Chromosomes in the genesis and progression of ependymomas

Genetic abnormalities in oligodendroglial and ependymal tumours

“…Deletion or rearrangement at the short arm of chromosome 1 has been reported in adult ependymomas [41]. Loss of the X chromosome has also been demonstrated [32,38].…”

“…Chromosome arm 22 q has been the most frequently described region of genomic loss in ependymomas [9,38,47]. Cytogenetic deletions and/or LOH on chromosome 22 are consistent findings in several CNS tumours, such as human gliomas of different histopathological grades, acoustic neuromas, and meningiomas.…”

“…Similar abnormalities are found in several extracranial tumours, including rectal carcinomas, mesotheliomas, and peripheral benign schwannomas. The loss of chromosome 22 occurs in a larger proportion of ependymomas in adults than in children [21,38,49]. Abnormalities of chromosome 22, mainly monosomy, occur in 30 % of ependymomas; deletions or translocations involving 22 q have also been found [28,51].…”

“…Monosomy 10 and deletions 10 q or 10 p are rare genetic alterations [1,5,13,31,38]. Deletions of 9 p, 11, 13, and 17 in ependymomas have been reported occasionally [1,13,18,31,32,41].…”

“…Moreover, the more favourable clinical course of spinal ependymomas may relate to a distinct pattern of genetic alterations different from that of intracerebral ependymomas [9]. Other abnormalities in ependymomas involve monosomy or deletion of chromosome 6 [1,32,38]. In a recent study analysing samples of primary paediatric ependymomas for significant gains or losses of genomic DNA using comparative genomic hybridization, chromosome arm 6 q was frequently deleted [32].…”