Chronic administration of NaHS and L-Cysteine restores cardiovascular changes induced by high-fat diet in rats

C, Gómez; Cruz, Saúl Huerta de la; Medina-Terol, Grecia J.; Beltrán-Ornelas, Jesús H.; Sánchez-López, Araceli; Silva‐Velasco, Diana L.; Centurión, David

doi:10.1016/j.ejphar.2019.172707

Cited by 20 publications

(8 citation statements)

References 44 publications

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“…It has been indicated that L-cysteine can upregulate GSH levels and improve oxidative stress in a high-glucose cultured hepatocyte model and in diabetic fatty liver rats [94]. Longterm supplementation with L-cysteine restores cardiovascular lesions caused by a high-fat diet in rats [95]. Dietary supplementation with L-cysteine dose-dependently promoted the antioxidant enzyme activity and decreased lipid levels in the serum and rat liver [96].…”

Section: Cysteine and Methionine Metabolismmentioning

confidence: 99%

Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism

Miao

Guo

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Many studies have found that the dysfunction in gut microbiota and the metabolic dysfunction can promote nonalcoholic fatty liver disease (NAFLD) development. Er-Chen decoction (EC) can be used in the treatment of NAFLD. However, the mechanism of this hepatoprotection is still unknown. In this study, we constructed a rat model with NAFLD fed with high-fat chow and administered EC treatment. The therapeutic effects of EC on NAFLD were evaluated by measuring transaminases, blood lipid levels, and pathological changes in the liver. In addition, we measured the effects of EC on liver inflammatory response and oxidative stress. The changes in gut microbiota after EC treatment were studied using 16S rRNA sequencing. Serum untargeted metabolomics analysis was also used to study the metabolic regulatory mechanisms of EC on NAFLD. The results showed that EC decreased the serum transaminases and lipid levels and improved the pathological changes in NAFLD rats. Furthermore, EC enhanced the activities of SOD and GSH-Px and decreased MDA level in the liver. EC treatment also decreased the gene and protein levels of IL-6, IL-1β, and TNF-α in the liver and serum. The 16S rRNA sequencing and untargeted metabolomics indicated that EC treatment affected the gut microbiota and regulated serum metabolism. Correlation analysis showed that the effects of EC on taurine and hypotaurine metabolism, cysteine and methionine metabolism, and vitamin B6 metabolism pathways were associated with affecting in the abundance of Lactobacillus, Dubosiella, Lachnospiraceae, Desulfovibri, Romboutsia, Akkermansia, Intestinimonas, and Candidatus_saccharimonas in the gut. In conclusion, our study confirmed the protective effect of EC on NAFLD. EC could treat NAFLD by inhibiting oxidative stress, reducing inflammatory responses, and improving the dysbiosis of gut microbiota and the modulation of the taurine and hypotaurine metabolism, cysteine and methionine metabolism, and vitamin B6 metabolism pathways in serum.

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Section: Cysteine and Methionine Metabolismmentioning

confidence: 99%

Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism

Miao

Guo

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…L‐Cysteine is involved in the reduction process of cells and the metabolism of phospholipids in the liver, which can protect liver cells from damage, restore liver function and promote the detoxification effect of liver. Chronic treatment with L‐cysteine can reduce adipose tissue and ameliorate the cardiovascular changes induced by obesity 38 . Furthermore, alanine, a metabolite of L‐cysteine, increases from juvenile to adult stages.…”

Section: Discussionmentioning

confidence: 99%

“…L-cysteine can reduce adipose tissue and ameliorate the cardiovascular changes induced by obesity. 38 Furthermore, alanine, a metabolite of L-cysteine, increases from juvenile to adult stages.…”

Section: Con Clus Ionmentioning

confidence: 99%

Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat

Liu

Chen

Wang

et al. 2023

Anim Models and Exp Med

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BackgroundThe purpose of our study was to study the composition and content of the feline plasma metabolome revealing the critical metabolites and metabolic pathways associated with age during growth and development.MethodsBlood samples were collected from juvenile and adult groups for blood routine tests and serum biochemistry tests. Non‐targeted metabolomics analyses of plasma were also performed to investigate changes in metabolites and metabolic pathways.ResultsIn this study, we found that the red blood cell counts, liver function indexes (albumin and gamma‐glutamyl transpeptidase), and the concentration of triglyceride and glucose changed significant with growth and development. The metabolomics results revealed that 1427 metabolites were identified in the plasma of young and adult cats. Most of these metabolites belong to major classes of lipids and lipid‐like molecules. The most obvious age‐related metabolites include reduced levels of chenodeoxycholate, taurocholate, cholate, and taurochenodeoxycholate but increased levels of L‐cysteine and taurocyamine in the adult cat's serum. These metabolites are mainly involved in the primary bile acid biosynthesis pathway, the bile secretion pathway, and the taurine and hypotaurine metabolism pathway.ConclusionThis study revealed many age‐related metabolite alterations in the feline plasma. These age‐varying metabolites, especially in the bile acid biosynthesis and secretion metabolism pathways, indicate that the regulation of these pathways is involved in the growth and development of cats. This study promotes our understanding of the mechanism of feline growth and provides new insights into nutrition and medicine for cats of different ages.

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“…It has been suggested that high concentrations of H 2 S may exert a rapid “knockdown” effect, perhaps because high concentrations of H 2 S cause transient inhibition of complex IV, resulting in inhibition of mitochondrial respiration [ 161 ]. In previous studies, NaHS treatment (100 µmol kg −1 day −1 ) for 4 weeks reversed diabetes–induced vascular dysfunction in mouse aortas [ 100 ] and ameliorated the cardiovascular changes induced by obesity [ 164 ]. However, it is worth noting that the NaHS was injected intraperitoneally, which may have led to a high initial circulating concentration of H 2 S followed by a decline and would not have provided 24–hour “coverage” for H 2 S delivery in vivo [ 161 ].…”

Section: Methodology Of Preclinical Workmentioning

confidence: 99%

The roles of hydrogen sulfide in renal physiology and disease states

Feng

et al. 2022

Renal Failure

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Hydrogen sulfide (H 2 S), an endogenous gaseous signaling transmitter, has gained recognition for its physiological effects. In this review, we aim to summarize and discuss existing studies about the roles of H 2 S in renal functions and renal disease as well as the underlying mechanisms. H 2 S is mainly produced by four pathways, and the kidneys are major H 2 S–producing organs. Previous studies have shown that H 2 S can impact multiple signaling pathways via sulfhydration. In renal physiology, H 2 S promotes kidney excretion, regulates renin release and increases ATP production as a sensor for oxygen. H 2 S is also involved in the development of kidney disease. H 2 S has been implicated in renal ischemia/reperfusion and cisplatin–and sepsis–induced kidney disease. In chronic kidney diseases, especially diabetic nephropathy, hypertensive nephropathy and obstructive kidney disease, H 2 S attenuates disease progression by regulating oxidative stress, inflammation and the renin–angiotensin–aldosterone system. Despite accumulating evidence from experimental studies suggesting the potential roles of H 2 S donors in the treatment of kidney disease, these results need further clinical translation. Therefore, expanding the understanding of H 2 S can not only promote our further understanding of renal physiology but also lay a foundation for transforming H 2 S into a target for specific kidney diseases.

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Chronic administration of NaHS and L-Cysteine restores cardiovascular changes induced by high-fat diet in rats

Cited by 20 publications

References 44 publications

Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism

Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism

Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat

The roles of hydrogen sulfide in renal physiology and disease states

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