Chronic barium intoxication disrupts sulphated proteoglycan synthesis: a hypothesis for the origins of multiple sclerosis

Purdey, Mark

doi:10.1016/j.mehy.2003.12.034

Cited by 54 publications

(21 citation statements)

References 24 publications

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“…The EPA (US Environmental Protection Agency) [38] allows a maximum of 0.002 mg g −1 of Ba in drinking water. The harmful effects of ingesting low levels of Ba 2+ over long periods has not been established [33,36]; however, soluble salts of barium have proved to be harmful to animals, plants and humans [39][40][41][42]. High concentrations of Ba 2+ have been associated with multiple sclerosis and neurodegenerative diseases [39].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Ba2+ by Ca-exchange clinoptilolite tuff and montmorillonite clay

Chávez

Pablo

García

2010

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Adsorption of Ba2+ by Ca-exchange clinoptilolite tuff and montmorillonite clay

Chávez

Pablo

García

2010

Journal of Hazardous Materials

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“…2 In addition, a possible implication of Ba in the incidence clustering of multiple sclerosis through the disruption of the sulphated proteoglycan synthesis has been suggested. 3 Cesium, used on occasion in electronic and optical devices, has acquired a bad reputation because radioactive isotopes are distributed in the atmosphere by nuclear bomb tests and accidents at nuclear power plants. The chemical and physiologic properties of Cs are of interest and concern for human health.…”

mentioning

confidence: 99%

Uncertainty of inductively coupled plasma mass spectrometry based measurements: an application to the analysis of urinary barium, cesium, antimony and tungsten

Alimonti¹,

Forte²,

Spezia

et al. 2005

Rapid Comm Mass Spectrometry

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The wide use of barium (Ba), cesium (Cs), antimony (Sb) and tungsten (W) in many industrial and agricultural fields causes the increased release of these metals into the environment, laying the basis for health risk. To assess the exposure for the general population, the development of adequate and reliable analytical techniques becomes compulsory. This study refers to the quantification of urinary Ba, Cs, Sb and W levels by both quadrupole (Q) and sector field (SF) inductively coupled plasma mass spectrometry (ICP-MS). The two procedures were compared for their performances and their measurement uncertainties. The limits of detection were (Q and SF) 23.0 and 5.21 ng L(-1) for Ba; 21.1 and 7.52 ng L(-1) for Cs; 1.09 and 0.43 ng L(-1) for Sb; and 0.36 and 0.49 ng L(-1) for W. The trueness was better than 93.3% and the precision less than 12% for both techniques. Relative expanded uncertainties of the analytical procedures, at the median levels found in the general population, were below 5% for all the elements with both ICP-MS techniques. The uncertainties related to the calibration and repeatability were the parameters most influencing the final analytical performance. The urinary median values observed in healthy subjects from central Italy were 1146, 4301, 60.8 and 48.5 ng L(-1) for Ba, Cs, Sb and W, respectively.

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“…High concentration of barium has been associated with multiple sclerosis and neurodegenerative diseases (Purdey, 2004). The toxicity of barium is related to its solubility and for insoluble salts the solubility increases with decreasing pH.…”

Section: Natural Occurring Radioactive Materials (Norm)mentioning

confidence: 99%

Optimal design of adsorbents for NORM removal from produced water in natural gas fracking. Part 1: Group contribution method for adsorption

Benavides

Diwekar

2015

Chemical Engineering Science

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We applied group contribution methods (GCM) to predict specific properties of adsorbent required. We estimated the thermodynamic properties such as the activity coefficients of adsorbents based on the proposed GCM. We compare the experimental adsorption capacity and the estimated adsorption capacities from the GCM. a b s t r a c t Natural gas has become an essential energy resource in the U.S. due to the increasing demand of energy, the high oil prices, and the need of foreign oil independency. The improvement in the drilling technology has allowed the rapid expansion in gas production, especially for unconventional gas such as shale gas. Shale gas is natural gas trapped within fine-grained sedimentary rocks called shale formations. Hydraulic fracturing is used to extract natural gas from these formations. Although natural gas is cleaner-energy source than coal or oil, there is a lot of controversy due to the environmental impact related to the water consumption and treatment. Hydraulic fracturing generates significant volumes of wastewater that contain dissolved chemicals, high content of salts, and significant levels of natural occurring radioactive material (NORM). Hence, one of the biggest challenges of this industry is to develop techniques for the prevention, remediation, and appropriate disposal of NORM. The overall objective of this work is to develop and implement a novel computational tool for high-throughput screening and selection of new adsorbents for NORM removal. In the first part of this paper series, we study the adsorption theory for NORM removal and applied group contribution methods (GCMs) to predict specific properties of adsorbents based on their thermodynamics. Then, in the second part of this paper we develop a computer-aided molecular design (CAMD) framework that generates potential adsorbent candidates according to the properties developed by the GCMs.

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Chronic barium intoxication disrupts sulphated proteoglycan synthesis: a hypothesis for the origins of multiple sclerosis

Cited by 54 publications

References 24 publications

Adsorption of Ba2+ by Ca-exchange clinoptilolite tuff and montmorillonite clay

Adsorption of Ba2+ by Ca-exchange clinoptilolite tuff and montmorillonite clay

Uncertainty of inductively coupled plasma mass spectrometry based measurements: an application to the analysis of urinary barium, cesium, antimony and tungsten

Optimal design of adsorbents for NORM removal from produced water in natural gas fracking. Part 1: Group contribution method for adsorption

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