Chronic Alcohol Consumption and Cerebral Indices of Oxidative Stress: Is There a Link?

Götz, Mario E.; Janetzky, Bernd; Pohli, S.; Gottschalk, A.; Gsell, W.; Tatschner, Thomas; Ransmayr, Gerhard; Leblhuber, Friedrich; Gerlach, Manfred; Reichmann, Heinz; Riederer, Peter; Böning, Jobst

doi:10.1111/j.1530-0277.2001.tb02272.x

Cited by 32 publications

(14 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Personality disorder diagnoses (DSM-IV-TR; APA, 2000) were assessed as predictors of 8-OH-DG using hierarchical linear regression analysis. Because levels of oxidative stress have been previously associated with age (Maehira, Nakama, Ohmine, & Miyagi, 2004), male sex, smoking (Black, Bot, Scheffer, & Penninx, 2016), drinking (Caimi, Carollo, & Lo Presti, 2003;Götz et al, 2001;Micallef, Lexis, & Lewandowski, 2007), major depressive disorder (Black, Bot, Scheffer, Cuijpers, & Penninx, 2015), and posttraumatic stress disorder (PTSD) (M. W. Miller & Sadeh, 2014), these were included in the model. Of note, 22 subjects met criteria for a current depressive episode, and 20 subjects met criteria for current PTSD.…”

Section: Discussionmentioning

confidence: 99%

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Lee

Gozal

Coccaro

et al. 2020

Journal of Personality Disorders

View full text Add to dashboard Cite

The authors hypothesized that personality disorders characterized by interpersonal hypersensitivity would be associated with an elevated concentration of 8-hydroxy-2'-deoxyguanosine (8-OH-DG), the oxidized form of guanine, and a biomarker of oxidative stress burden. One hundred ninety-five male and female adults underwent semistructured diagnostic interviews, completed questionnaire measures of social cognition and emotional attribution, and had blood drawn for determination of plasma 8-OH-DG. A hierarchical linear regression model revealed that narcissistic and borderline personality disorders predicted 8-OH-DG level independently of the effects of age, gender, recent alcohol and cigarette use, current major depression, and posttraumatic stress disorder. In all subjects, 8-OH-DG level was also correlated with the number of borderline personality disorder symptoms present. Narcissistic and borderline personality disorders predicted oxidative stress burden independently of potentially confounding factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Lee

Gozal

Coccaro

et al. 2020

Journal of Personality Disorders

View full text Add to dashboard Cite

show abstract

“…Alcoholism is another disorder in which oxidative stress‐mediated brain damage and a deficit in cerebral glutathione levels have been shown (Götz et al, 2001). In addition, animal models of chronic alcoholism confirm that ethanol reduces glutathione concentrations, raises TBARS levels in the brain (Montoliu et al, 1994; Raghavendra and Kulkarni, 2001), and accentuates the effects of aging (Calabrese et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain

Rougemont

Castagné

2002

J of Neuroscience Research

View full text Add to dashboard Cite

Glutathione is a major regulator of the redox equilibrium, so its deficit weakens tissue resistance to oxidants. The nervous system is particularly susceptible to oxidative insults and is therefore very dependent on its glutathione content, especially during development, when brain metabolism and growth are maximal. In addition, various pathologies affecting the nervous system involve oxidative stress, possibly associated with a diminution of glutathione concentrations. To study the involvement of glutathione in brain redox homeostasis, we set up an experimental model of chronic glutathione deficit. Developing rats were treated daily with L-buthionine-(S,R)-sulfoximine (BSO), an inhibitor of glutathione synthesis, and their brain levels of glutathione and lipid peroxidation products (TBARS) were measured. BSO induced a 40-50% glutathione deficit in the cortex, diencephalon, and pons/medulla. Despite the glutathione deficit induced by BSO, we did not observe any signs of oxidative stress. Because it is known that rats compensate for a glutathione deficit by enhancing their synthesis and tissue levels of ascorbic acid (AA), we performed the same experiment in osteogenic-disorder Shionogi (ODS) rats, a mutant strain that cannot synthetize AA. Although BSO induced a glutathione deficit of comparable intensity in the two strains of rats, it elevated TBARS levels in the diencephalon and pons/medulla only in ODS and not in nonmutant rats. These results suggest that ODS rats, which closely mimic the human redox regulation, will allow study of the long-term consequences of chronic glutathione deficit observed in various clinical situations.

show abstract

“…Oxidative stress appears to be one key factor inducing the pathogenesis of alcohol related brain damage (Gotz et al, 2001). Ethanol itself is pro-oxidant because it directly generates reactive oxygen species during its metabolism (Koop, 2006).…”

Section: Discussionmentioning

confidence: 99%

<i>COSCINIUM FENESTRATUM</i> PROTECTS AGAINST ETHANOL-INDUCED NEURODEGENERATION IN ADULT RAT BRAIN

Phachonpai

Wannanon

Thipkaew

et al. 2012

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

Alcoholism is a serious problem throughout the world. Despite intensive efforts to develop novel therapeutics for strategy efficacy against neuronal loss leading to memory impairment in alcoholism is still limited. In view of the pitfalls of psychological dependence and adverse behavioral effects of synthetic drugs, the development of low toxicity and high efficiency medicines derived from natural herbal antioxidants exhibits expansive market prospects. In this respect, Coscinium Fenestratum (C. Fenestratum; CF) could be an attractive candidate as a diet supplement for neuroprotactant against ethanol-induced neurodegeneration. Herein, we determined the neuroprotective effects of CF against ethanol-induced neuronal damage in both hippocampus and cerebral cortex. The stems of CF extract (No. HHP-2-462) were dried, refluxed with ethanoland evaporated with lyophilizer. Extract was gave a yield of 8.53%. The rats were pretreated with the extract at various doses ranging from 5, 10 and 20 mg kg −1 once daily per os, 30 min prior to ethanol administration at a dose of 1.8 g kg −1 via i.p for 14 consecutive days and were evaluated the densities of survival and cholinergic neurons in all areas as mention above by immune histological techniques. CF extract at a dose of 5 mg kg −1 showed the attenuation of the neurotoxicity in all brain areas just mentioned except in the temporal cortex. In addition, it also mitigated the degeneration of cholinergic neurons in all areas of hippocampus except in CA3 region. This study indicated that CF extract consumption may be served as a diet supplement protect against neuronal degeneration resulting from excessive continuous consumption of alcohol. However, further researches about possible active ingredients and pharmacokinetic of the extract are still required before moving forward to clinical trial study.

show abstract

Chronic Alcohol Consumption and Cerebral Indices of Oxidative Stress: Is There a Link?

Cited by 32 publications

References 65 publications

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain

<i>COSCINIUM FENESTRATUM</i> PROTECTS AGAINST ETHANOL-INDUCED NEURODEGENERATION IN ADULT RAT BRAIN

Contact Info

Product

Resources

About