Chromosome 10 abnormality predicts prognosis of neuroblastoma patients with bone marrow metastasis

Abstract

Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. It is known for high heterogeneity and concealed onset. In recent years, the mechanism of its occurrence and development has been gradually revealed. The purpose of this study is to summarize the clinical characteristics of children with NB and abnormal chromosome 10, and to investigate the relationship between the number and structure of chromosome 10 abnormalities and NB prognosis. Methods Chromosome G-banding was used at the time of diagnosis to evaluate the genetics of chromosomes in patients with NB and track their clinical characteristics and prognosis. All participants were diagnosed with NB in the Medical Oncology Department of the Beijing Children’s Hospital from May 2015 to December 2018 and were followed up with for at least 1 year. Results Of all 150 patients with bone marrow metastases, 42 were clearly diagnosed with chromosomal abnormalities. Thirteen patients showed abnormalities in chromosome 10, and chromosome 10 was the most commonly missing chromosome. These 13 patients had higher LDH and lower OS and EFS than children with chromosomal abnormalities who did not have an abnormality in chromosome 10. Eight patients had both MYCN amplification and 1p36 deletion. Two patients had optic nerve damage and no vision, and one patient had left supraorbital metastases 5 months after treatment. Conclusions The results indicated that chromosome 10 might be a new prognostic marker for NB. MYCN amplification and 1p36 deletion may be related to chromosome 10 abnormalities in NB. Additionally, NB patients with abnormal chromosome 10 were prone to orbital metastases.

ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase

“…A common mechanism for ASCC1 overexpression in cancer may thus be through amplification of a part, or all, of chromosome 10, given a reported linkage of chromosome 10 with cancer. Chromosome 10 is often lost in several types of brain tumors ( 27 , 28 , 29 ), neuroblastoma ( 30 ), and melanoma ( 31 ).…”

Application of the FISH method and high-density SNP arrays to assess genetic changes in neuroblastoma—research by one institute

“…The GDNF family receptor alpha 2 (GFRA2) promotes the proliferation of NB cells ( Li et al, 2019 ). According to the literature, patients with neuroblastoma and an abnormal chromosome 10 had a significantly lower 3-year OS compared to the group of patients with a normal copy number of chromosome 10 ( Jiang et al, 2021 ). In the same samples we noted an extra copy of chromosome 13, which, according to other researchers ( Bilke et al, 2008 ; Ambros et al, 2014 ) is a common chromosome in the trisomy of neuroblastoma.…”

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“…A previous clinical study has demonstrated that 50% of children with metastatic neuroblastoma had chromosome abnormalities concerning chromosome 21, 10, or 11, with abnormalities on chromosome 10 being the most frequent [ 157 ]. Jang et al [ 158 ] described the clinical characteristics of children with neuroblastoma and abnormal chromosome 10. The study showed that the overall survival rate of neuroblastoma children with abnormal chromosome 10 was significantly lower than that children with normal chromosome 10.…”