Chronic Benign Idiopathic Neutropenia in Jordanians

Jumean, Hani G.; Sudah, Ferial I.

doi:10.1159/000206841

Cited by 17 publications

(7 citation statements)

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“…The positive correlation between the monocyte and neutrophil counts in four large ethnic groups (Egyptians, Sudanese, Emiratis and Indians) supports benign rather than secondary NP, in which monocytosis is a more common finding [ 30 – 32 ]. In general, our findings agree with earlier reports of a high frequency of benign NP in children from Sudan and Jordan [ 4 , 6 ].…”

Section: Discussionsupporting

confidence: 93%

Prevalence of neutropenia in children by nationality

et al. 2016

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BackgroundA high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates.MethodsNeutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed. The subjects were enrolled in the Well-Child-Care program of Ambulatory Health Services of Emirate of Abu Dhabi, United Arab Emirates. NP was defined as a neutrophil count <1.5 × 109/L and severe NP <0.5 × 109/L.ResultsThe neutrophil counts reached a nadir in the fourth week of life and changed slightly from the age of six-months to six-years. The frequency of NP was (from West-to-East): North African Arabs 15.4 %, Green Crescent Arabs 9.8 %, Peninsular Arabs 10.9 %, Iranians 3.1 %, Afghanis 2.5 %, Pakistanis 5.6 %, Indians 10.2 %, and Filipinos 7.3 %. The frequency of severe NP in North African Arabs (Sudanese) was 2.8 %, Green Crescent and Peninsular Arabs ≤1 %, Indians 1.5 %, and Filipinos 1.8 %. In 12,703 Emirati children, the frequency of NP was 10.6 % similar to their adult counterparts.ConclusionThe prevalence of childhood NP varied considerably by geoethnicity. Measures to prevent the inappropriate investigations of healthy children with benign neutropenia are proposed.Electronic supplementary materialThe online version of this article (doi:10.1186/s12878-016-0054-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Prevalence of neutropenia in children by nationality

et al. 2016

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“…Similar findings have been reported previously in idiopathic neutropenia (Baldwin & Roath 1983), but in a group in which peripheral blood neutrophils were > 1 x 109/1 in eight of the ten patients studied. Normal marrow granulocyte reserves, an abnormality of granulocyte release, or both, have been found by others in a small number of children with benign neutropenia (Stahlie & Holland 1956, Deinard & Page 1974, Parmley et al 1981, and in the ethnic neutropenia found in Blacks (Mason, Lessin & Schechter 1979), Jordanians (Jumean & Sudah 1983), and Yemenite Jews (Mintz & Sachs 1973). Subjects in most of these reports also did not have neutropenia as severe as that in our patients.…”

Section: Resultssupporting

confidence: 77%

Bone marrow granulocyte reserve in chronic benign idiopathic neutropenia

Mant

Gordon

Akabutu

1987

Clinical &Amp; Laboratory Haematology

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Fifteen patients with chronic benign idiopathic neutropenia (CBIN) with neutrophil counts less than 1.0 X 10(9)/1 have been studied. The mean age was 33 years (range 23-50) comprising 11 females and 4 males. Bone marrow cellularity was normal except in two patients who showed slight reduction and one who had a slight increase. Bone marrow differential counts were normal apart from a small increase in the percentage of promyelocytes and reduction in the myeloid/erythroid ratio in some patients. Peripheral blood counts showed no 'compensatory' monocytosis. Epinephrine stimulation tests showed no evidence of excess neutrophil margination. After endotoxin administration there was a one- to two-fold increase in neutrophil counts in three patients, a three-fold increase in three patients and a greater than four-fold increase in the remaining nine patients. The findings suggest that the benign course of CBIN is not due to excess neutrophil margination nor to compensatory monocytosis, but that at least one mechanism includes a functionally adequate release of neutrophils to the peripheral blood under conditions of stress with subnormal delivery of neutrophils under basal conditions. The variability in responses to endotoxin suggests that CBIN is not entirely homogeneous with respect to mechanism. The findings of relatively normal bone marrow cellularity and differential counts and a normal or substantial neutrophil response to endotoxin appear characteristic. They may help predict a benign clinical course in neutropenic patients and assist diagnosis of the CBIN variant of idiopathic neutropenia.

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“…Benign ethnic neutropenia have been reported in several populations, and in particular those of African descent and in some Middle East ethnic groups [1][2][3][4][5][6][7][8]. This finding, although noteworthy, apparently does not increase the risk of infections in affected individuals [5,9].…”

Section: Introductionmentioning

confidence: 96%