Chromosome Translocation in Peripheral Neuroepithelioma

Whang‐Peng, Jacqueline; Triche, Timothy J.; Knutsen, Turid; Miser, James S.; Douglass, Edwin C.; Israel, Mark A.

doi:10.1056/nejm198408303110907

Cited by 361 publications

(112 citation statements)

References 8 publications

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“…The translocation t(11;12)(q24;q12) is a karyotypic abnormality detected in ‫ف‬ 90% of both ES and PNET (9)(10)(11). As a result of this translocation, two genes, the EWS gene on chromosome 22 and the Fli1 gene on chromosome 11, are fused in ES and PNET cells (3).…”

Section: Introductionmentioning

confidence: 99%

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

Tanaka¹,

Iwakuma²,

Harimaya³

et al. 1997

J. Clin. Invest.

253

192

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Section: Introductionmentioning

confidence: 99%

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

Tanaka¹,

Iwakuma²,

Harimaya³

et al. 1997

J. Clin. Invest.

253

192

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“…The chromosomal translocation t(11, 22)(q24; q12) is found in Ͼ90% of peripheral PNET-ES and appears to be characteristic (7,23,24). It results in the fusion of the EWS gene with a truncated transcription factor FLI1 on 11q24, causing oncogenic conversion of the EWS gene.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors typically express high amounts of the MIC2 antigen (CD99) (6) and exhibit highly characteristic chromosomal translocation that results in the fusion of the EWS gene with any of several members of the ETS family of transcription factors, leading to oncogenic activation of the EWS gene (7).…”

mentioning

confidence: 99%

Primary Peripheral PNET/Ewing's Sarcoma of the Dura: a Clinicopathologic Entity Distinct from Central PNET

et al. 2002

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We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

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“…Peripheral PNETprobably includes the tumors described as malignant tumors of the thoracopulmonaryregion in childhoodand adolescence as a uniqueclinicopathologic entity (Askin tumor) (7)(8)(9). Peripheral PNETis uncommonand may occur at any age, though most cases occur in the second and third decades of life ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

Peripheral Primitive Neuroectodermal Tumor Involving the Paravertebral and Retroperitoneal Regions.

et al. 1997

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A rare case of peripheral primitive neuroectodermal tumor (PNET) is reported. A 68-year-old womancomplaining of lumbago was admitted to our hospital. Diagnosis was made based on pathological findings characterized by Homer Wright-type rosettes. Ultrastructural examination showed the presence of neurosecretory granules and short cytoplasmic processes, which were highly suggestive of neural differentiation. Chromosomalanalysis of the neoplastic cells revealed translocation (H;22)(q24;ql2), which is often found in Ewing's sarcoma and Askin tumor. These results strengthen the hypothesis of a commonhistogenesis for these small round cell tumors, and suggest common oncogenesis for these neoplasms. (Internal Medicine 36: 424-429, 1997)

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Chromosome Translocation in Peripheral Neuroepithelioma

Cited by 361 publications

References 8 publications

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

Primary Peripheral PNET/Ewing's Sarcoma of the Dura: a Clinicopathologic Entity Distinct from Central PNET

Peripheral Primitive Neuroectodermal Tumor Involving the Paravertebral and Retroperitoneal Regions.

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