Chronic airflow obstruction and markers of systemic inflammation: Results from the BOLD study in Iceland

Thorleifsson, Sigurdur; Margretardottir, Olof Birna; Guðmundsson, Gunnar; Ólafsson, Ísleifur; Benediktsdóttir, Bryndís; Janson, Christer; Buist, A. Sonia; Gíslason, Þórarinn

doi:10.1016/j.rmed.2009.04.005

Cited by 73 publications

(73 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,11,48 This association has been demonstrated in a number of populations, including young, disease-free individuals, the elderly, and populations with and without COPD, but other than in this and our previous report, SCI has not been studied previously. The specific inflammatory biomarkers examined have varied across these studies, but CRP and IL-6 are the most consistently examined.…”

Section: Discussionmentioning

confidence: 46%

See 1 more Smart Citation

Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury

Hart

Morse

Tun

et al. 2015

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Context/Objective: Systemic inflammation, and to a lesser extent oxidative stress, have been associated with reduced pulmonary function. Our objective was to evaluate the associations between biomarkers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6)) and novel makers of global oxidative stress (fluorescent oxidation products (FLOx)) with spirometric and lung volume measures in individuals with chronic spinal cord injury (SCI). Design: Cross-sectional study. Setting: Veterans Affairs Medical Center. Participants: One-hundred thirty-seven men with chronic SCI participating in an epidemiologic study. Methods: Participants provided a blood sample, completed health questionnaires, and underwent pulmonary function testing, including helium dilution measurement of functional residual capacity (FRC). General linear models were used to model associations between increasing quartiles of inflammation or oxidative stress with each outcome measure, after adjustment for a number of potential confounders. Outcome Measures: Percent-predicted forced vital capacity in one second (FEV 1 ), percent-predicted forced vital capacity (FVC), FEV 1 /FVC, percent-predicted residual volume (RV), percent-predicted FRC, and percent-predicted total lung capacity (TLC). Results: After adjustment for a number of confounders, participants with higher levels of CRP and IL-6 had lower percent-predicted FEV 1 and FVC measurements. There were no clear patterns of association with any of the oxidative stress biomarkers or other outcome measures. Conclusion: Increased systemic inflammation was associated with reductions in FEV 1 and FVC independent of a number of covariates. Although the mechanism is uncertain, these results suggest that reductions in pulmonary function in SCI are associated with systemic inflammation.

show abstract

Section: Discussionmentioning

confidence: 46%

“…[1][2][3][4][5][6][7][8][9][10][11] Some, [12][13][14][15] but not all, 16,17 longitudinal studies have observed such associations. Fewer studies have demonstrated cross-sectional associations with biomarkers of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury

Hart

Morse

Tun

et al. 2015

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

show abstract

“…In humans, cytokine-induced sickness behaviour includes subjective reports of lethargy and tiredness [31], while experimental animal models show behavioural markers of fatigue [32]. While some people with COPD have measurable systemic inflammation out of proportion to the severity of their airflow limitation, there is an overall association between COPD severity and derangement of inflammatory processes [33,34]. There are, of course, other explanations for fatigue in COPD patients, such as the high oxygen cost of breathing, especially in hyperinflated patients, or the limiting effect of hypoxaemia on activities.…”

Section: Discussionmentioning

confidence: 99%

Fatigue in COPD: association with functional status and hospitalisations

et al. 2012

View full text Add to dashboard Cite

This study aimed to examine the importance of fatigue as a clinical indicator in chronic obstructive pulmonary disease (COPD), by analysing its relationship with COPD severity and ability to predict risk of hospitalisation, and by comparing the intensity of fatigue in stable COPD patients with levels of fatigue reported by patients with other chronic conditions.We studied 100 consecutive patients attending assessment clinics before pulmonary rehabilitation. Both questionnaire and physiological data were collected. Partial correlations, multiple linear regressions and Cox proportional hazard models/negative binomial regressions were used to address the research questions.A significant relationship existed between fatigue and COPD severity. Fatigue reports predicted future hospitalisation risk. Compared to the lowest third of patients, the third of patients reporting the most intense fatigue showed a 10-fold increase in risk of hospitalisation (fatigue experiences hazard ratio (HR) 10.2, 95% CI 2.66-38.86; fatigue impacts HR 10.7, 95% CI 2.76-41.65). Our COPD sample reported fatigue scores of similar intensity to colorectal cancer patients and HIV-positive patients.While fatigue is significantly related to COPD functional severity, fatigue data also capture independent information. Fatigue reports can contribute to predictions of hospitalisation risk.

show abstract

“…Lung function impairment, as assessed by a reduction in the forced expiratory volume measured in the first second of exhalation (FEV1) and forced vital capacity (FVC), contributes significantly to several major health issues, such as all-cause mortality [1,2], chronic lung disease prevalence (chronic obstructive pulmonary disease (COPD) and asthma) [3,4], and death from cardiovascular disease [5]. Preservation of lung health during ageing [6] through identification of modifiable risk factors is a key research priority.…”

Section: Impaired Lung Function Is Associated With Systemic Inflammatmentioning

confidence: 99%

“…Low-grade chronic systemic inflammation, determined by elevation of C-reactive protein (CRP) and interleukin (IL)-6 is a common mechanistic pathway contributing to reduced lung function [4,5,7] and increased cardiovascular events [8,9]. Systemic inflammation is also a feature of chronic respiratory conditions including asthma and COPD [10].…”

Section: Impaired Lung Function Is Associated With Systemic Inflammatmentioning

confidence: 99%

Impaired lung function is associated with systemic inflammation and macrophage activation

et al. 2014

View full text Add to dashboard Cite

Chronic airflow obstruction and markers of systemic inflammation: Results from the BOLD study in Iceland

Abstract: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.

Cited by 73 publications

References 25 publications

Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury

Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury

Fatigue in COPD: association with functional status and hospitalisations

Impaired lung function is associated with systemic inflammation and macrophage activation

Contact Info

Product

Resources

About