CHROMOSOMAL REARRANGEMENTS AND THE GENETICS OF REPRODUCTIVE BARRIERS IN<i>MIMULUS</i>(MONKEY FLOWERS)

Fishman, Lila; Stathos, Angela; Beardsley, Paul M.; Williams, Charles F.; Hill, Jeffrey P.

doi:10.1111/evo.12154

Cited by 125 publications

(199 citation statements)

References 65 publications

(129 reference statements)

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“…Second, the genomic positions of the underlying barrier loci is often unknown. Monkeyflowers are a rare exception, in which loci of large reproductive isolation effect that contribute to floral traits, flowering time and hybrid male sterility map to chromosomal rearrangements in the Mimulus genome (Ramsey et al, 2003;Lowry and Willis, 2010;Fishman et al, 2013). The putative sex-linked inversion we document in Ostrinia appears consistent with the large-effect, multicomponent prediction of chromosomal rearrangement models of speciation.…”

Section: Discussionsupporting

confidence: 74%

“…Our results add to the limited number of studies that provide empirical support for this notion, including apple maggot flies (Feder et al, 2003;Michel et al, 2010;Powell et al, 2013), fruit flies (Noor et al, 2001;Kulathinal et al, 2009), stickleback fishes (Kitano et al, 2009), sunflowers (Rieseberg, 2001;Strasburg et al, 2009) and monkeyflowers (Lowry and Willis, 2010;Fishman et al, 2013). Our finding that structural mutations contribute to speciation may be the first of many for Lepidoptera.…”

Section: Discussionsupporting

confidence: 64%

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A recombination suppressor contributes to ecological speciation in OSTRINIA moths

Wadsworth

Dopman

2015

Heredity

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Despite unparalleled access to species' genomes in our post-genomic age, we often lack adequate biological explanations for a major hallmark of the speciation process-genetic divergence. In the presence of gene flow, chromosomal rearrangements such as inversions are thought to promote divergence and facilitate speciation by suppressing recombination. Using a combination of genetic crosses, phenotyping of a trait underlying ecological isolation, and population genetic analysis of wild populations, we set out to determine whether evidence supports a role for recombination suppressors during speciation between the Z and E strains of European corn borer moth (Ostrinia nubilalis). Our results are consistent with the presence of an inversion that has contributed to accumulation of ecologically adaptive alleles and genetic differentiation across roughly 20% of the Ostrinia sex chromosome (~4 Mb). Patterns in Ostrinia suggest that chromosomal divergence may involve two separate phases-one driving its transient origin through local adaptation and one determining its stable persistence through differential introgression. As the evolutionary rate of rearrangements in lepidopteran genomes appears to be one of the fastest among eukaryotes, structural mutations may have had a disproportionate role during adaptive divergence and speciation in Ostrinia and in other moths and butterflies.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 64%

A recombination suppressor contributes to ecological speciation in OSTRINIA moths

Wadsworth

Dopman

2015

Heredity

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“…Multiplexes of three to six markers (forward primers 5 0 fluorescently labeled) were amplified using a standard touchdown PCR protocol. Additional information on the MgSTS genotyping methods can be found elsewhere (Fishman et al, , 2013.…”

Section: Materials and Methods Markersmentioning

confidence: 99%

“…Both groups of monkeyflowers have been model systems for understanding speciation for nearly five decades and were among the first wild plants investigated with linkage and quantitative trait loci mapping approaches (Bradshaw et al, 1995;Fishman et al, 2001). The two species complexes remain models for understanding both chromosomal (Fishman and Saunders, 2008;Scoville et al, 2009;Lowry and Willis, 2010;Fishman et al, 2013) and genic contributions to the maintenance of fitness variation and the development of species barriers. More recently, whole-genome sequence from M. guttatus (http: //www.Phytozome.net/) has facilitated candidate gene, fine mapping and positional cloning approaches to investigate the molecular basis of population differentiation and species divergence in Mimulus.…”

Section: Introductionmentioning

confidence: 99%

Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae)

Fishman

et al. 2014

Heredity

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Changes in chromosome number and structure are important contributors to adaptation, speciation and macroevolution. In flowering plants, polyploidy and subsequent reductions in chromosome number by fusion are major sources of chromosomal evolution, but chromosome number increase by fission has been relatively unexplored. Here, we use comparative linkage mapping with gene-based markers to reconstruct chromosomal synteny within the model flowering plant genus Mimulus (monkeyflowers). Two sections of the genus with haploid numbers X14 have been inferred to be relatively recent polyploids because they are phylogenetically nested within numerous taxa with low base numbers (n ¼ 8-10). We combined multiple data sets to build integrated genetic maps of the M. guttatus species complex (section Simiolus, n ¼ 14) and the M. lewisii group (section Erythranthe; n ¼ 8), and then aligned the two integrated maps using 4100 shared markers. We observed strong segmental synteny between M. lewisii and M. guttatus maps, with essentially 1-to-1 correspondence across each of 16 chromosomal blocks. Assuming that the M. lewisii (and widespread) base number of 8 is ancestral, reconstruction of 14 M. guttatus chromosomes requires at least eight fission events (likely shared by Simiolus and sister section Paradanthus (n ¼ 16)), plus two fusion events. This apparent burst of fission in the yellow monkeyflower lineages raises new questions about mechanisms and consequences of chromosomal fission in plants. Our comparative maps also provide insight into the origins of a chromosome exhibiting centromere-associated female meiotic drive and create a framework for transferring M. guttatus genome resources across the entire genus.

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“…2013; Fishman et al. 2013) and genetic divergence between species can increase within inverted regions through reduction of gene flow (Navarro and Barton 2003b; Jones et al. 2012; McGaugh and Noor 2012; Lohse et al.…”

Section: Introductionmentioning

confidence: 99%

No evidence for maintenance of a sympatricHeliconiusspecies barrier by chromosomal inversions

et al. 2017

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Mechanisms that suppress recombination are known to help maintain species barriers by preventing the breakup of coadapted gene combinations. The sympatric butterfly species Heliconius melpomene and Heliconius cydno are separated by many strong barriers, but the species still hybridize infrequently in the wild, and around 40% of the genome is influenced by introgression. We tested the hypothesis that genetic barriers between the species are maintained by inversions or other mechanisms that reduce between‐species recombination rate. We constructed fine‐scale recombination maps for Panamanian populations of both species and their hybrids to directly measure recombination rate within and between species, and generated long sequence reads to detect inversions. We find no evidence for a systematic reduction in recombination rates in F1 hybrids, and also no evidence for inversions longer than 50 kb that might be involved in generating or maintaining species barriers. This suggests that mechanisms leading to global or local reduction in recombination do not play a significant role in the maintenance of species barriers between H. melpomene and H. cydno.

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CHROMOSOMAL REARRANGEMENTS AND THE GENETICS OF REPRODUCTIVE BARRIERS INMIMULUS(MONKEY FLOWERS)

Cited by 125 publications

References 65 publications

A recombination suppressor contributes to ecological speciation in OSTRINIA moths

A recombination suppressor contributes to ecological speciation in OSTRINIA moths

Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae)

No evidence for maintenance of a sympatricHeliconiusspecies barrier by chromosomal inversions

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