Chronic Administration of Tribulus terrestris Linn. Extract Improves Cardiac Function and Attenuates Myocardial Infarction in Rats

Ojha, Shreesh; Nandave, Mukesh; Arora, Sachin; Narang, Rajeev; Dinda, Amit Kumar; Arya, Dharamvir Singh

doi:10.3923/ijp.2008.1.10

Cited by 51 publications

(33 citation statements)

References 26 publications

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“…Since ancient times, medicinal plants are believed to exhibit antioxidant activity and established to play a major role in the management of different diseases in humans, including cardiovascular diseases (CVDs). 22 Arbutin (ARB) is a glycosylated hydroquinone, found in various plant species, such as Bergenia crassifolia (Saxifragaceae), leaves of bearberry (Ericaceae), and pear trees (Rosaceae). 23 ARB has been used in numerous skin whitening and depigmenting cosmetics and is effective for the treatment of urinary tract infections, prevents asthma, and relieves cough.…”

Section: Introductionmentioning

confidence: 99%

Arbutin prevents alterations in mitochondrial and lysosomal enzymes in isoproterenol-induced myocardial infarction: An in vivo study

2020

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The present study demonstrated the protective effects of arbutin (ARB) on hyperlipidemia, mitochondrial, and lysosomal membrane damage and on the DNA damage in rats with isoproterenol (ISO)-induced myocardial infarction (MI). Rats were pretreated with ARB (25 and 50 mg/kg body weight (bw)) for 21 days. After pretreatment with ARB, MI was induced by subcutaneous injection of ISO (60 mg/kg bw) for two consecutive days at an interval of 24 h. The levels of TC, TG, and FFA were increased and decreased the level of PL in the heart tissue of ISO-induced MI rats. Very-low-density lipoprotein cholesterol and low-density lipoprotein cholesterol were increased while high-density lipoprotein cholesterol was decreased in the plasma of ISO-administered rats. A heart mitochondrial fraction of the ISO rats showed a significant decrease in the activities of mitochondrial enzymes isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase. The activities of lysosomal enzymes (β-glucosidase, β-glucuronidase, α-galactosidase, β-galactosidase, cathepsin-B, and cathepsin-D) were increased significantly in the heart tissue homogenate of disease control rats. In ISO-induced MI, rat’s significant increase in the percentage of tail DNA and tail length, and a decrease in the level of head DNA were also observed. ARB administration to MI rats brought all these parameters to near normality, showing the protective effect of ARB against MI in rats. The results of this study demonstrated that the 50 mg/kg bw of ARB shows higher protection than 25 mg/kg bw against ISO-induced damage.

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Section: Introductionmentioning

confidence: 99%

Arbutin prevents alterations in mitochondrial and lysosomal enzymes in isoproterenol-induced myocardial infarction: An in vivo study

2020

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“…[ 4 ] In cardiomyopathy, TT extract administration restored endogenous myocardial antioxidant status or free radical scavenging activity. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage

Rajendar

Bharavi²,

Rao

et al. 2011

Indian J Pharmacol

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Aim:The aim of the present study was to investigate whether Tribulus terrestris Linn (TT) could protect the cadmium (Cd)-induced testicular tissue peroxidation in rats and to explore the underlying mechanism of the same.Materials and Methods:In vitro and in vivo studies were conducted to know the protective effect of ethanolic extract of TT (eTT) in Cd toxicity. In in vitro studies, total antioxidant and ferrous metal ion chelating activity of TT was studied. In vivo studies were conducted in rats. A total of 40 Wistar strain adult male rats were divided into four groups. Group 1 served as control, while group 2 to 4 received CdCl2 (3 mg/kg b. wt. s/c once a week). In addition to Cd, group 3 and 4 rats also received eTT (5 mg/kg b.wt. daily as oral gavage) and α-tocopherol (75 mg/kg daily by oral gavage), respectively. At the end of 6th week, all the rats were sacrificed and the separated testes were weighted and processed for estimation of tissue peroxidation markers, antioxidant markers, functional markers, and Cd concentration. The testes were also subjected to histopathological screening.Results:In in vitro studies, the percentage of metal ion chelating activity of 50 μg/ml of eTT and α-tocopherol were 2.76 and 9.39, respectively, and the antioxidant capacity of eTT was equivalent to 0.063 μg of α-tocopherol/μg of eTT. In in vivo studies, administration of Cd significantly reduced the absolute and relative testicular weight, antioxidant markers such as superoxide dismutase and glutathione, and functional markers such as LDH and ALP, along with significant increase in peroxidation markers such as malondialdehyde and protein carbonyls in testicular tissue. Testes of Cd only-treated group showed histological insults like necrotic changes in seminiferous tubules and interstitium, shrunken tubules with desquamated basal lamina, vacuolization and destruction of sertoli cells, and degenerating Leydig cells. This group also had higher Cd levels in testicular tissue. Co-treatment with eTT and α-tocopherol significantly reduced the Cd burden in the testes along with reversal of the Cd-induced changes.Conclusions:eTT exhibited protective effect against Cd-induced testicular damage. The protective effect appears to be mediated through inhibition of testicular tissue peroxidation by antioxidant and metal chelator activity and also, may be indirectly by stimulating the testosterone production from Leydig cells.

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“…Various studies proved that cardio protective plants significantly prevented the altered biochemical variation such as marker enzymes serum glutamate pyruvate transaminase (SGPT) or alanine transaminase (ALT), serum glutamate oxaloacetate transaminase (SGOT) or aspartate transaminase (AST), creatine phosphokinase (CPK), alkaline phosphatise (ALP), lactate dehydrogenase (LDH), lipid profile including low density lipoprotein (LDL), VLDL (very low density lipoprotein), triglycerides (TGs), high density lipoprotein (HDL), total cholesterol and antioxidant parameters including Superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), Glutathione peroxidase (GPx), MDA (malonaldialdehyde) and glutathione reductase (GR) come to near normal status. Cardio protective activity was evaluated using various pharmacological screening models like isoprenaline induced myocardial necrosis in rats, doxorubicin (DOX) induced cardiotoxicity in albino rats, Cyclophasphamide induced oxidative myocardial injury in a rat model, ischemia -reperfusion induced myocardial infarction in albino rats, cigarette smoke exposed Rats, adriamycin induced cardiomyopathy in rats etc [20][21][22][23][24][25][26][27] . In one study ethanolic extract of Lagenaria siceraria fruits also showed increased in force of contraction and decrease in rate of contraction from 66 to 44 in isolated frog heart when perused with normal ringer solution.…”

Section: Resultsmentioning

confidence: 99%

EVALUATION OF CARDIOTONIC ACTION OF ETHANOL EXTRACT OF LAGENARIA SICERARIA PULP ON FROGâ€™S HEART

Tirumalasetti¹,

Harini²,

Kumar³

et al. 2014

Int. Res. J. Pharm.

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The aim of this study is to the Herbal remedies are used worldwide for various diseases. They are safer and less expensive with lesser side effects than synthetic drugs. Lagenaria siceraria, the vegetable gourd, belonging to the family Cucurbitaceae is used as diuretic, cardio-tonic, cardio-protective and nutritive agent and traditionally in the treatment of jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure and skin diseases. The present study was carried out to evaluate the cardiotonic effect of ethanol extract of pulp of Lagenaria siceraria (EELSP) in Amphibians such as the grass frog Rana pipiensin. After toxicity evaluation in albino rats two doses of the ethanol extract of Lagenaria siceraria pulp extracted with 90 % methanol using a Soxhelts apparatus was selected for the experiment. One grass Rana pipiensin frogs were taken and double pitching was done. Frog heart in situ was setup following standard procedures. Frog's ringer, Acetyl choline, Adrenalin and ¼ th Ca followed by two doses of EELSP was given one after the one and the graphing was recorded. The extract at 400 mg and 800 mg produced significant cardiotonic action. Thus the study elucidates that ethanol extract of Lagenaria siceraria pulp possess cardiotonic action at the doses of 400 and 800 mg.

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Chronic Administration of Tribulus terrestris Linn. Extract Improves Cardiac Function and Attenuates Myocardial Infarction in Rats

Cited by 51 publications

References 26 publications

Arbutin prevents alterations in mitochondrial and lysosomal enzymes in isoproterenol-induced myocardial infarction: An in vivo study

Arbutin prevents alterations in mitochondrial and lysosomal enzymes in isoproterenol-induced myocardial infarction: An in vivo study

Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage

EVALUATION OF CARDIOTONIC ACTION OF ETHANOL EXTRACT OF LAGENARIA SICERARIA PULP ON FROGâ€™S HEART

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