A system for machine assisted karyotyping and chromosome analysis has been developed. The system uses a drum-or TV-scanner as input device, runs provisionally in 32 K memory, and also allows human interaction on several stages. The accuracy with which banded chromosomes are karyotyped I Supported by F. G. W. 0. Grant 20. 492. 2 Aspirant National Foundation of Scientific Research. 3 Bursaal I. W. 0. N. L.