Chronic asymptomatic hyperamylasemia unrelated to pancreatic diseases

Gallucci, Fernando; Buono, Rosario; Ferrara, L; Madrid, E; Miraglia, Simona; Uomo, Generoso

doi:10.2478/v10039-010-0049-9

Cited by 13 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Secondly, we did not perform amylase isoenzyme testing, and thus cannot differentiate between salivary and pancreatic amylase, the two major sites of amylase production. As the children in our study were clinically well, a possible explanation for their elevated amylase levels could be what is now termed chronic asymptomatic hyperamylasaemia unrelated to pancreatic diseases (CHUPD) . CHUPD can typically be classified further into macroamylasaemia, benign pancreatic hyperamylasaemia and salivary hyperamylasaemia.…”

Section: Discussionmentioning

confidence: 84%

Establishment of biochemistry reference values for healthy Tanzanian infants, children and adolescents in Kilimanjaro Region

Buchanan

Fiorillo

Omondi

et al. 2015

Tropical Med Int Health

View full text Add to dashboard Cite

Objective To establish common biochemistry reference intervals for Tanzanian infants, children, and adolescents living in the Kilimanjaro Region. Methods We recruited healthy, HIV-uninfected Tanzanian infants, children, and youth between the ages of one month and 17 years from local schools and clinics to participate in this study. Only afebrile children without signs of physical or chronic illness were enrolled. Nonparametric methods were used to determine 95% reference limits and their 90% confidence intervals, with outliers removed by the Tukey method. Results A total of 619 healthy infants, children, and adolescents were enrolled into the study. Twenty-three biochemistry parameters were measured. Compared to U.S. reference intervals, several of the biochemistry parameters showed notable differences; namely, alkaline phosphatase, phosphorus, amylase, and lipase. Comparing our data to the U.S. National Institutes of Health (NIH) Division of AIDS (DAIDS) grading criteria for classification of adverse events, we found that for select parameters, up to 15% of infants or children in certain age groups would have been categorized as having an adverse event as defined by DAIDS. Conclusions Our study further confirms the need to use locally established reference intervals to define reference laboratory parameters among children in Africa, rather than relying on those derived from U.S. or European populations. To our knowledge, this study provides the first set of locally validated biochemistry reference ranges for a pediatric population in Tanzania.

show abstract

Section: Discussionmentioning

confidence: 84%

Establishment of biochemistry reference values for healthy Tanzanian infants, children and adolescents in Kilimanjaro Region

Buchanan

Fiorillo

Omondi

et al. 2015

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…The prevalence of macroamylasemia has been estimated at 1% in normal amylasemic patients and 2.5% in hyperamylasemic patients (3). The most useful diagnostic method for identification of macroamylasemia is the evaluation of amylase levels in serum and urine together, due to the technical difficulties in performing specific agarose-gel electrophoresis (1,5). Coexistence of macroamylasemia and various diseases such as celiac disease (7), ulcerative colitis (8), Crohn's disease (9), haematological malignancies (10,11), systemic lupus erythematosus (12), and rheumatoid arthritis (13) has been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Every abdominal pain and amylase increase may not indicate pancreatitis (1,2). Hyperamylasemia is a laboratory finding that may cause diagnostic failure occasionally in patients presenting with abdominal pain.…”

Section: Introductionmentioning

confidence: 99%

A Rare Cause of Hyperamylasemia: Macroamylasemia

Çoşkun¹,

Çetin²,

Yaşa³

et al. 2017

meandros

View full text Add to dashboard Cite

“…[19,20]. Высказывается мнение о связи изменений с дефектами вирсунгианова протока [14]. Заподозрить этот синдром можно на основании отягощенного семейного анамнеза ХБПГ, приема лекарственных препаратов (парацетамол, стероиды, эфедрин, химиотерапия).…”

Section: гиперлипаземия и макролипаземияunclassified

“…Относительно недавно опубликованы результаты исследования W. Gonoi et al, в котором анализировались условия возникновения МАЕ [14]. Осуществляя плановый медицинский осмотр за когортой относительно здоровых лиц (n=554), исследователи выявили 14 пациентов с идиопатической панкреатической гиперамилаземией или гиперлипаземией.…”

Section: гиперлипаземия и макролипаземияunclassified

Secrets, puzzles and mysteries of macroamylasemia

Губергріц

Byelyayeva

Лукашевич

et al. 2020

Bul. of the Club of Pancr.

View full text Add to dashboard Cite

Physiological features of amylase synthesis and excretion are considered in the article, presence of other sources of amylase synthesis different from pancreas and salivary glands is emphasized. Definitions of hyperenzymemia and macroamylasemia (MAE) are given. MAE is a state characterized by presence of circulating complexes of normal serum amylase with protein or carbohydrates in blood. There are 3 types of MAE: first — classical (constant hyperamylasemia, decreased amylase level in urine, high blood concentration of macroamylase complexes); second — hyperamylasemia with slightly decreased amylase activity in urine, macroamylase/normal amylase ratio is less than in the first type; third — normal blood and urine amylase activity, low macroamylase/normal amylase ratio. Pathogenesis is explained by connection of blood amylase and acute phase protein in different inflammatory, infectious diseases, malabsorption. MAE clinical manifestations could be absent, sometimes abdominal pain is possible. Hyperamylasemia and reduced urine amylase activity are typical. MAE diagnostics means determination of macroamylase complexes in blood (chromatography, calculation of the clearance ratio of amylase and creatinine). The article presents clinical cases describing extra-pancreatic MAE in women with malignant ovarian lesions. The question of expediency of thorough diagnostic examination in asymptomatic MAE is raised, which may turn out to be a symptom of cancer. The lack of specific treatment for MAE is emphasized.

show abstract

Chronic asymptomatic hyperamylasemia unrelated to pancreatic diseases

Cited by 13 publications

References 11 publications

Establishment of biochemistry reference values for healthy Tanzanian infants, children and adolescents in Kilimanjaro Region

Establishment of biochemistry reference values for healthy Tanzanian infants, children and adolescents in Kilimanjaro Region

A Rare Cause of Hyperamylasemia: Macroamylasemia

Secrets, puzzles and mysteries of macroamylasemia

Contact Info

Product

Resources

About