Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey

Sever, Erman; Döğer, Emek; Kumbasar, Serkan; Şık, Bulat Aytek; Temür, Muzaffer; Yılmaz, Hasan; Yılmaz, Özgür; Özbay, Pelin Özün; Yücesoy, İzzet

doi:10.1016/j.tjog.2016.02.012

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Interestingly, 1q32.1 focal amplifications frequently cooccurred with 1q whole-arm amplifications. Two studies previously described (focal) 1q amplifications as a prognostic factor for endometrial cancer, albeit in a much smaller number of tumors (n ¼ 80 and n ¼ 54) without stratification for molecular subgroups (16,17). In addition, several other groups described a high frequency of (focal) 1q amplifications in endometrial cancers (6,18,19), as well as in several other malignancies such as breast cancer (20), multiple myeloma (21), and Wilms' tumors (22).…”

Section: Discussionmentioning

confidence: 99%

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Depreeuw

Stelloo

Osse

et al. 2017

Clinical Cancer Research

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Molecular classification of endometrial cancer identified distinct molecular subgroups. However, the largest subset of endometrial cancers remains poorly characterized and is referred to as the "nonspecific molecular profile" (NSMP) subgroup. Here, we aimed at refining the classification of this subgroup by profiling somatic copy-number aberrations (SCNAs). SCNAs were analyzed in 141 endometrial cancers using whole-genome SNP arrays and pooled with 361 endometrial cancers from The Cancer Genome Atlas. Genomic Identification of Significant Targets in Cancer (GISTIC) identified statistically enriched SCNAs and penalized Cox regression assessed survival effects. The prognostic significance of relevant SCNAs was validated using multiplex ligation-dependent probe amplification in 840 endometrial cancers from the PORTEC-1/2 trials. Copy-number status of genes was correlated with gene expression to identify potential cancer drivers. One plausible oncogene was validated using antisense oligonucleotide-based strategy. SCNAs affecting chromosome 1q32.1 significantly correlated with worse relapse-free survival (RFS) in the NSMP subgroup (HR, 2.12; 95% CI, 1.26-3.59; = 0.005). This effect was replicated in NSMP endometrial cancers from PORTEC-1/2 (HR, 2.34; 95% CI, 1.17-4.70; = 0.017). A new molecular classification including the 1q32.1 amplification improved risk prediction of recurrence. gene expression strongly correlated with 1q32.1 amplification. Silencing inhibited cell growth in cell lines carrying 1q32.1 amplification, but not in those without amplification., increasing expression in nonamplified cell lines stimulated cell proliferation. 1q32.1 amplification was identified as a prognostic marker for poorly characterized NSMP endometrial cancers, refining the molecular classification of this subgroup. We functionally validated as a potential oncogenic driver in the 1q32.1 region..

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Section: Discussionmentioning

confidence: 99%

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Depreeuw

Stelloo

Osse

et al. 2017

Clinical Cancer Research

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Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinoma

Wei

Yang

et al. 2016

Biomedicine & Pharmacotherapy

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Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey

Abstract: Chromosomal aberrations, particularly dup(1q), are related to advanced disease in endometrial cancer. Genetic analysis of cancer tissues may provide important insights in determining disease prognosis.

Cited by 2 publications

References 26 publications

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinoma

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