Chromosome Aberrations and Sister-Chromatid Exchange in Workers in Chemical Laboratories and a Rotoprinting Factory and in Children of Women Laboratory Workers

Increased sister chromatid exchange frequencies in lymphocytes of nurses handling cytostatic drugs.

“…Personnel in hormone and research laboratories have been reported to have increased SCE frequencies in comparison to referents (3). In the present material, the SCE frequency of the oncology nurses and the nurses from other hospital departments did not differ statistically significantly, neither did the hospital referents show a statistically higher SCE frequency than the office personnel.…”

Chromosome aberrations and sister chromatid exchanges in Swedish paint industry workers.

“…Styrene exposure has also been found to induce chromosome aberrations (6,21), while results concerning exposure to toluene are controversial. Funes-Cravioto et al (10) reported an increase of chromosome aberrations after toluene exposure, while Forni et al (8) did not find an increase in the frequency of chromosome aberrations in humans after such exposure. With respect to sister chromatid exchanges (SCE) no increase could be found in two of these studies, in which workers exposed to toluene (10) and styrene (21) were found to exhibit excess chromosome aberrations.…”

“…Funes-Cravioto et al (10) reported an increase of chromosome aberrations after toluene exposure, while Forni et al (8) did not find an increase in the frequency of chromosome aberrations in humans after such exposure. With respect to sister chromatid exchanges (SCE) no increase could be found in two of these studies, in which workers exposed to toluene (10) and styrene (21) were found to exhibit excess chromosome aberrations. However, this finding might have been due to the ex-Reprint requests to: Ms Ulla Haglund, Department of Medical Cell Genetics, Karolinska Institute, Box 60400, S-10401 Stockholm, Sweden. tremely limited sizes of the populations examined with the SCE technique.…”

Chromosomal methods in population studies.

“…A summary of baseline values as determined in normal control subjects (> 10 individuals/study and approximately 20 cells/individual) in various laboratories (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) is illustrated in Figure 2. Possible factors contributing to the observed variation between laboratories might be due to: real differences in methods of culturing and/or scoring cells or real differences in the populations studied.…”

“…In an epidemiologic occupational study (25), SCE and chromosome aberrations were examined in lymphocytes of workers exposed to various organic solvents and of children (0-11 years) of mothers who were pregnant at the time of exposure. One group of technicians as well as the exposed children had significantly higher mean SCE/cell and chromosome aberrations relative to corresponding nonexposed controls but no correlation between SCE frequencies and aberrations was apparent.…”