2023
DOI: 10.1101/2023.05.25.542365
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Chronic activation of tubulin tyrosination in HCM mice and in human iPSC-engineered heart tissues improves heart function

Niels Pietsch,
Christina Y. Chen,
Svenja Kupsch
et al.

Abstract: Rationale: Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder caused by sarcomeric gene variants and associated with left ventricular (LV) hypertrophy and diastolic dysfunction. The role of the microtubule network has recently gained interest with the findings that α-tubulin detyrosination (dTyr-tub) is markedly elevated in heart failure. Reduction of dTyr-tub by inhibition of the detyrosinase (VASH/SVBP complex) or activation of the tyrosinase (tubulin tyrosine ligase, TTL) markedly… Show more

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