Chromosome 14q+ in adult T-cell leukemia

Miyoshi, Isao; Miyamoto, Kanji; Sumida, Mitsuo; Nishihara, R; Lai, Miinyuh; S, Yoshimoto; Sato, Jiro; Kimura, Ikuo

doi:10.1016/0165-4608(81)90092-3

Cited by 40 publications

(22 citation statements)

References 25 publications

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“…It has been convincingly associated with adult T-cell leukemia/lymphoma (ATL) (Poiesz et al, 1980;Hinuma et al, 1981;Miyoshi et al, 1981b;Yoshida et al, 1984;Takatsuki et al, 1985a, b), HAM/TSP (Cruikshank, 1956;Gessain et al, 1985;RodgersJohnson et al, 1985;Osame et al, 1986b;Rodgers, 1965), uveitis (Pinheiro, 1990(Pinheiro, , 1995Mochizuki et al, 1992) and infective dermatitis . HTLV-I has also been linked to cases of polymyositis (Inose et al, 1992;Beilke et al, 1996), synovitis (Sowa, 1992), thyroiditis (Kawai et al, 1992) and bronchioalveolar pneumonitis (Kimura, 1992), although definitive epidemiologic proof of HTLV-I association is lacking.…”

Section: Clinical Epidemiology Of Htlv-i-associated Diseasesmentioning

confidence: 99%

Global epidemiology of HTLV-I infection and associated diseases

et al. 2005

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Section: Clinical Epidemiology Of Htlv-i-associated Diseasesmentioning

confidence: 99%

Global epidemiology of HTLV-I infection and associated diseases

et al. 2005

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“…Occasional metaphases from the patient's cell line had dicentric and tricentric chromosomes, but there was no evidence of a consistent cytogenetic abnormality. DISCUSSION The incidence of ATL is relatively high among native residents of Kyushu and Shikoku in southwestern Japan and in people who were born in these areas but moved to other parts of Japan later in life (11)(12)(13). Our seroepidemiologic studies with 19 families identified a unique Japanese family with a high degree of HTLV infection (24).…”

mentioning

confidence: 99%

“…A form of adult T-cell leukemia (ATL) involving mature T lymphocytes has been described in Japan (11)(12)(13) and has been distinguished from other adult T-cell malignancies, chiefly by its tendency to cluster in Japanese originating from the islands of Kyushu and Shikoku. Recently, apparent clusters of patients with ATL have also been identified in the northwest coast of Japan (unpublished data), and leukemias and lymphomas with features similar to Japanese ATL have been observed in other geographic areas (6)(7)(8)(9)(10)14).…”

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confidence: 99%

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High incidence of human type-C retrovirus (HTLV) in family members of a HTLV-positive Japanese T-cell leukemia patient.

Sarin¹,

Aoki²,

Shibata³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

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Sera and peripheral blood cells of an adult T-cell leukemia patient and several clinically normal members of his family from the northwest coast of Japan were examined for evidence of infection with human T-cell leukemia (lymphoma) virus (HTLV). The sera of the patient and his parents had antibodies to HTLV, whereas these antibodies were absent in the sera of the patient's brother and sister. T-cell lines were established from the peripheral blood lymphocytes of all of the family members, and all except the patient's sister expressed HTLV antigens (p19, p24, and reverse transcriptase) and type-C virus particles. Not only the fresh peripheral blood lymphocytes from the patient but also those from his clinically normal mother showed abnormal morphology of the kind characteristic of some patients with T-cell leukemia. These studies are consistent with previous evidence indicative of a high rate of HTLV infection within families, and they show that people whose sera are negative for antibodies may still be infected by HTLV. In addition, the results indicate that infection of T cells by HTLV can be associated with morphological transformation of the cells without other signs of leukemia.A type-C retrovirus known as human T-cell leukemia (lymphoma) virus (HTLV) was first isolated in the United States in some cases of adult T-cell lymphoma and leukemia (1-3). This virus has been shown subsequently to be associated with T-cell leukemia patients from Japan (4, 5) and the West Indies (6, 7) by the detection of HTLV-specific antibodies in the serum of these patients. The presence of HTLV-specific antibodies in the serum and the expression of HTLV in cultured T cells have also been observed in T-cell leukemia patients originating from other regions of the United States, Israel, and Ecuador (6-10).A form of adult T-cell leukemia (ATL) involving mature T lymphocytes has been described in Japan (11-13) and has been distinguished from other adult T-cell malignancies, chiefly by its tendency to cluster in Japanese originating from the islands of Kyushu and Shikoku. Recently, apparent clusters of patients with ATL have also been identified in the northwest coast of Japan (unpublished data), and leukemias and lymphomas with features similar to Japanese ATL have been observed in other geographic areas (6)(7)(8)(9)(10)14). Recently, other investigators have also reported the isolation of a type-C retrovirus from Japanese ATL patients (15, 16). The Japanese virus isolate is a member of the HTLV group because (i) antibodies in sera of Japanese ATL patients and of some normal people in Kyushu are highly and specifically reactive with purified HTLV proteins (5) and (ii) proteins and nucleic acids of virus in the Japanese ATL cell line MT-1 are highly related or even indistinguishable from HTLV proteins and nucleic acids (17).Recently, our seroepidemiologic studies identified a unique Japanese family infected with HTLV to an extent not previously seen. One member has ATL, and another member has morphologically abnormal lymphocyt...

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“…Estudios en población indígena chilena muestran prevalencia mucho más altas, que van desde 0,74-1% en Mapuches, hasta 6,5% en Aimaras [5][6][7] . Aunque la mayoría de los infectados permanece asintomático a lo largo de su vida, el rol etiológi-co del HTLV-1 se ha establecido en la leucemia/ linfoma de células T del adulto (LLTA) [8][9][10][11][12] , la paraparesia espástica tropical (PPE) [13][14][15][16][17] , la dermatitis infectiva (DI) 18 y la uveítis 19 . Se calcula que hasta 5% de los infectados desarrolla LLTA o PPE, pero la prevalencia e incidencia varían según el área geográfica 2 .…”

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