Chromosome Aberrations in Two Patients with Chronic Granulocytic Leukemia Undergoing Acute Transformation

Refractory Anemia with Leukemic Transformation and Chromosomal Change

“…So far, the only specific chromosomal abnormali ty in malignant disease is the Philadelphia chromosome in chronic granulocytic leukemia [16]. The presence of this chromosome in acute myeloblastic leukemia suggests an acute transformation of a chronic granulocytic leukemia [7,12]. In other neoplastic conditions, the evolution of clones of abnormal cells has been demonstrated.…”

Cytogenetic remission in acute transformation of chronic granulocytic leukaemia.

“…Chromosome abnormalities in addition to the Philadelphia (Ph') chromosome have often been observed during acute transformation of chronic granulocytic leukaemia (Hammouds et al, 1964;Goh, 1967;Krompotic et al, 1968'. Aneuploidy with hyperdiploid cell lines, often containing more than ore Ph' chromosome, is a relatively common abnormality (Erkrmnan et al, 1967;Knospe et al, 1967).…”

“…Whether aneuploidy was also present before the onset of acute transformation is unknown; however, the disappearance of the two abnormal cell lines during remission and their subsequent return during relapse suggest that they were acquired at this stage of the disease. The development of aneuploidy in Ph'-positive cases of chronic granulocytic leukaemia is very suggestive of acute transformation and may precede overt clinical manifestations (Krompotic et al, 1968). In acute transformation the disease is unresponsive to most forms of therapy (Whang-Peng et ca., 1968), and clinical and haematological remission together with loss of aneuploidy has been observed to our knowledge in only one other case (G. P. Canellos, personal communication, 1969).…”

Cytogenetic Studies During Remission of Blastic Crisis in a Patient with Chronic Myelocytic Leukaemia

“…During blastic crisis further chromosomal aberrations may occur, including duplication of the Phl chromosome and aneuploidy of other chromosomes. Although a number of reports describe the chromosome changes occurring with blastic transformation (Kemp et a1 1962, Kiossoglou et a1 1965a, Krompotic et al 1968, Meisner et al 1970, Sandberg et al 1971 sim from the blastic crisis (Garson et al 1969).…”