Chromosome Analysis, Nuclear Sex, Clinical and Endocrine Studies of a True Hermaphrodite

True hermaphroditism or gonadal intersexuality. Cytogenetic and gonadal analyses of 5 new examples related to 67 known cases studied cytogenetically.

“…In those subjected to full cytogenetic analysis there were four individuals, all with 46/XX chromosome pattern, in whom the configuration of the external genitalia was entirely normal male (Bregman et al, 1963;Roberts and Khajavi, 1964;Rosenberg, Clayton, and Hsu, 1963, Case 2) or normal female (O'Mahony, 1966). In all other patients some external genital abnormality was present.…”

Influence of the Y chromosome on gonadal differentiation: asymmetrical gonads in an XO-XY mosaic.

“…Testicular Differentiation in Absence of a Y Chromosome. Several instances of true hermaphroditism, well studied by multiple biopsies (Bregman, Bregman, Cushner, and Woods, 1963;Hungerford et al, 1964;Root, Eberlein, Briebart, Moorhead, and Mellman, 1964), have been reported to have a uniform female XX type of chromosome complement. In addition, at least one man (with bilateral atrophic testes), studied by De la Chapelle et al (1964), had an XX constitution in all tissues cultured, including testes.…”