Chronic Anemia due to Gastric Ectopia within the Duodenum

Canelles, P; Ortí, E; Tomé, A; Garcia, V.; Medina, E

doi:10.1055/s-2007-1010486

Cited by 1 publication

(1 citation statement)

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“…Studies on exercise and gastric acid secretion report a decrease in fasted gastric acid secretion either during exercise or during restitution [69][70][71] . Furthermore, physical stress is known to induce a 3-fold increase in fasted gastric acid secretion 72 .…”

Section: Biological Variations and Other Factors Influencing Fasted G...mentioning

confidence: 99%

Intra- and interindividual variability in fasted gastric content volume

Roelofs,

Camps,

Leenders

et al. 2024

Preprint

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Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. Analysis included 366 participants with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). Results: FGCV ranged from 0 to 156 mL, with a mean (SD) value of 33 mL (25 mL). The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: -6 mL), when corrected for the aforementioned factors. Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.

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Section: Biological Variations and Other Factors Influencing Fasted G...mentioning

confidence: 99%