Chronic adult food protein–induced enterocolitis syndrome

González-Delgado, Purificación; Ruano-Zaragoza, María; Gutiérrez, Ana; Lopez, Fatima Perez; Fernández, J.

doi:10.1016/j.anai.2020.08.009

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…Hen's egg, cow's milk, and fish have been reported as causative foods for chronic FPIES. [30][31][32][33][34] More than half of patients with FPIES in the United States react to more than one food, 16,35 whereas the percentage of patients with FPIES who react to multiple foods in other countries ranges from 6% to 32%. 5,10,12,19 Many cases of IgE-mediated food allergy are crossantigenic to fish, with similar allergic reactions to many different species of fish.…”

Section: Food Triggersmentioning

confidence: 99%

Food Protein-induced Enterocolitis Syndrome

Akashi

2023

Keio J. Med.

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Food protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in recent years. Most patients develop the disease in infancy. The natural history of FPIES is generally favorable, with most FPIES cases resolving before school age. FPIES is diagnosed using symptoms such as vomiting or diarrhea, or via an oral food challenge (OFC). Currently, no validated biomarker is available for diagnosis, and the mechanisms related to gastrointestinal manifestations and immune system involved in the development of FPIES have not yet been elucidated. Treatment with intravenous fluids and ondansetron is recommended in the acute phase. Long-term management consists of complete causative food elimination and periodic OFC to confirm tolerance. Given that many diagnoses are delayed because of a lack of awareness of the condition, FPIES must be widely recognized by healthcare providers. In the future, it is expected that FPIES pathogenesis will be further clarified, and more objective diagnostic criteria will be developed.

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Section: Food Triggersmentioning

confidence: 99%

Food Protein-induced Enterocolitis Syndrome

Akashi

2023

Keio J. Med.

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“…Until recently, only the acute form of FPIES was thought to occur in adults; however, two case reports have emerged in recent years that may change this view [ 29 , 32 ].…”

Section: Chronic Fpies In Adultsmentioning

confidence: 99%

“…A case of a 20-year-old man who was admitted to hospital after several days of significant weakness, dizziness, feeling of swirling surroundings and blurred vision was also reported in 2020 [ 32 ]. Additionally, he reported chronic abdominal pain, diarrhoea and vomiting for several months.…”

Section: Chronic Fpies In Adultsmentioning

confidence: 99%

Food protein induced enterocolitis syndrome in adults

Kuźmiński¹,

Przybyszewska²,

Bartuzi³

2023

pdia

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Food protein induced enterocolitis syndrome (FPIES) belongs to a group of IgE-independent food allergies. It is the domain of paediatric patients, but it can also occur in adults. In this disease there is a life-threatening risk resulting from the possibility of a severe course of the disease and the development of hypovolemic shock. The disease was first defined in the mid-1970s. Knowledge about this disease is extremely low, we do not know its exact frequency, and the disease itself usually appears between 2 and 7 months of age. FPIES occurs mainly in formula-fed infants, typically 1-4 weeks after formula introduction, very rarely in breastfed infants, but may also develop in adults.

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“…Both acute and chronic FPIES have traditionally been a disease commonly seen in the pediatric population. However, in adults, both the acute and chronic forms have been recognized and reports have been published ( 10 – 14 ). Thus, the diagnosis of FPIES is no longer limited to a specific age group.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Symptom presentation would typically consist of abdominal pain, cramping, diarrhea and/or vomiting consistent with an acute FPIES episode. There have been reports of chronic diarrhea and weight loss consistent with chronic FPIES ( 13 , 14 ). In, their report on 24 adult FPIES patients, Crespo and colleagues demonstrated that the clinical profile for adult FPIES was more frequently associated with abdominal pain and/or diarrhea.…”

Section: Clinical Presentationmentioning

confidence: 99%

Adult Food Protein-Induced Enterocolitis Syndrome

Anvari

Ruffner

2022

Front. Allergy

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Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE, cell-mediated food allergy, commonly diagnosed in infants and young children. In recent years, new-onset adult FPIES has been recognized. The underlying pathogenic mechanism of FPIES has yet to be elucidated, thus disease-specific diagnostic biomarkers have yet to be determined and an oral food challenge (OFC) remains the gold-standard for the diagnosis. Pediatric patients with FPIES classically present with symptoms of delayed, repetitive vomiting approximately 1 to 4 hours following ingestion of a food allergen. However, adults with FPIES have been reported to have a different symptom profile and different food triggers compared to the pediatric FPIES population. The current FPIES diagnostic criteria may not be appropriate for the diagnosis of adult FPIES patients, thus an oral food challenge remains a diagnostic tool. This review provides an overview of the current literature on the clinical presentation, epidemiology, diagnosis, triggers and management of adult FPIES.

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Chronic adult food protein–induced enterocolitis syndrome

Cited by 18 publications

References 8 publications

Food Protein-induced Enterocolitis Syndrome

Food Protein-induced Enterocolitis Syndrome

Food protein induced enterocolitis syndrome in adults

Adult Food Protein-Induced Enterocolitis Syndrome

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