Chronic arterial occlusion in a canine model: a novel technique.

A Porcine Model of Carotid Artery Thrombosis for Thrombolytic Therapy and Angioplasty: Application of PTFE Graft-Induced Stenosis

“…In a ca- nine femoral artery occlusion model in which an occlusive polymer was injected intraluminally, it required at least 6 months before the polymer was degraded within the artery. 15 Other occlusive agents tested in canine iliac arteries, such as gelatin sponge and microfibrillar collagen, 16 likewise require a long time for degradation. Moreover, histological examination of these occluded vessels frequently demonstrated a prominent inflammatory reaction elicited by the foreign materials.…”

An Endovascular Model of Carotid Stenosis for the Evaluation of Thrombolysis and Angioplasty

“…Another experimental approach to induce arterial thrombosis is by intraluminal injection of thrombogenic materials, such as ferric chloride, microfibrillar collagen, or gelatin sponge. [16][17][18][19] Although these foreign materials are highly effective in creating arterial thrombosis, they typically require long periods of time for degradation. 19 Consequently, any efforts to evaluate the efficacy of antithrombotic or thrombolytic therapy may become clinically irrelevant because of the constant presence of the foreign substances.…”

“…Of note, the intraarterial injection of an occlusive polymer Nbutyl-cyanoacrylate required at least 6 months before the thrombogenic polymers were fully degraded within the circulation. 18 Moreover, histological examination of these occluded vessels frequently demonstrated a prominent inflammatory reaction elicited by the foreign materials. The inciting factor of thrombus formation in our model, by contrast, is the intraluminally tapered stenosis created by the PTFE graft, which does not elicit foreign-body reaction or chronic inflammatory response comparable to that caused by resorbable occlusive agents.…”

Birth and Growth of Neuroimaging and Vascular Intervention at Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram—Part I

“…A patient with severe short segment stenosis of the left subclavian artery in its second part presented with upper limb claudication. [10][11][12] When the angiographic image was shown to Dr. Valiathan in his office, with exuberant confidence that the lesion could be treated by balloon angioplasty, avoiding surgery, he did not hesitate to allow the authors to go ahead with the procedure, deferring his plan of surgery on the patient. Access was gained into the left axillary artery with the help of the Seldinger technique, and using textbook descriptions and literature knowledge, the focal stenosis was crossed by means of an extra-long guide wire.…”