Chromosome Investigation in Married Couples With Repeated Spontaneous Abortions

Chromosome variants and abnormalities detected in 51 married couples with repeated spontaneous abortions

“…Our results correlate with those of Kadotani et al (1969), Kulazhenko et al (1972), Kaosaar & Mikelsaar (1973), Patil &Lubs (1977 andNielsen (1978), who reported a higher frequency of spontaneous abortions in married couples where the husband was proved to demonstrate a large Y chromosome. In our study, 19.6 % of males had a Yq+, whereas the frequency of large Y chromosomes in the normal adult male population does not exceed 1.…”

Chromosome Variants and Abnormalities Detected in 51 Married Couples with Repeated Spontaneous Abortions

“…Our results correlate with those of Kadotani et al (1969), Kulazhenko et al (1972), Kaosaar & Mikelsaar (1973), Patil & Lubs (1977and Nielsen (1978, who reported a higher frequency of spontaneous abortions in married couples where the husband was proved to demonstrate a large Y chromosome. In our study, 19.6 % of males had a Yq+, whereas the frequency of large Y chromosomes in the normal adult male population does not exceed 1.…”

Chromosome analyses in couples with repeated pregnancy loss

“…The heteromorphisms were identified using the criteria shown in Table 1. These criteria are an amalgamation of those suggested by other authors (Lubs & Ruddle, 1970;Hamerton et al, 1972;Kaosaar & Mikelsaar, 1973;Nielsen & Sillesen, 1975). A heteromorphism was only scored as present if it was visible in at least 50% of the cells analysed.…”

“…Schmid, 1962Rowley et al, 1963Wingate, 1965Singh etal., 1966McKay et al, 1967Makino, 1967Shaw, 1967Stenchever et al, 1968Wilson, 1969Kulazhenko et al, 1972Lucas et al, 1972Rott etal, 1972Waiter & Foussereau, 1972Bhasinefa/., 1973Kaosaar & Mikelsaar, 1973Khudr, 1974Papp etal, 1974Rani et al, 197'4 Broustet et al, 1975Korner, 1975Pernod ef al, 1975Tsenghi et al, 1976Schmidt et al, 1976Breuker et al, 1977Stenchever et al, 1977Adzicera/., 1978Heritage et al, 1978Kajii & Ferrier, 1978Lancet etal, 1978Duca etal, 1979Genest, 1979Hemming & Burns, 1979Luthyefa/., 1979 Neue/a/., 1979 Pesciae/a/., 1979 Tho etal, 1979t Bortotto et al, 1980Biihler, 1980V&edetal, 1980Schmid, 1980Subrt, 1980Ward et al, 1980 Though the suggestion ( Table 6) that the frequency of chromosome anomalies may be higher in couples of groups 2 and 3 with a mixed poor obstetric history (12-5%) than in couples experiencing only abortions (5-2%) was not significant, a similar trend was reported by Tho, Byrd & McDonough (1979), respectively 23% Table 12. Incidence of chromsome anomalies in couples with a history of two or more spontaneous abortions Autho...…”

“…1962Rowley el al., 1963Wingate. 1965Bishun & Morton, 1968Pergament el al., 1968Kadotani el al., 1969Wilson, 1969Golob & Kunze-Muhl, 1971Kulazhenkoefa/., 1972Rott el al., 1972Chapelle & Schroder, 1973Kaosaar & Mikelsaar, 1973Khudr, 1974Korner, 1975Tsenghi el al., 1976Gilgenkrantz«a/., 1976Rosenmann el al., 1977Lancet el al., 1978Genest, 1979Pescia«a/., 1979Tsvetcova & Yankova, 1979Wardrta/., 1980Present study, 1981 used for the identification of heteromorphisms are very similar to the present series, but again it seems that the numbers studied are too few. The suggestion from the pooled data that Yq+ heteromorphisms are more frequent in abortion parents than in the general population is supported by the studies of Patil & Lubs (1977) and Nielsen (1978), in which the maternal obstetric histories of all newborns with and without a Yq+ chromosome were compared; in both studies there was a statistically increased incidence of abortion in the couples with a son with a Yq+ chromosome.…”