Chronic asymptomatic pyuria precedes overt urinary tract infection and deterioration of renal function in autosomal dominant polycystic kidney disease

Hwang, Jin Ho; Park, Hayne Cho; Jeong, Jong Cheol; Baek, Seon Ha; Han, Mi Yeun; Bang, Kitae; Cho, Jeong Yeon; Yu, Sung Hoon; Yang, Jaeseok; Oh, Kook Hwan; Hwang, Young Hwan; Ahn, Curie

doi:10.1186/1471-2369-14-1

Cited by 72 publications

(73 citation statements)

References 29 publications

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“…However, several comorbidities such as cancer, arthritis, and chronic kidney disease were higher than normative values. This is expected, as each of these chronic conditions is associated with an increased risk of frailty (47–49). Because physical activity and diet quality were measured only once at baseline, it is unknown if increasing physical activity or improving diet quality would improve distal health outcomes among prefrail and frail older adults.…”

Section: Discussionmentioning

confidence: 95%

Physical Activity, Diet Quality, and Mortality among Community-Dwelling Prefrail and Frail Older Adults

Brown

Harhay

2016

Journal of Nutrition in Gerontology and Geriatrics

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It is unknown if physical activity and diet quality are associated with the risk of poor outcomes, such as mortality, among prefrail and frail older adults. This was a population-based cohort study among 1,487 prefrail and frail older-adults from the Third National Health and Nutrition Survey. Compared to participants who were sedentary (0 bouts of physical activity per week), those who were physically inactive (1–4 bouts of physical activity per week) were 24% less likely to die [HR: 0.76 (95% CI: 0.58–0.98)], and those who were physically active (≥5 bouts of physical activity per week) were 34% less likely to die [HR: 0.66 (95% CI: 0.51–0.86); Ptrend=0.002]. Compared to participants with poor diet quality, those with fair diet quality were 26% less likely to die [HR: 0.74 (95% CI: 0.52–0.98)], and those with good diet quality were 33% less likely to die [HR: 0.67 (95% CI: 0.55–1.00); Ptrend=0.050]. There was a synergistic interaction between physical activity and diet quality on the risk of mortality (Pinteraction=0.058). Participation in physical activity and consumption of a healthy diet is associated with a lower risk of mortality among prefrail and frail older adults.

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Section: Discussionmentioning

confidence: 95%

Physical Activity, Diet Quality, and Mortality among Community-Dwelling Prefrail and Frail Older Adults

Brown

Harhay

2016

Journal of Nutrition in Gerontology and Geriatrics

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“…38 A third retrospective, singlecenter study suggested that asymptomatic pyuria and particularly, overt UTI were associated with faster decline in renal function, but it is unclear whether this result was independent of other factors, such as baseline GFR and TKV. 39 In addition, overt UTI was uncommon in that study, occurring in only 33 of 256 patients during a mean observation period of 81 months. It remains, therefore, uncertain whether UTIs play a significant role in the loss of renal function in ADPKD.…”

Section: Multiple Urinary Tract Infectionsmentioning

confidence: 99%

Predictors of Autosomal Dominant Polycystic Kidney Disease Progression

Schrier

Brosnahan

Cadnapaphornchai

et al. 2014

Journal of the American Society of Nephrology

146

120

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Autosomal dominant polycystic kidney disease is a genetic disorder associated with substantial variability in its natural course within and between affected families. Understanding predictors for rapid progression of this disease has become increasingly important with the emergence of potential new treatments. This systematic review of the literature since 1988 evaluates factors that may predict and/or effect autosomal dominant polycystic kidney disease progression. Predicting factors associated with early adverse structural and/or functional outcomes are considered. These factors include PKD1 mutation (particularly truncating mutation), men, early onset of hypertension, early and frequent gross hematuria, and among women, three or more pregnancies. Increases in total kidney volume and decreases in GFR and renal blood flow greater than expected for a given age also signify rapid disease progression. Concerning laboratory markers include overt proteinuria, macroalbuminuria, and perhaps, elevated serum copeptin levels in affected adults. These factors and others may help to identify patients with autosomal dominant polycystic kidney disease who are most likely to benefit from early intervention with novel treatments.

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“…The typical concentration levels of TNF-α in human urine samples are often below the DLs of conventional cytokine detection platforms. 41 Those of IL-8, on the other hand, typically exhibit values above several tens of pg/mL and well into the ng/mL range, 42,43 which can be determined with traditional techniques. Therefore, we carried out both ELISA- and ZnO NRs-based assays from the same set of patient samples.…”

Section: Resultsmentioning

confidence: 99%

Ultratrace level determination and quantitative analysis of kidney injury biomarkers in patient samples attained by zinc oxide nanorods

et al. 2016

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Determining ultratrace amounts of protein biomarkers in patient samples in a straightforward and quantitative manner is extremely important for early disease diagnosis and treatment. Here, we successfully demonstrate the novel use of zinc oxide nanorods (ZnO NRs) in the ultrasensitive and quantitative detection of two acute kidney injury (AKI)-related protein biomarkers, tumor necrosis factor (TNF)-α and interleukin (IL)-8, directly from patient samples. We first validate the ZnO NRs-based IL-8 results via comparison with those obtained from using a conventional enzyme-linked immunosorbent method in samples from 38 individuals. We further assess the full detection capability of the ZnO NRs-based technique by quantifying TNF-α, whose levels in human urine are often below the detection limits of conventional methods. Using the ZnO NR platforms, we determine the TNF-α concentrations of all 46 patient samples tested, down to the fg/mL level. Subsequently, we screen for TNF-α levels in approximately 50 additional samples collected from different patient groups in order to demonstrate a potential use of the ZnO NRs-based assay in assessing cytokine levels useful for further clinical monitoring. Our research efforts demonstrate that ZnO NRs can be straightforwardly employed in the rapid, ultrasensitive, quantitative, and simultaneous detection of multiple AKI-related biomarkers directly in patient urine samples, providing an unparalleled detection capability beyond those of conventional analysis methods. Additional key advantages of the ZnO NRs-based approach include a fast detection speed, low-volume assay condition, multiplexing ability, and easy automation/integration capability to existing fluorescence instrumentation. Therefore, we anticipate that our ZnO NRs-based detection method will be highly beneficial for overcoming the frequent challenges in early biomarker development and treatment assessment, pertaining to the facile and ultrasensitive quantification of hard-to-trace biomolecules.

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Chronic asymptomatic pyuria precedes overt urinary tract infection and deterioration of renal function in autosomal dominant polycystic kidney disease

Cited by 72 publications

References 29 publications

Physical Activity, Diet Quality, and Mortality among Community-Dwelling Prefrail and Frail Older Adults

Physical Activity, Diet Quality, and Mortality among Community-Dwelling Prefrail and Frail Older Adults

Predictors of Autosomal Dominant Polycystic Kidney Disease Progression

Ultratrace level determination and quantitative analysis of kidney injury biomarkers in patient samples attained by zinc oxide nanorods

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