Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats

Dixit, Madhura P.; Sammeta, Shivkumar S.; Dhokne, Mrunali D.; Mangrulkar, Shubhada V.; Upadhya, Manoj A.; Umekar, Milind J.; Taksande, Brijesh G.; Kotagale, Nandkishor R.

doi:10.1016/j.brainresbull.2022.10.013

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Additionally, endogenous AGM has shown positive effects in anxiety-like and depression-like behaviors induced by progesterone withdrawal (Vinchurney et al, 2023). Recent research evidence also indicates beneficial therapeutic effects of exogenous AGM in situations such as anxiety and depression induced by tobacco withdrawal (Kotagale et al, 2015), olanzapine-induced obesity and metabolic disruptions (Dixit et al, 2022), epilepsy seizures, and neuronal loss (Li et al, 2021). Recent studies on the pharmacokinetics of AGM have shown that oral administration of AGM can prolong the plasma half-life compared to intravenous administration, with a maximum reaching up to 117 min, and a bioavailability of approximately 29%-35%.…”

Section: Prenatal Use Of Agm Can Activate the Erk/creb/bdnf Pathwaymentioning

confidence: 99%

The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway

Chen,

Xu,

Zhao

et al. 2024

Birth Defects Research

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BackgroundAccording to reports, prenatal exposure to valproic acid can induce autism spectrum disorder (ASD)‐like symptoms in both humans and rodents. However, the exact cause and therapeutic method of ASD is not fully understood. Agmatine (AGM) is known for its neuroprotective effects, and this study aims to explore whether giving agmatine hydrochloride before birth can prevent autism‐like behaviors in mouse offspring exposed prenatally to valproic acid.MethodsIn this study, we investigated the effects of AGM prenatally on valproate (VPA)‐exposed mice. We established a mouse model of ASD by prenatally administering VPA. From birth to weaning, we evaluated mouse behavior using the marble burying test, open‐field test, and three‐chamber social interaction test on male offspring.ResultsThe results showed prenatal use of AGM relieved anxiety and hyperactivity behaviors as well as ameliorated sociability of VPA‐exposed mice in the marble burying test, open‐field test, and three‐chamber social interaction test, and this protective effect might be attributed to the activation of the ERK/CREB/BDNF signaling pathway.ConclusionTherefore, AGM can effectively reduce the likelihood of offspring developing autism to a certain extent when exposed to VPA during pregnancy, serving as a potential therapeutic drug.

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Section: Prenatal Use Of Agm Can Activate the Erk/creb/bdnf Pathwaymentioning

confidence: 99%

The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway

Chen,

Xu,

Zhao

et al. 2024

Birth Defects Research

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Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health

Wankhede,

Rajendra Kopalli,

Dhokne

et al. 2024

Mitochondrion

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Systematic analysis of the results of fundamental and clinical studies of ethifoxin

Gromova¹,

Torshin²

2023

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats

Cited by 3 publications

References 65 publications

The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway

The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway

Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health

Systematic analysis of the results of fundamental and clinical studies of ethifoxin

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