase of In(3R)C heterozygotes in isofemale lines of D. melanogaster. The influence of polygenic selection in the maintenance of the chromosomal polymorphism is discussed.

Cited by 7 publications

References 13 publications

Clinal and seasonal changes are correlated in Drosophila melanogaster natural populations

Clinal and seasonal changes are correlated in Drosophila melanogaster natural populations

Clinal and seasonal change are correlated inDrosophila melanogasternatural populations

The adaptive significance of chromosomal inversion polymorphisms inDrosophila melanogaster

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