Chronic arachidonic acid eicosanoid imbalance: A common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway

Booyens, J; Merwe, CF van der; Katzeff, I.E.

doi:10.1016/0306-9877(85)90120-3

Cited by 18 publications

(7 citation statements)

References 22 publications

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“…1 Consumption of EPA has been associated with the prevention of atherosclerosis, the successful treatment of coronary artery disease, and amelioration of chronic inflammatory diseases. [2][3][4][5]…”

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confidence: 99%

Omega-3 Fatty Acids

Boutros¹

2010

Arch Surg

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Omega-3 (omega-3) fatty acids have been clinically and experimentally associated with the amelioration of chronic and acute inflammation; however, the mechanisms for these observations have not been well defined. During the past decade, laboratories of nutrition and inflammation have demonstrated that the anti-inflammatory activities of omega-3 fatty acids occur at least in part through the inhibition of macrophage-elaborated tumor necrosis factor production and through inactivation of the nuclear factor-kappaB signaling pathway subsequently altering proinflammatory cytokine transcription. These observations led to further experiments that support a role for omega-3 fatty acids in the restoration of apoptosis in various chemoresistant tumor models through a similar inactivation of the nuclear factor-kappaB signaling pathway. The potential for nutritional modulation of host inflammation has been an ongoing and expanding area of investigation. An increased emphasis has been placed on the potential for diet and dietary supplements to serve as modulators of host response to disease, injury, and infection.

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confidence: 99%

Omega-3 Fatty Acids

Boutros¹

2010

Arch Surg

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“…These beneficial clinical effects have ranged from reduced risk of acute myocardial death, 1 nutritional repletion in patients with advanced pancreatic malignancy, 2 respiratory disorders such as cystic fibrosis 3 and autoimmune syndromes. 4,5 Dietary -3 fatty acids are most commonly derived from marine fish oil, although several agricultural sources for -3 oils also exist. In fish oil-derived -3 fatty acids, the most active component is eicosapentaenoic acid (EPA) a C20⌬53 fatty acid, and for the purposes of this article, these terms (-3, fish oil, and EPA) will be used interchangeably.…”

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confidence: 99%

“…Clinically, we recognize that -3 fatty acids are essential for normal growth and development and that they may also be of benefit in a wide range of disease states, including rheumatoid arthritis, atherosclerosis, acute myocardial death, sepsis, and cancer-associated cachexia. [1][2][3][4][5] Interestingly, a common factor between these clinical conditions is endothelial inflammation, underscoring the significance of -3 fatty acids as antiinflammatory agents. A further focus of our investigations was the potential for defining independent "pharmacologic" activity for -3 fatty acids or identifying synergy between -3 fatty acids and the recently available selective cyclooxygenase (COX) -2 inhibitors; recognizing that both compounds have established antiinflammatory activities and likely common mechanisms of action.…”

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confidence: 99%

Experimental Studies Defining ω‐3 Fatty Acid Antiinflammatory Mechanisms and Abrogation of Tumor‐Related Syndromes

Babcock

Dekoj²,

Espat

2005

Nut in Clin Prac

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Clinical and experimental evidence has supported a benefit for the inclusion of fish oils (a primary source of omega-3 fatty acids) as a component of a normal healthy diet. Polyunsaturated omega-3 fatty acids have been demonstrated to be of benefit in a number of inflammation-associated disease states, including atherosclerosis, autoimmune disorders, malignancy, and sepsis. The beneficial effects of omega-3 fatty acids are thought to occur through the postulated antiinflammatory actions of omega-3 fats; however, the specific mechanism(s) of action has not been completely defined. In this review, we discuss the recent progress made in our laboratory on defining the mechanisms of omega-3 fatty acids activity.

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“…These beneficial clinical effects have ranged from reduced risk in acute myocardial death, 1 nutritional repletion in patients with advanced pancreatic malignancy, 2 respiratory disorders such as cystic fibrosis, 3 and autoimmune syndromes. 4,5 Underlying many of these conditions in which there may be a role for the inclusion of -3 lipids is the global concept of systemic inflammation. Inflammation with a significant clinical impact is generally accepted to be the result of the prolonged, inappropriate production and release of proinflammatory mediators, specifically cytokines.…”

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confidence: 99%

“…BABCOCK ET AL Vol. 28,No. 4 Ms undergo LPS stimulation in the presence of a dose equivalent -6 lipid control, no further increase in TNF-␣ production compared with media-only Ms has been observed.…”

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confidence: 99%

Synergistic anti‐inflammatory activity of omega‐3 lipid and rofecoxib pretreatment on macrophage proinflammatory cytokine production occurs via divergent NF‐kappaB activation

Babcock

Helton

Anwar

et al. 2004

J Parenter Enteral Nutr

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Omega-3 lipids and Rofecoxib independently decrease TNF-alpha and PGE2 production in LPS-stimulated Mphi, yet in combination a synergistic reduction in TNF-alpha production is observed. Although the anti-inflammatory effects observed from omega-3 lipids are known to occur partially through decreasing NF-kappaB activation, we demonstrated that Rofecoxib or even a combination of omega-3 and Rofecoxib does not alter NF-kappaB activation, as seen with omega-3 lipids alone. These data support that combination treatment may result in decreased Mphi inflammation, yet this occurs via divergent mechanisms.

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Chronic arachidonic acid eicosanoid imbalance: A common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway

Cited by 18 publications

References 22 publications

Omega-3 Fatty Acids

Omega-3 Fatty Acids

Experimental Studies Defining ω‐3 Fatty Acid Antiinflammatory Mechanisms and Abrogation of Tumor‐Related Syndromes

Synergistic anti‐inflammatory activity of omega‐3 lipid and rofecoxib pretreatment on macrophage proinflammatory cytokine production occurs via divergent NF‐kappaB activation

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