Chromosome Aberrations in Cattle with Chronic Enzootic Haematuria

Lioi, Maria Brigida; Barbieri, Rocchina; Borzacchiello, Giuseppe; Dezzi, Sandro; Roperto, Sante; Santoro, Antonietta; Russo, Valeria; Roperto, F.

doi:10.1016/j.jcpa.2004.01.011

Cited by 32 publications

(23 citation statements)

References 8 publications

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“…It promotes the full in vitro transformation of primary bovine cells infected with BPV-4 DNA [26,99] and upregulates viral DNA transcription via a cis-acting element in the viral transcriptional promoter [42]. Moreover, bracken eating cattle with BEH and/or suffering from bladder cancer develop chromosomal abnormalities [67,80,88,101,129] due to a clastogenic activity of compounds from fern. Metabolites from ptaquiloside and quercetin along with other chemicals from bracken are also found in the blood, urine and milk of cows naturally exposed to bracken and suffering from bladder cancer [15,80].…”

Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

“…Moreover, bracken eating cattle with BEH and/or suffering from bladder cancer develop chromosomal abnormalities [67,80,88,101,129] due to a clastogenic activity of compounds from fern. Metabolites from ptaquiloside and quercetin along with other chemicals from bracken are also found in the blood, urine and milk of cows naturally exposed to bracken and suffering from bladder cancer [15,80]. Exposure to ptaquiloside indirectly through milk from bracken-grazing cows has a big impact on human health, since it has been correlated with human oesophageal and gastric cancer [3,122,139].…”

Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

See 1 more Smart Citation

Bovine papillomaviruses, papillomas and cancer in cattle

Borzacchiello¹,

Roperto²

2008

Vet. Res.

173

149

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-Bovine papillomaviruses (BPV) are DNA oncogenic viruses inducing hyperplastic benign lesions of both cutaneous and mucosal epithelia in cattle. Ten (BPV 1-10) different viral genotypes have been characterised so far. BPV 1-10 are all strictly species-specific but BPV 1/2 may also infect equids inducing fibroblastic tumours. These benign lesions generally regress but may also occasionally persist, leading to a high risk of evolving into cancer, particularly in the presence of environmental carcinogenic co-factors. Among these, bracken fern is the most extensively studied. The synergism between immunosuppressants and carcinogenic principles from bracken fern and the virus has been experimentally demonstrated for both urinary bladder and alimentary canal cancer in cows whose diets were based on this plant. BPV associated tumours have veterinary and agricultural relevance in their own right, although they have also been studied as a relevant model of Human papillomavirus (HPV). Recent insights into BPV biology have paved the way to new fields of speculation on the role of these viruses in neoplastic transformation of cells other than epithelial ones. This review will briefly summarise BPV genome organization, will describe in greater detail the functions of viral oncoproteins, the interaction between the virus and co-carcinogens in tumour development; relevant aspects of immunity and vaccines will also be discussed.

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Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

Section: Bracken Fern As a Cofactor For Carcinogenesismentioning

confidence: 99%

Bovine papillomaviruses, papillomas and cancer in cattle

Borzacchiello¹,

Roperto²

2008

Vet. Res.

173

149

View full text Add to dashboard Cite

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“…Recent observations (Carvalho et al, 2006) concluded that multiple tumours (epithelial or mesenchymal or both) developed in the bladder of all cattle affected by BEH. It seems that bracken fern and bovine papillomavirus type 2 (BPV-2) act synergistically on induction of chromosomal instability (Lioi et al, 2004).…”

Section: Ruminantsmentioning

confidence: 99%

A biological hazard of our age: Bracken fern [ Pteridium aquilinum (L.) Kuhn] — A Review

Vetter

2009

Acta Veterinaria Hungarica

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Bracken fern (Pteridium aquilinum) is the fifth most distributed common weed species of the world. Its ecological distribution is very wide, and the plant can grow and spread successfully on many types of soil. The cover of P. aquilinum is -in some cases -remarkable (e.g. in the United Kingdom). Bracken fern contains different poisonous agents: some cyanogen glycosides, factors (agents) of antithiamine character (thermolabile thiaminase and thermostable other compounds) and factors of carcinogenic activity (first of all ptaquiloside). This paper summarises and reviews different toxicological problems and poisonings caused by bracken fern in ruminants (cattle, sheep) and in non-ruminant animals (horses, pigs, rats, mice, etc.). The carcinogenic properties of the norsesquiterpene-type ptaquiloside make bracken fern a potent, living hazard. Recent investigations have shown that ptaquiloside pollution of different soil layers is a distinct possibility. Ptaquiloside may leach from the soil into the drinking water base. This ecotoxicological aspect seems to be the most hazardous phenomenon in relation to P. aquilinum and ptaquiloside. The carcinogenic effect of ptaquiloside is based on its hydrolysis, which leads to the formation of a dienon intermediate. It can produce DNA adducts, which are responsible for inducing carcinoma.

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“…The bracken ferns contain toxic chemicals. The syndrome is primarily encountered in Brazil, China, Italy, Japan, Portugal, Turkey, and New Zealand [1][2][3][4][5][6][7][8][9] . Haematuria is a clinical finding of chronic enzootic haematuria appearing sporadically and attracting attention permanently.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, bracken fern comprises predominantly major toxin of ptaquiloside [18] . This toxin cause errors in DNA synthesis (especially, H-ras expression) and activation of proto-oncogenes which are controlled under cell division mechanism [4,19,20] . Because disruption of signalling cascades in the cells, this situation creates any changes in morphological diversity and biological behaviour of the cells and consequently leads to unbalanced tissue microenvironment [21,22] .…”

Section: Introductionmentioning

confidence: 99%

Türkiye’de Marmara, Orta ve Batı Karadeniz Bölgelerinde Bulunan Mandaların İdrar Keselerinde Rastlanılan Tümörlerin Patomorfolojik ve İmmunohistokimyasal Yönden İncelenmesi

Tenekeci¹,

Öztekin²,

Bozkurt³

et al. 2017

Kafkas Univ Vet Fak Derg

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In this study, non-neoplastic and neoplastic lesions in the urinary bladders of water buffalo were determined in the Marmara, the central and western part of the Black Sea region of Turkey. In this context, water buffalo with lesions in the urinary bladder were obtained from the private and public slaughterhouses of several provinces. The lesions were evaluated pathologically and immunohistochemically. In addition, species of bracken ferns were identified in these provinces. Histopathologically, 39 of the collected tissue samples were diagnosed as neoplasia. These neoplasms were classified and graded according to The World Health Organization Classification of Tumours published in 2004. In this context, papilloma (16 cases), papillary urothelial neoplasm of low malignant potential (PUNLMP) (7 cases), low-grade papillary carcinoma (13 cases), high-grade papillar carcinoma (2 cases), and low-grade papillary carcinoma with hemangiosarcoma (1 case) were detected in samples diagnosed as neoplasia. In the collected bracken ferns, Athyrium filix-foemina (L.) Roth; Dryopteris dilatata (Hoffm.) Gary; Dryopteris filixmas (L.) Schott; Polystichum aculeatum (L.) Roth; Polystichum setiferum (Forsk.) Woynar; Polystichum woronowii Fomin, Polypodium vulgare L. and Pteridium aquilinum (L.) Kuhn spp. were identified. As a result, it has been understood that the consumption of identified bracken ferns leads more frequently to epithelial neoplasms. Keywords

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Chromosome Aberrations in Cattle with Chronic Enzootic Haematuria

Cited by 32 publications

References 8 publications

Bovine papillomaviruses, papillomas and cancer in cattle

Bovine papillomaviruses, papillomas and cancer in cattle

A biological hazard of our age: Bracken fern [ Pteridium aquilinum (L.) Kuhn] — A Review

Türkiye’de Marmara, Orta ve Batı Karadeniz Bölgelerinde Bulunan Mandaların İdrar Keselerinde Rastlanılan Tümörlerin Patomorfolojik ve İmmunohistokimyasal Yönden İncelenmesi

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