Chromosome ends and the theory of marginotomy: implications for reproduction

Córdova-Oriz, Isabel; Polonio, Alba M.; Cuadrado-Torroglosa, Isabel; Chico-Sordo, Lucía; Medrano, Marta; García-Velasco, Juan A.; Varela, Elisa

doi:10.1007/s10522-023-10071-w

Biogerontology

2023

DOI: 10.1007/s10522-023-10071-w

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Chromosome ends and the theory of marginotomy: implications for reproduction

Isabel Córdova-Oriz,

Alba M. Polonio,

Isabel Cuadrado-Torroglosa

et al.

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2024

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Cited by 4 publications

References 180 publications

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Telomeres in health and longevity: special issue in memory of Alexey Olovnikov

Olovnikov

2024

Biogerontology

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Telomeres in health and longevity: special issue in memory of Alexey Olovnikov

Olovnikov

2024

Biogerontology

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An in-silico approach to the dynamics of proliferation potential in stem cells and the study of different therapies in cases of ovarian dysfunction

Portillo,

García-Velasco,

Varela

2024

Mathematical Biosciences

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Telomeric function and regulation during male meiosis in mice and humans

Yin,

Jiang,

et al. 2024

Andrology

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BackgroundTelomeres are unique structures situated at the ends of chromosomes. Preserving the structure and function of telomeres is essential for maintaining genomic stability and promoting genetic diversity during male meiosis in mammals.Material‐MethodsThis review compiled recent literature on the function and regulation of telomeres during male meiosis in both mice and humans, and also highlighted the critical roles of telomeres in reproductive biology and medicine.Results‐DiscussionVarious structures, consisting of the LINC complex (SUN‐KASH), SPDYA‐CDK2, TTM trimer (TERB1‐TERB2‐MAJIN), and shelterin, are critical in controlling telomeric activities, such as nuclear envelope attachment and bouquet formation. Other than telomere‐related proteins, cohesins and genes responsible for regulating telomere function are also highlighted, though the exact mechanism remains unclear. The gene‐mutant mouse models with meiotic defects directly reveal the essential roles of telomeres in male meiosis. Recently reported mutant genes associated with telomere activity in clinical practice have also been illustrated in detail.ConclusionsProper regulation of telomere activities is essential for male meiosis progression in mice and humans.

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Chromosome ends and the theory of marginotomy: implications for reproduction

Cited by 4 publications

References 180 publications

Telomeres in health and longevity: special issue in memory of Alexey Olovnikov

Telomeres in health and longevity: special issue in memory of Alexey Olovnikov

An in-silico approach to the dynamics of proliferation potential in stem cells and the study of different therapies in cases of ovarian dysfunction

Telomeric function and regulation during male meiosis in mice and humans

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