Chronic atrophic gastritis in different ages in South China: a 10-year retrospective analysis

Abstract

Objectives To explore the prevalence, characteristics, age distribution and etiology changes of chronic atrophic gastritis (CAG) in South China. Methods This study included all patients who underwent endoscopy examinations from 2011 to 2020 in our hospital. Patients were divided into groups 1 (2011–2015) and 2 (2016–2020). The prevalence, characteristics, age distribution and etiology changes of CAG were compared between groups. Results Overall CAG prevalence was 20.92% (24,084/115,110) from 2011 to 2020; prevalence significantly differed between groups (18.78%, 8468/45,087, in group 1 and 22.30%, 15,616/70,023, in group 2). Patients with CAG had significantly younger age (under 45) and more corpus atrophy and more autoimmune atrophic gastritis (AAG) in group 2 than in group 1. AAG prevalence in group 2 was 30.11% (4702/15,616) significantly higher than 13.57% (1149/8468) in group 1. 82 patients with AAG later exhibited gastric cancer without obvious clinical features over the decade. Conclusions CAG is increasing and seems starting earlier among people during the study period. We need to focus on diagnosis and treatment of corpus related atrophy and AAG, especially for the young. Laboratory examination, endoscopic biopsy and surveillance are important for CAG.

Nationwide survey ofHelicobacter pyloriseropositivity and gastric atrophy in Zambia

“…However, this was a hospital‐based study and the prevalence would be expected to be higher. In south China, gastric atrophy across all age groups was found to be 19% between 2011 and 2015, increasing to 22% between 2016 and 2020 33 . This too was a hospital‐based study, with an expected higher prevalence of gastric atrophy than the general population.…”

“…In south China, gastric atrophy across all age groups was found to be 19% between 2011 and 2015, increasing to 22% between 2016 and 2020. 33 This too was a hospital-based study, with an expected higher prevalence of gastric atrophy than the general population. A comprehensive meta-analysis of data from 19 Asian countries revealed a pooled prevalence of serologically diagnosed gastric atrophy of 28.9% (17/52,722).…”

Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats

“…During CAG, pathological changes occur in the gastric mucosal layer, causing thinning, disappearance, or thickening of the mucosal base due to atrophy of the gastric mucosal glands. It is often accompanied by inflammation and precancerous lesions, such as intestinal metaplasia (IM) and dysplasia (1)(2)(3). The progression from normal tissue to gastric cancer (GC) involves five processes: normal gastric mucosa, CAG, IM, dysplasia, and GC (4).…”