Chromosome Aberrations, Sister Chromatid Exchange and Micronuclei Formation Analysis in Mice after in vivo Exposure to Bacoside A and B.

Giri, Ashok Kumar; Khan, Kainat

doi:10.1508/cytologia.61.99

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…However, since the 1960s, research has showed that some of the dyes considered safe for consumption by the ANVISA already showed signs of toxicity after human consumption [ 1 ]. An example is Tartrazine, which has carcinogenic activity and genotoxic potential, and whose toxic effects had already been reported since the 1990s by Giri et al [ 13 ] and in the 2000s by Mpountoukas et al [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Synthetic Colors in Food: A Warning for Children’s Health

de Oliveira,

Silva da Costa,

da Silva dos Santos

et al. 2024

IJERPH

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This study addressed the harmful effects of artificial colors in pediatric populations, including children diagnosed with Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), as well as those without behavioral disorders. There is a consensus that synthetic food colorings have several impacts on consumers, especially pediatrics, due to their influence on sensory appeal, which can encourage preference for certain foods. The results revealed that these color additives are directly linked to a series of health problems, with a greater impact on children, including a predisposition to pathological conditions such as carcinogenic, allergenic, mutagenic, cytotoxic, and clastogenic activities, as well as gastrointestinal and respiratory problems, in addition to behavioral changes in children with and without diagnosed disorders. The harms of synthetic dyes in children with or without comorbidities are worrying and require a careful and proactive approach from parents, caregivers and public authorities.

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Section: Resultsmentioning

confidence: 99%

Synthetic Colors in Food: A Warning for Children’s Health

de Oliveira,

Silva da Costa,

da Silva dos Santos

et al. 2024

IJERPH

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“…The leaves and stems of the plant are used to treat neurological disorders (Cauffield & Chen, 2019). A mixture of two saponins, bacoside A and its optically rotated component (isomer): bacoside B, which are the active constituents of B. monnieri has been rendered suitable for medical purposes (Cauffield & Chen, 2019; Giri & Khan, 1996). Bacoside A is a mixture of dammarene‐type triterpenoid saponins consisting of sugar chains linked to a steroid aglycone skeleton (Ramasamy et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders

Banerjee¹,

Anand

Ghosh³

et al. 2021

Phytotherapy Research

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From ancient history, complementary and alternative medicines have played a significant role as holistic therapeutic treatments of various human diseases including cancer, diabetes, neurological diseases, and skin problems. One Indian medicinal plant (herb), Bacopa monnieri has been used in many parts of the world as such medicine, particularly for the treatment of various neurological disorders. It is well known as a potent "tonic for the human brain," which serves as a memory enhancer. Multiple studies proved that this herb contains a plethora of potential bioactive, phytochemical compounds with synergistic properties. The main purpose of the present review is to shed light on the use of Bacopa monnieri and its active principles (bacosides) in the management of neurological disorders. Furthermore, the signaling pathways modulated by bacosides have been critically discussed in this review. Moreover, we have critically summarized the present knowledge of this perennial creeping herb based upon the literature mining from different scientific engines.

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