1989
DOI: 10.1016/0921-8734(89)90013-1
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Chromosome instability in lymphocytes from a patient with Werner's syndrome is not associated with DNA repair defects

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Cited by 47 publications
(29 citation statements)
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“…TRF2-bound substrate did not hinder the progression of the helicase complex (84 Ϯ 5% displacement; see lane 7). In summary, both WRN and BLM partnered with RPA retain helicase activity on substrates bound by TRF2.…”
Section: Association Of Trf2 With Wrn and Blm Stimulates Theirmentioning
confidence: 95%
“…TRF2-bound substrate did not hinder the progression of the helicase complex (84 Ϯ 5% displacement; see lane 7). In summary, both WRN and BLM partnered with RPA retain helicase activity on substrates bound by TRF2.…”
Section: Association Of Trf2 With Wrn and Blm Stimulates Theirmentioning
confidence: 95%
“…Thus, it is likely that some of these pathways, although sharing a subset of common components, may also utilize a number of unique and more specialized factors. WRNϪ/Ϫ fibroblasts are sensitive to 4-nitroquinoline 1-oxide but are insensitive to other DNA-damaging agents such as ionizing radiation (44,45), suggesting that if WRN is directly involved in the processing of damaged DNA, it may be required for the repair of a specific subset of DNA lesions. A later study on the ligation of linear plasmid DNA in lymphoblast cells from WS patients showed an increased rate of deletion at the ligation site but no reduction in end joining (46).…”
Section: Discussionmentioning
confidence: 99%
“…WS cells also show hypersensitivity to selected DNA-damaging agents including 4-nitroquinoline-1-oxide (4NQO; 6), topoisomerase inhibitors (7), and certain DNA cross-linking agents (8). Compared with normal cells, WS cells also exhibit increased genomic instability including higher levels of DNA deletions, translocations, and chromosomal breaks (9,10), suggesting that WRN plays an important role in one or more genome maintenance pathways (11).…”
mentioning
confidence: 99%