Chronic Active Hepatitis: The Spectrum of Disease

Hodges, John R.; Millward-Sadler, G. H.; Wright, Ralph

doi:10.1016/s0140-6736(82)92056-6

Cited by 72 publications

(41 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…'-5 Although the crucial studies at the start ofthe last decade defined the condition and established appropriate treatment regimes, certain aspects of the condition, as seen in a non-referral centre, have not been emphasized despite increasing knowledge of the pathogenesis of CAH. [5][6][7][8] The present study establishes the incidence of the condition in a defined population, assesses changes in the pattern of inci' -nce, measures long-term prognosis and tre, lient outcome, and categorizes the aetioloey in ilis non-referral population. Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Chronic active hepatitis: a sixteen year survey at a district general hospital

Tanner

Dellipiani

1989

Postgraduate Medical Journal

View full text Add to dashboard Cite

Summary: Over a period of 16 years There were 7 deaths, three unrelated to liver disease. Survival analysis gives an 86% 5-year survival and 56% 10-year survival. Twenty four patients were treated with steroids (and 6 additionally with azathioprine); 15 (63%) were steroid responsive and 9 were non-responsive. In five patients steroids were successfully discontinued but in 10 patients severe symptomatic relapse occurred on steroid reduction below 7.5-10 mg/day. Steroid non-responders were not typical CAH, 5 with predominantly a rise in alkaline phosphatase, one multisystem disease and one HBV positive. Steroid discontinuation was only possible in one third of the patients responding. Eighteen subjects (69%) were cirrhotic at initial biopsy; 9 had follow-up biopsies, 6 were unchanged but three had progressed to cirrhosis despite apparent steroid responsiveness.

show abstract

Section: Introductionmentioning

confidence: 99%

Chronic active hepatitis: a sixteen year survey at a district general hospital

Tanner

Dellipiani

1989

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…Minor abnormalities of liver function are frequent in rheumatoid arthritis but the prevalence and cause of chronic liver disease in this condition are unknown. One case of rheumatoid arthritis was noted among 61 cases of Al-AT associated liver disease (Hodges et al, 1982). In these cases, serum Al-AT was inappropriately low, characteristic globules were found in the liver and both were MZ phenotype.…”

Section: Discussionmentioning

confidence: 99%

Alpha-1-antitrypsin associated liver disease in rheumatoid arthritis

Teh

Steven

Capell

1985

Postgraduate Medical Journal

View full text Add to dashboard Cite

Summary Two cases of alpha-1-antitrypsin associated liver disease occurring in patients with rheumatoid arthritis are described. Both presented with abnormal liver function tests and the true diagnosis was only apparent after liver biopsy and detailed serological studies. The concurrence of these two conditions is noteworthy because of the postulated role of proteolytic enzymes in producing the characteristic cartilaginous erosions of rheumatoid arthritis.

show abstract

“…[9][10][11] In the few population-based studies that have tried to define the etiology of CLD or cirrhosis, excess alcohol consumption was demonstrated to contribute to approximately 50% of cases. 12 However, such studies have not determined the relative contribution of HBV, HCV, or HGV infection to CLD in the United States. Furthermore, such studies have not evaluated areas such as central Harlem that experience a disproportionate burden of CLD morbidity and mortality.…”

Section: Formentioning

confidence: 99%

Chronic Liver Disease in Central Harlem: the Role of Alcohol and Viral Hepatitis

et al. 1999

View full text Add to dashboard Cite

Forreasons not yet determined, chronic liver disease (CLD) has been a leading cause of excess morbidity and mortality in central Harlem. We conducted a case series and case-control analysis of demographic, clinical, epidemiological, and alcohol-intake-related information from patients with CLD and age-and sex-matched hospitalized control patients. Patients' sera were tested for markers of viral hepatitis. The presumed etiology of CLD among casepatients was as follows: both alcohol abuse and hepatitis C virus (HCV) infection, 24 persons (46% of case-patients); alcohol abuse alone, 15 (29%); HCV infection alone, 6 (12%); both alcohol abuse and chronic hepatitis B virus (HBV) infection, 3 (6%); and 1 each (2%) from: 1) schistosomiasis, 2) sarcoidosis, 3) unknown causes, and 4) alcohol abuse, chronic HBV, and HCV combined. In the case-control analysis, patients who had both alcoholism and either HBV (odds ratio Chronic liver disease (CLD) is an important cause of morbidity and mortality in the United States, 1,2 and although deaths from CLD have declined recently, the reason for this decrease has not been determined. 3,4 In central Harlem, the mortality rate for CLD is five times the national average, nearly twice the rate of the next-highest New York City community, 5 and in central Harlem during 1979 through 1981, it was the second leading cause of excess deaths. 6 Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) is associated with the development of CLD. 7,8 In addition, persons who have hepatitis that is not caused by known viral etiologies of hepatitis (non-ABCDE hepatitis) are at risk for CLD, suggesting that the recently characterized hepatitis G virus (HGV) may cause CLD. [9][10][11] In the few population-based studies that have tried to define the etiology of CLD or cirrhosis, excess alcohol consumption was demonstrated to contribute to approximately 50% of cases. 12 However, such studies have not determined the relative contribution of HBV, HCV, or HGV infection to CLD in the United States. Furthermore, such studies have not evaluated areas such as central Harlem that experience a disproportionate burden of CLD morbidity and mortality.[In the United States, the estimated prevalence of chronic HBV infection is 0.3%, 13 and 1.8% of the population is infected with HCV. 14 For both HBV and HCV, the rate of infection is significantly higher in African-Americans and Hispanics than in whites. 13,15 To determine the relative contribution of consumption of alcohol and the various types of viral hepatitis to the elevated rates of CLD observed in central Harlem, we conducted a prospective, hospital-based, case-control study. PATIENTS AND METHODSStudy Population. The study was conducted at Harlem Hospital Medical Center, which serves more than 60% of the CLD patients from central Harlem (New York State Department of Health, unpublished data, August, 1990). Case-patients were identified from August 1, 1991, through June 30, 1992, by review of: 1) the hospital' s admission and discharge rosters;...

show abstract

Chronic Active Hepatitis: The Spectrum of Disease

Cited by 72 publications

References 13 publications

Chronic active hepatitis: a sixteen year survey at a district general hospital

Chronic active hepatitis: a sixteen year survey at a district general hospital

Alpha-1-antitrypsin associated liver disease in rheumatoid arthritis

Chronic Liver Disease in Central Harlem: the Role of Alcohol and Viral Hepatitis

Contact Info

Product

Resources

About