1994
DOI: 10.1161/01.hyp.24.5.571
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Chronic administration of aldosterone depresses baroreceptor reflex function in the dog.

Abstract: In a previous study it was shown that acute perfusion of aldosterone into the isolated carotid sinus decreased baroreceptor activity. The aim of the present study was to determine whether chronic, systemic administration of aldosterone also depresses baroreflex function. In six conscious dogs, the baroreflex was determined before and 10 days after an osmotic minipump containing aldosterone (100 ixg/kg in 2 mL) was implanted. The slope of the relation between systolic arterial pressure and heart rate was signif… Show more

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Cited by 142 publications
(79 citation statements)
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“…Aldosterone also causes direct vascular damage and baroreceptor dysfunction and prevents the uptake of norepinephrine by the myocardium. 3,[33][34][35] The present study shows that aldosterone production is activated in the ventricles of patients with hypertension. Myocardial levels of aldosterone are reported to be many times higher than those in plasma, 8 suggesting that not only does cardiac tissue possess the capacity to synthesize its own aldosterone, but its retention within the heart is important for localized functions.…”
Section: Discussionsupporting
confidence: 55%
“…Aldosterone also causes direct vascular damage and baroreceptor dysfunction and prevents the uptake of norepinephrine by the myocardium. 3,[33][34][35] The present study shows that aldosterone production is activated in the ventricles of patients with hypertension. Myocardial levels of aldosterone are reported to be many times higher than those in plasma, 8 suggesting that not only does cardiac tissue possess the capacity to synthesize its own aldosterone, but its retention within the heart is important for localized functions.…”
Section: Discussionsupporting
confidence: 55%
“…Aldosterone also causes direct vascular damage and baroreceptor dysfunction and prevents uptake of norepinephrine by the myocardium. 4,29,30 Recently, Pitt and coworkers 31 showed that blocking aldosterone with a low dose of spironolactone substantially reduced the risks of morbidity and mortality among patients with severe heart failure (RALES trial). Efficacy of an aldosterone blockade in their trial does not appear to be due entirely to prevention of sodium retention or potassium loss.…”
Section: Discussionmentioning
confidence: 99%
“…Experimental data suggest that aldosterone influences the autonomic nervous system in animal models 34 and in man. 35 In particular, aldosterone antagonists increased myocardial norepinephrine uptake 36 and improved heart rate variability in patients with congestive heart failure.…”
Section: Discussionmentioning
confidence: 99%