A descriptive type of cross sectional study was conducted in Sharshaupazila under Jessore district on socioeconomic condition and health status of chronic arsenicosis patients from July to October, 2011. The prevalence of arsenicosis due to arsenic contamination of ground water may emerge in the form of epidemic and chronic arsenic exposure through drinking water is one of the major environmental hazards in Bangladesh. The main source of drinking water is shallow tube well (64%) among which 21% tube well has been red marked i.e., contaminated with arsenic poisoning. About 59.8% respondents have belonged to income deficit group and their monthly income decreased significantly. The chronic effect due to arsenic poisoning is about 32% and the men (69.33%) were more susceptible to arsenicosis. Among the affected patients identified problems were melanosis (94%), keratosis (33%), leucomelanosis (38%), respiratory problem (49%), loss of sensation (45%), bowen's (21.33%), oedema (9.33%), chronic nonhealing ulcer (6.33%), lung cancer (2%), and gangrene (0.66%). About 32.94% people consulted with homeopath for their treatment and only 22.35% people consulted with government health physician. To be aware of arsenicosis the health education must be improved within the community and the financial support; relevant training could be effective to reduce the arsenic poisoning.