2024
DOI: 10.21203/rs.3.rs-4254475/v1
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Chromosome segregation of human non-homologous Robertsonian translocations: insights from preimplantation genetic testing

Peter Benn,
Katrina Merrion

Abstract: Robertsonian translocations (RTs) are associated with a high risk for unbalanced segregations. Preimplantation Genetic Testing (PGT) offers an early opportunity to evaluate segregation patterns and selection against chromosome imbalances. The objective of this study was to evaluate the chromosome complements in blastocysts for male and female RT carriers and provide information useful in PGT counseling for RT carriers. PGT results were reviewed for 296 couples where a balanced and non-homologous RT was present… Show more

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