Chromosomes in Anorexia Nervosa. A Study of 47 Cases Including a Population‐Based Group: A Research Note

Råstam, Maria; Gillberg, Christopher; Wahlström, Jan

doi:10.1111/j.1469-7610.1991.tb00344.x

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…By 1977 Kron and colleagues had reported the ninth subject in which AN and Turner syndrome (XO gonodal dysgenesis) coincided. However, in a study of 47 typical AN patients, Rastam et al (1991) were unable to ®nd any clear evidence of association between Turner's syndrome and AN.…”

Section: Evidence Of a Genetic Component In Anorexia Nervosamentioning

confidence: 86%

Understanding the genetic predisposition to anorexia nervosa

Pieri

Campbell

1999

Eur. Eat. Disorders Rev.

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The aim of this article is to review the current evidence for a genetic component of susceptibility to anorexia nervosa. We discuss the historical data that gave rise to the theory of a genetic component underlying susceptibility to anorexia nervosa and discuss the relative importance of the assumptions made. We illustrate through reference to more recent studies the type of approach that will be required to determine the genes involved in this underlying genetic susceptibility and summarise the story so far. There is now supporting data consistent with the theory that a genetic component is involved in the susceptibility to anorexia nervosa. However, it is clear that further studies involving larger numbers of subjects are required in order to clarify these recent ®ndings. The current case±control association studies may go some way towards describing the genetic component of anorexia nervosa. However, it is important to accept that replication in independent study cohorts will be required before the rest of the scienti®c world will accept the current evidence. A world-wide study is currently under way. It allows patient cohorts from different countries to be compared. We hope that it will enable us to understand more clearly the genetics of this complex disorder.

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Section: Evidence Of a Genetic Component In Anorexia Nervosamentioning

confidence: 86%

Understanding the genetic predisposition to anorexia nervosa

Pieri

Campbell

1999

Eur. Eat. Disorders Rev.

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Background factors in anorexia nervosa

Råstam¹,

Gillberg²

1992

European Child & Adolescent Psychiatry

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Fifty-one adolescents with anorexia nervosa and 51 sex-, age- and school-matched comparison cases were psychiatrically and physically examined. Twenty-four of the anorexia cases constituted the total population of anorexia nervosa cases born in 1970. The cases were examined at a mean age of 16 years. The mothers were interviewed in detail concerning hereditary and other family factors, child's early physical and temperamental development, and the family's overall social situation. Medical records pertaining to the pre-, peri- and neonatal periods were analysed blind to diagnosis. Thirty-five of the anorexia cases (69%) had a reasonably plausible background factor which could have contributed to the development of the eating disorder. Similar background factors were encountered in 2 (4%) of the comparison cases. The findings are discussed as they pertain to anorexia nervosa etiology.

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Anorexia nervosa: Recent research findings and implications for clinical practice

Råstam

1994

European Child & Adolescent Psychiatry

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Chromosomes in Anorexia Nervosa. A Study of 47 Cases Including a Population‐Based Group: A Research Note

Cited by 5 publications

References 28 publications

Understanding the genetic predisposition to anorexia nervosa

Understanding the genetic predisposition to anorexia nervosa

Background factors in anorexia nervosa

Anorexia nervosa: Recent research findings and implications for clinical practice

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