Chronic Allergic Neuropathy in the Rabbit

Chronic experimental allergic neuritis (EAN) in juvenile guinea pigs: Immunological comparison with acute EAN in adult guinea pigs

“…Although the "onion bulb" formation which indicates repetitive demyelination and remyelination was more frequently observed in the juvenile chronic form than in the adult acute form, the fundamental pathological processes were almost indistinguishable from each other. Previous reports of successful induction of chronic EAN inevitably employed the multiple repetitive inoculation of antigens (14)(15)(16), though the acute form,of EAN has been induced by a single inoculation of an antigen (7,8). Because of these differences in the process of induction between chronic and acute form of EAN, direct comparison of the underlying mecha- nism which induces these 2 different clinical courses was difficult to study.…”

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

“…Several years later, an experimental model of chronic EAN was developed. 11,12 The acute and chronic EAN models provided compelling evidence that GuillainBarré syndrome and the condition that would later be called CIDP were not caused by an infectious, toxic, or spontaneous process. Waksman and Adams argued that the underlying mechanism of EAN was autoimmune; that EAN was due to an immunologic (allergic) process is in the final analysis largely based on the nature of the technique used to produce them, on the existence of the characteristic latent period, and on the inflammatory character of the lesions in the absence of an infectious agent.…”

Myelin

“…In general, the sooner after challenge the clinical signs appear, the more severe will be the disease. Repeated injections of antigen (Waksman, 1963;Sherwin, 1966) can result in a chronic relapsing form of EAN in rabbits or guinea pigs.…”