Chronic bacterial prostatitis. Clinical and microbiological study of 332 cases

Heras-Cañas, Víctor; Gutiérrez-Soto, Blanca; Serrano-García, María Luisa; Vázquez-Alonso, Fernando; Navarro-Marí, José María; Gutiérrez‐Fernández, José

doi:10.1016/j.medcle.2016.09.032

Cited by 13 publications

(12 citation statements)

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“…(45%) were the most common, followed by E. coli (27%) and Klebsiella (24%). Similar findings were also noted by Heras-Canas et al 12 A few studies have investigated the role of atypical micro-organisms such as chlamydia, mycoplasma and human papillomavirus. 16,17 However, the exact role of these is unknown at present.…”

Section: Discussionsupporting

confidence: 85%

“…6 However, Nickel et al, Heras-Canas et al and Magri et al were able to diagnose CBP microbiologically in only 18.4%, 8.0% and 13% of their cases, respectively. 8,12,13 On the other hand, Montes et al found a 79% positive rate using the four-glass test. 7 To the best of our knowledge, data regarding the incidence of CBP in the Indian population is not known exactly.…”

Section: Discussionmentioning

confidence: 99%

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Does the four-glass test still have a place in microbiological evaluation of chronic prostatitis? Findings from an Indian tertiary care centre

Tiwari

2020

Journal of Clinical Urology

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Background: Chronic prostatitis (CP) is a bothersome disease affecting young and middle-aged men. Routine cultures often fail to localize the source of infection. Although the four-glass test is considered the gold-standard test for evaluating CP, it has found less favour in clinical practice. We re-inspected its utility in patients suffering from CP. Methods: Seventy cases of CP of Indian origin were enrolled. The four-glass test was conducted, and the samples were labelled as VB1, VB2, VB3 and EPS. A quantitative culture and drug sensitivity test for 16 antimicrobials was performed. Results: Samples from 61 patients ( Mage=36 years) were analysed. Chronic bacterial prostatitis was identified in 29 (47.5%) cases. Enterococcus spp. were the most common isolate, followed by Escherichia coli. A wide variability in positivity pattern was noted in the four-glass test. The most common pattern was for only the EPS sample to be positive (nine cases; 16.1%), followed by all four samples to be positive (seven cases; 12.5%). High susceptibility was found (94–100%) against third-generation cephalosporins, meropenem, amikacin, gentamicin and nitrofurantoin. Conclusions: The four-glass test is still important in the evaluation of CP. In about half of the cases examined in this study, bacterial localization could be made to the prostate. Level of evidence: Level IIIb.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Does the four-glass test still have a place in microbiological evaluation of chronic prostatitis? Findings from an Indian tertiary care centre

Tiwari

2020

Journal of Clinical Urology

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“…2 Heras-Cañas et al from Spain studied the microbiota of CBP, and Enterococcus faecalis and E. coli were the main etiologic agents in 37.7% and 22.2% of cases, respectively. 3 However, anaerobic bacterial species were also studied; Peptococcus, Peptostreptococcus and Propionibacterium were the primary genera detected in this article. 1 The authors of the present article collected data on both the variety of microbiota and the relationships between microbial titers and symptom severity.…”

Section: Editorial Commentmentioning

confidence: 99%

“…The present study reported that the increased microbial load detected in culture tests of CBP patients (particularly due to anaerobes) and the qualitative difference in the composition of the microbial flora affected clinical symptoms. 3 Various causative bacteria were detected as well as infections with multiple bacteria, including anaerobic bacteria, such as Peptococcus spp. and Peptostreptococcus spp.…”

Section: Editorial Commentmentioning

confidence: 99%

Editorial Comment from Dr Tsuboi et al. to Does the microbiota spectrum of prostate secretion affect the clinical status of patients with chronic bacterial prostatitis?

2021

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“…Bacterial spectrum of post-massage urine and bacteriuria levels , the dominant point of view is that a significant proportion of CBP cases are determined by uropathogens of Enterobacteriaceae 9,10. On the other hand, doubts about this are growing.…”

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confidence: 99%

Does the microbiota spectrum of prostate secretion affect the clinical status of patients with chronic bacterial prostatitis?

Kogan¹,

Naboka

Ferzauli³

et al. 2021

Int J of Urology

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To explore the influence of the microbiota of prostate secretion on the clinical status of patients with chronic bacterial prostatitis. Methods: This was an observational, single-center, comparative study. We evaluated the survey cards of 230 outpatients aged 18-45 years with a history of prostatitis from 2012 to 2019. As a result, 170 outpatients were selected for the study. All patients underwent an assessment of symptoms using International Prostate Symptom Scorequality of life, National Institutes of Health-Chronic Prostatitis Symptom Index, International Index of Erectile Function, pain visual analog scale. A bacteriological study (after the Meares-Stamey test) of post-massage urine was carried out on an extended media set. The following parameters were determined in each patient: leukocyturia and bacteriuria, serum testosterone and total prostate-specific antigen levels. Uroflowmetry, transrectal prostate ultrasound with color duplex mapping and ejaculate analysis were also carried out. Results: Aerobic-anaerobic bacterial associations were identified in all patients. Three comparison groups were identified depending on the microbiota's spectrum (in postmassage urine): aerobes prevailed in group 1 (n = 67), anaerobes prevailed in group 2 (n = 33), and the levels of aerobic and anaerobic bacteriuria were higher than ≥10 3 colony-forming units per mL in group 3 (n = 70). It was found that the severity of clinical symptoms (urination disorders, sexual dysfunction etc.) of chronic bacterial prostatitis, laboratory and instrumental changes (testosterone, prostate-specific antigen, prostate volume etc.) in groups 2 and 3 were significantly higher than in group 1. Conclusion:In patients with chronic bacterial prostatitis, a predominance of anaerobes or a combination of aerobes and anaerobes in a titer of ≥10 3 colony-forming units per mL in post-massage urine is associated with worse clinical status.

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Chronic bacterial prostatitis. Clinical and microbiological study of 332 cases

Cited by 13 publications

References 14 publications

Does the four-glass test still have a place in microbiological evaluation of chronic prostatitis? Findings from an Indian tertiary care centre

Does the four-glass test still have a place in microbiological evaluation of chronic prostatitis? Findings from an Indian tertiary care centre

Editorial Comment from Dr Tsuboi et al. to Does the microbiota spectrum of prostate secretion affect the clinical status of patients with chronic bacterial prostatitis?

Does the microbiota spectrum of prostate secretion affect the clinical status of patients with chronic bacterial prostatitis?

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