Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats

Odigie, I.P.; Ettarh, RR; Adigun, S. A.

doi:10.1016/s0378-8741(03)00078-3

Cited by 157 publications

(103 citation statements)

References 17 publications

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“…HS is composed of alkaloids, L-ascorbic acid, anisaldehyde, anthocyanin, β-carotene, β-sitosterol, citric acid, cyanidin-3-rutinoside, delphinidin, galactose, gossypetin, hibiscetin, mucopolysaccharide, pectin, protocatechuic acid, polysaccharide, quercetin, and stearic acid. 9 Currently, the dried calyx extracts of HS are commercially available in the form of granules or tea and sold as health food products that are diuretic, hypocholesterolemic, 8 antihypertensive, 10,11 and an antioxidant. 9 Most importantly, HS was recently demonstrated to be effective in attenuating the progression of kidney injury in streptozocin-induced diabetic nephropathy in rats through its antilipidemic and antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

“…For example, HS has been shown to have antibacterial, hypocholesterolemic, 8 antioxidant, 9 and vasodilatory activities. 10,11 In addition, HS was able to lower high blood pressure in hypertensive rats 11 and patients. 5 Several activities such as nitric oxide inhibitor, 12 calcium channel blocker, 13 and angiotensin-converting enzyme inhibitor 14 were known to explain the hypotensive effects of HS.…”

Section: Introductionmentioning

confidence: 97%

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Hibiscus SabdariffaLinnaeus Aqueous Extracts Attenuate the Progression of Renal Injury in 5/6 Nephrectomy Rats

et al. 2012

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Hibiscus sabdariffa Linn. (HS) is a tropical wild plant with antioxidant, antibacterial, antihypertensive, and lipid-lowering properties. In several animal models, HS aqueous extracts reduced the severity of the multi-organ injuries such as hypertension and diabetic nephropathy. One of the multiorgan injuries is chronic kidney disease (CKD), which results from the loss of nephron function. HS was used in a 5/6 nephrectomy (5/6 Nx) rat model to determine if it could attenuate the progression of CKD. HS (250 mg/kg/day) or placebo was orally administered to 5/6 Nx male Sprague-Dawley rats. The NxþHS group had fewer renal injuries as measured by blood urea nitrogen, serum creatinine, creatinine clearance, and renal pathology when compared with the Nx group. In order to determine which property of HS, either vasodilatory and/or antioxidant, was important in attenuating the progression of CKD, systolic blood pressure (SBP) and serum levels of malondialdehyde (MDA) were assessed. In the NxþHS group, the SBP and the serum levels of MDA were significantly lower at Week 7. In conclusion, through either antihypertensive and/or antioxidant properties, HS was able to attenuate the progression of renal injury after 5/6 Nx. Hence, HS should be considered as one of the new, promising drugs that can be used to attenuate the progression of CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Hibiscus SabdariffaLinnaeus Aqueous Extracts Attenuate the Progression of Renal Injury in 5/6 Nephrectomy Rats

et al. 2012

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“…Its flowers contain polyphenolic acid, flavonoids and anthocyanins (Chen et al 2003) with a considerable antioxidant activity (Tseng et al 1997;Wang et al 2000;Odigie et al 2003). There are numerous studies regarding HS components (Samy 1980;Rao 1996;Tsai et al 2002;Blazovics et al 2003) and their health-promoting properties.…”

Section: Hibiscus Sabdariffa L Extractmentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.ARTICLE HISTORY

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“…In view of its reported nutritional and pharmacological properties and relative safety, H. sabdariffa and compounds isolated from it could be a source of therapeutically useful products. 9,10 Different studies, both in animal [11][12][13][14] and human models, 15,16 have shown that an extract or infusion of ST influences the atherosclerosis process, blood sugar and lipids, and BP. Lin et al 17 reported that ST infusion reduces cholesterol by 8.3-14.4% after 4 weeks.…”

Section: Introductionmentioning

confidence: 99%

The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes

et al. 2008

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To compare the antihypertensive effectiveness of sour tea (ST; Hibiscus sabdariffa) with black tea (BT) infusion in diabetic patients, this double-blind randomized controlled trial was carried out. Sixty diabetic patients with mild hypertension, without taking antihypertensive or antihyperlipidaemic medicines, were recruited in the study. The patients were randomly allocated to the ST and BT groups and instructed to drink ST and BT infusions two times a day for 1 month. Their blood pressure (BP) was measured on days 0, 15 and 30 of the study. The mean of systolic BP (SBP) in the ST group decreased from 134.4 ± 11.8 mm Hg at the beginning of the study to 112.7 ± 5.7 mm Hg after 1 month (P-value o0.001), whereas this measure changed from 118.6 ± 14.9 to 127.3 ± 8.7 mm Hg (P-value ¼ 0.002) in the BT group during the same period. The intervention had no statistically significant effect on the mean of diastolic BP (DBP) in either the ST or BT group. The mean pulse pressure (PP) of the patients in the ST group decreased from 52.2±12.2 to 34.5±9.3 mm Hg (P-value o0.001) during the study, whereas in the BT group, it increased from 41.9 ± 11.7 to 47.3 ± 9.6 mm Hg (P-value ¼ 0.01). In conclusion, consuming ST infusion had positive effects on BP in type II diabetic patients with mild hypertension. This study supports the results of similar studies in which antihypertensive effects have been shown for ST.

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Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1C hypertensive rats

Cited by 157 publications

References 17 publications

Hibiscus SabdariffaLinnaeus Aqueous Extracts Attenuate the Progression of Renal Injury in 5/6 Nephrectomy Rats

Hibiscus SabdariffaLinnaeus Aqueous Extracts Attenuate the Progression of Renal Injury in 5/6 Nephrectomy Rats

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes

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