Chronic anabolic androgenic steroid usage associated with acute coronary syndrome in bodybuilder

Sönmez, Ertan; Türkdoğan, Kenan Ahmet; Yilmaz, Cahit; Kucukbuzcu, Sıtkı; ÖZKAN, Abuzer; Sogutt, Ozgur

doi:10.1016/j.tjem.2014.11.001

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…[43,44] However, supraphysiological doses cause coronary spasm. Sonmez et al [45] reported a clinical case of a 32-year-old male who had severe chest pain and was admitted to the local hospital. He had been taking AAS (200 mg weekly) for 3 years for bodybuilding.…”

Section: Effects Of Aas On the Cardiovascular Systemmentioning

confidence: 99%

Anabolic-androgenic steroids and cardiovascular risk

Liu

2019

Chinese Medical Journal

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Objective:Anabolic-androgenic steroids (AAS) represents a group of synthetic testosterone derivatives that play an important role in clinical treatment. These drugs are widely abused among the general public to increase lean weight and improve athletic performance. It has been reported that AAS use can produce many adverse effects, especially the occurrence of cardiovascular risk. Although there are many related studies, there has been no consensus on AAS use and cardiovascular risk. The present study was to review the effect of AAS on the cardiovascular system.Data sources:The data in this review were obtained from articles included in PubMed and the National Center for Biotechnology Information database.Study selection:Original articles, case reports, and systematic reviews about AAS were selected for the article.Results:The use/abuse of AAS is correlated with higher cardiovascular risks, and many AAS users/abusers had cardiovascular diseases. However, there are many confounding factors in the studies that explored the causality between AAS intake and disease development, and additional studies are required to determine AAS toxicity.Conclusion:AAS produces toxic effects on the cardiovascular system, and it is necessary to ensure that more people know this about AAS, including medical personnel.

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Section: Effects Of Aas On the Cardiovascular Systemmentioning

confidence: 99%

Anabolic-androgenic steroids and cardiovascular risk

Liu

2019

Chinese Medical Journal

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“…Hernandez et al described a case of a 24-year-old man with a history of AAS abuse who suffered a cardiorespiratory arrest and was later found to have acute MI due to severe coronary atherosclerosis and superimposed acute occlusive thrombosis at the left main trunk and left anterior descendant [2]. Whereas another case described a 32-year-old man who had acute MI due to coronary spasm from AAS use as he was found to have normal coronary arteries on an angiogram [13]. A few other case reports described young men with AAS abuse who developed acute MI and was later found to have hyperhomocysteinemia [10,14].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case Report and Literature Review of Anabolic-Androgenic Steroids (AAS)-Induced Acute Myocardial Infarction

Zhang¹,

Shan²,

Raza³

et al. 2020

Cureus

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Anabolic-androgenic steroids (AAS) abuse is common in competitive athletes in order to enhance athletic performances. However, AAS abuse is often associated with deleterious side effects including but not limited to cardiovascular diseases, depression, hormonal abnormalities, and cancer. We present a case of a 31-year-old male with a history of Crohn's disease on infliximab and chronic AAS use who had persistent retrosternal chest pain found to have an acute myocardial infarction (MI) without obvious cardiovascular risk factors.

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“…The documented evidence of the ability of AASs to increase blood thrombosis (5) may explain this event. In addition, although the vasospastic mechanism is less established as a factor in AASs-based AMI (15,16), it may possibly intensify the atherogenic or the thrombotic mechanisms of AMI in AASs users. In concordance with these data, AAS abuse has been identified to induce vascular and endothelial dysfunctions (17,18).…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction with cardiogenic shock in a young physically active physician concurrently using the anabolic steroid sustanon: A case report

2020

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The association between ischemic heart disease (IHD) and the concurrent use of anabolic androgenic steroids (AASs) is underestimated in clinical settings. The tendency of patients to not disclose AASs use may explain this underestimation. In the present case report, the clinical case of a 26-year-old physically active male, who was a physician, without any classical coronary risk factors, who presented with chest pain that was misdiagnosed by the peripheral care unit as skeletal muscle pain is described. Later, the patient was brought to our central hospital (King Abdullah University Hospital) suffering from a massive acute myocardial infarction with marked ECG changes and cardiogenic shock. Following stabilization of his condition, a detailed history of the patient was taken, during which the patient admitted that he was a chronic user of the anabolic steroid sustanon (250 mg, once/week for 6 months) and amino acid supplements (whey protein isolate, 6 tabs every day for 1 year). Specific cardiac markers were increased and the patient exhibited dynamic ischemic changes in his electrocardiogram. Notably, the coronary angiogram of the patient demonstrated ostial occlusion of the left anterior descending artery, which was associated with mid-right coronary artery embolic obstruction. Other than the anabolic steroids and protein supplementation use, the patient history, examination and lab evaluation were normal. During follow up, the patient continued to suffer heart failure with low ejection fraction. In addition, he developed apical thrombus 2 months after primary admission. The patient developed tachycardia in spite of optimal medical treatment and finally received an implantable cardioverter defibrillator. Physicians should always be aware of the possibility of AASs use in young physically active patients. IHD should always be suspected and investigated with typical chest pain in healthy young patients, even if regular risk factors are not present. Medical professionals should not be excluded as potential AASs users/abusers.

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Chronic anabolic androgenic steroid usage associated with acute coronary syndrome in bodybuilder

Cited by 16 publications

References 9 publications

Anabolic-androgenic steroids and cardiovascular risk

Anabolic-androgenic steroids and cardiovascular risk

A Rare Case Report and Literature Review of Anabolic-Androgenic Steroids (AAS)-Induced Acute Myocardial Infarction

Acute myocardial infarction with cardiogenic shock in a young physically active physician concurrently using the anabolic steroid sustanon: A case report

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