Chronic aerobic swimming exercise promotes functional and morphological changes in rat ileum

Araujo, Layanne Cabral da Cunha; Souza, Iara Leão Luna de; Vasconcelos, Luiz Henrique César; Brito, Aline de Freitas; Queiroga, Fernando Ramos; Silva, Alexandre; Silva, Patrícia Mirella da; Cavalcante, Fabiana de Andrade; Silva, Bagnólia Araújo da

doi:10.1042/bsr20150001

Cited by 13 publications

(10 citation statements)

References 60 publications

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“…Numerous investigations aimed to examine the influence of aerobic exercise on oxidative stress markers were mostly focused on treadmill or cycle ergometer (Powers et al 2016). We've chosen to examine the effects of swimming training due to the fact that swimming is considered as a natural ability of rats and it has also been proposed as a convenient model for studying the physiological changes and stress response to training (Balci and Pepe 2012;Araujo et al 2015).…”

Section: Levels Of Reduced Glutathione (Gsh)mentioning

confidence: 99%

Comparison of training and detraining on redox state of rats: gender specific differences

Bradić¹,

Ruzicić²,

Jeremić³

et al. 2018

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Given the fact that oxidative stress response induced by training/detraining has still not been clarified and may be influenced by gender, the aim of our investigation was to compare the effects of swimming training and detraining on oxidative and antioxidative parameters in rats, with a special focus on sex differences. Wistar albino rats (n = 64) were divided into 4 groups: control, trained group, groups exposed to 2 and 4 weeks of detraining. Each group included two subgroups: males and females. After sacrificing, hearts were isolated and retrogradely perfused according to Langendorff technique. Levels of superoxide anion radical, hydrogen peroxide, nitrites and thiobarbituric acid reactive substances were measured in plasma and coronary venous effluent, while reduced glutathione, activities of superoxide dismutase and catalase were measured in erythrocytes. Our results indicate that swimming training doesn't promote oxidative damage, nor act protectively within the heart. However, 2 and 4 weeks of detraining led to a partial lost in exercise-induced adaptation. It seems that moderate-intensity physical exercise of sufficient duration leads to beneficial adaptations, which may be partially lost during detraining period. Positive antioxidative effects of training remained longer in males. Findings of present study may help in elucidation of training and detraining effects on modulation of redox homeostasis, especially from aspect of gender differences.

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Section: Levels Of Reduced Glutathione (Gsh)mentioning

confidence: 99%

Comparison of training and detraining on redox state of rats: gender specific differences

Bradić¹,

Ruzicić²,

Jeremić³

et al. 2018

gpb

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“…However, concerning the gastrointestinal tract, little is known about the effects of physical exercise. The exercise promotes ischemia and motor changes in the intestine and intestinal mucosa [35], and shows that swimming as an acute and chronic aerobic exercise reduces ileum reactivity to both KCl and CCh [15,16]; however the influence of anaerobic exercise of resistance was not evaluated so far.…”

Section: Discussionmentioning

confidence: 99%

“…Studies of acute and chronic swimming exercise have shown that acute exercise does not promote oxidative stress in rat ileum. Furthermore, there is an increase after four weeks of exercise, but after six to eight weeks, oxidative stress is reduced, showing that the body underwent physiological changes to adapt to exercise and returned to homeostasis [15,16]. However, regarding the strength exercise, there are not data showing its effect on the balance oxidative stress and antioxidant defenses.…”

Section: Discussionmentioning

confidence: 99%

“…Physical exercise has been recommended as a therapeutic tool for the prevention and treatment of diseases and disorders of the gastrointestinal tract. The acute and chronic aerobic swimming exercise modifies the contractile gastrointestinal reactivity, thus contributing to the improvement of these gastrointestinal symptoms [15,16]. However, nothing has been demonstrated about the influence of anaerobic exercise of resistance on intestinal contractility, and the effects of the combination of exercise and S. platensis supplementation.…”

Section: Introductionmentioning

confidence: 99%

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Spirulina Platensis Supplementation Coupled to Strength Exercise Improves Redox Balance and Reduces Intestinal Contractile Reactivity in Rat Ileum

et al. 2020

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The blue alga Spirulina platensis has presented several pharmacological activities, highlighting its actions as an anti-inflammatory and antioxidant. In addition, there are few studies with the influence of strength training on physiological parameters, as intestinal contractility and oxidative cell damage. We evaluated the influence of S. platensis supplementation, strength training, and its association on contractile reactivity of rat ileum, as well as the balance of oxidative stress/antioxidant defenses. Methods: Male Wistar rats were divided into; sedentary (S); S + supplemented with algae at 50 (S50), 150 (S150), and 500 mg/kg (S500); trained (T); and T + supplemented (T50, T150, and T500). Contractile reactivity was analyzed by kymographs; oxidative stress on ileum by the malondialdehyde (MDA) formation; and the antioxidant capacity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. S. platensis supplementation reduced the reactivity of rat ileum to carbachol (CCh) and KCl, while training reduced only the CCh efficacy. In addition, association potentiated the reduction on contractile reactivity. Supplementation reduced the oxidative stress and increased oxidation inhibition; training alone did not alter this parameter, however association potentiated this beneficial effect. Therefore, this study demonstrated that both supplementation and its association with strength training promote beneficial effects regarding intestinal contractile reactivity and oxidative stress, providing new insights for intestinal disorders management.

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“…Regarding the effects of aerobic exercise on gastrointestinal tract, some studies have shown this influence on intestinal contractile responsiveness in a chronic approach (Rosa et al, 2005 ; de Lira et al, 2008 ; Araujo et al, 2015 ). On the other hand, studies focus on the acute effects of exercise on absorption of nutrients, intestinal mucosa, and gastrointestinal permeability (Pals et al, 1997 ; Lambert et al, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Acute Aerobic Swimming Exercise Induces Distinct Effects in the Contractile Reactivity of Rat Ileum to KCl and Carbachol

et al. 2016

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Aerobic exercise promotes short-term physiological changes in the intestinal smooth muscle associated to the ischemia-reperfusion process; however, few studies have demonstrated its effect on the intestinal contractile function. Thus, this work describes our observations regarding the influence of acute aerobic swimming exercise in the contractile reactivity, oxidative stress, and morphology of rat ileum. Wistar rats were divided into sedentary (SED) and acutely exercised (EX-AC) groups. Animals were acclimated by 10, 10, and 30 min of swimming exercise in intercalated days 1 week before exercise. Then they were submitted to forced swimming for 1 h with a metal of 3% of their body weight attached to their body. Animals were euthanized immediately after the exercise section and the ileum was suspended in organ baths for monitoring isotonic contractions. The analysis of lipid peroxidation was performed in order to determinate the malondialdehyde (MDA) levels as a marker of oxidative stress, and intestinal smooth muscle morphology by histological staining. Cumulative concentration-response curves to KCl were altered in the EX-AC with an increase in both its efficacy and potency (Emax = 153.2 ± 2.8%, EC50 = 1.3 ± 0.1 × 10−2 M) compared to the SED group (Emax = 100%, EC50 = 1.8 ± 0.1 × 10−2 M). Interestingly, carbachol had its efficacy and potency reduced in the EX-AC (Emax = 67.1 ± 1.4%, EC50 = 9.8 ± 1.4 × 10−7 M) compared to the SED group (Emax = 100%, EC50 = 2.0 ± 0.2 × 10−7 M). The exercise did not alter the MDA levels in the ileum (5.4 ± 0.6 μ mol/mL) in the EX-AC compared to the SED group (8.4 ± 1.7 μ mol/mL). Moreover, neither the circular nor the longitudinal smooth muscle layers thickness were modified by the exercise (66.2 ± 6.0 and 40.2 ± 2.6 μm, respectively), compared to the SED group (61.6 ± 6.4 and 34.8 ± 3.7 μm, respectively). Therefore, the ileum sensitivity to contractile agents is differentially altered by the acute aerobic swimming exercise, without affecting the oxidative stress and the morphology of ileum smooth muscle.

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Chronic aerobic swimming exercise promotes functional and morphological changes in rat ileum

Cited by 13 publications

References 60 publications

Comparison of training and detraining on redox state of rats: gender specific differences

Comparison of training and detraining on redox state of rats: gender specific differences

Spirulina Platensis Supplementation Coupled to Strength Exercise Improves Redox Balance and Reduces Intestinal Contractile Reactivity in Rat Ileum

Acute Aerobic Swimming Exercise Induces Distinct Effects in the Contractile Reactivity of Rat Ileum to KCl and Carbachol

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