Chronic bronchitis in relation to hospitalization and mortality over three decades

Pelkonen, Margit; Notkola, Irma‐Leena; Laatikainen, Tiina; Jousilahti, Pekka

doi:10.1016/j.rmed.2016.12.018

Cited by 24 publications

(19 citation statements)

References 31 publications

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“… 48 Chronic bronchitis increased all-cause mortality and mortality from respiratory causes, cardiovascular diseases, and cancer. 23 In our study, early onset patients had more frequent exacerbation and poorer health status, which could cause death at younger ages.…”

Section: Discussionmentioning

confidence: 54%

“… 21 With the progress of disease, chronic bronchitis has an increased risk for frequent exacerbation. 22 , 23 Not only did patients with chronic bronchitis have a higher frequency of exacerbation, but also had longer stays in the hospital. 23 We found that the age of onset is negatively correlated with the number of hospital admissions, which was similar to these results.…”

Section: Discussionmentioning

confidence: 99%

“… 22 , 23 Not only did patients with chronic bronchitis have a higher frequency of exacerbation, but also had longer stays in the hospital. 23 We found that the age of onset is negatively correlated with the number of hospital admissions, which was similar to these results. The earlier the onset, the more frequently these patients presented with exacerbation.…”

Section: Discussionmentioning

confidence: 99%

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The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study

Zhu

Luo

et al. 2018

COPD

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PurposeChronic bronchitis is thought to occur in elderly patients, and smoking seems to be an important risk factor. The outcomes related to the age of onset in patients with chronic bronchitis are still unclear.Patients and methodsA retrospective study was conducted on deceased patients whose diagnosis included bronchitis from 2010 to 2016. Patients were separated into two groups according to the age of onset (Group I, age ≤50 years old; Group II, age >50 years old). Information regarding disease course, smoking history, death age, number of admissions per year, Hugh Jones Index, and self-reported comorbidities of the patients was recorded.ResultsThe courses of chronic cough and sputum were 33.38±7.73 years and 14.44±8.60 years in Group I and Group II, respectively (p<0.05). The death ages of Group I and Group II were 77.65±7.87 years and 84.69±6.67 years, respectively (p<0.05). There was a significant negative correlation between the number of hospital admissions per year and the age of onset. The age of onset was negatively associated with daily smoking count (r=−0.210) and total smoking count (r=−0.146). In Group I, there were fewer cases of coronary heart disease (OR =0.41 [0.24–0.71]), neurological diseases (OR =0.48 [0.24–0.97]), and total comorbidities (OR =0.67 [0.54–0.85]) than in Group II.ConclusionPatients with early onset chronic bronchitis had a longer history, younger death age, poorer health status, and lower incidence of comorbidities.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study

Zhu

Luo

et al. 2018

COPD

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“…In the Tucson Epidemiologic Survey of Airway Obstructive Disease, younger patients with CB had a greater mortality compared to those without CB [28]. In a study of nearly 48,000 men and women, CB was associated with an increased duration of hospitalization and a greater all-cause mortality [25].…”

Section: Discussionmentioning

confidence: 97%

“…The prevalence of CB ranges anywhere from 12.2% in smokers without air ow obstruction to 74% in some COPD cohorts [20][21][22]. CB has been related to an accelerated rate of lung function decline, worse health related quality of life, increased mortality, and an increased risk of respiratory exacerbations in individuals with and without COPD [20,[23][24][25]. In the Copenhagen City Heart Study, chronic mucus hypersecretion was associated with an increased rate of FEV 1 decline over time [24].…”

Section: Discussionmentioning

confidence: 99%

Current Smoking With or Without Chronic Bronchitis is Independently Associated With Goblet Cell Hyperplasia in Healthy Smokers and COPD Subjects: an Analysis of the SPIROMICS Cohort

Kim

Jeong

Zhao

et al. 2020

Preprint

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Background: COPD, chronic bronchitis (CB) and active smoking have all been associated with large airway goblet cell hyperplasia (GCH) in small studies. Active smoking is strongly associated with CB, but there is a disconnect between CB clinical symptoms and pathology. Chronic cough and sputum production poorly correlate with the presence of GCH or COPD. We hypothesized that the primary determinant of GCH in ever smokers with or without airflow obstruction is active smoking. Methods: Goblet Cell Density (GCD) was measured in 71 current or former smokers [32 subjects without COPD and 39 COPD subjects] in which endobronchial mucosal biopsies were obtained during the SPIROMICS bronchoscopy substudy. Biopsies were stained with Periodic Acid Schiff-Alcian Blue, and GCD was measured as number of goblet cells/mm basement membrane by two independent observers in a blinded fashion. GCD was divided into tertiles (1=low, 2=medium, 3=high) based on log10 transformed values. Multivariable logistic and linear regressions were performed with CB and current smoking as the independent variables of interest and demographics and FEV1% predicted smoking as covariates.Results: Log10 GCD was greater in current smokers compared to former smokers (1.16±0.28 [n=31] vs. 0.85±0.42 [n=40], p=0.001). Those with classically defined CB had a greater log10 GCD compared to those without CB (1.21±0.31 [n=13] vs. 0.94±0.39 [n=58], p=0.024). Similarly, those with CB by the SGRQ definition had a greater log10 GCD compared to those without CB (1.13±0.39 [n=25] vs. 0.91±0.39 [n=43], p=0.028). Tertiles 2 and 3 had a greater percent of current smokers compared to tertile 1 (16.7, 50.0 and 63.6% in tertiles 1, 2 and 3, respectively, p=0.004). Current smoking was independently associated with tertile 3 (high GCD) (OR 4.15, 95% CI 1.17, 14.71) whereas CB was not in multivariable logistic regression. Similar results were found with multivariable linear regression for log10 GCD.Conclusions: GCD is higher in current smokers with and without airflow obstruction and in CB. However, current smoking, but not CB, is independently associated with GCD. These results suggest that GCH is induced by active smoke exposure and does not necessarily correlate with the clinical symptoms of CB.

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The Spectrum of Non-asthmatic Airway Diseases Contributing to Cough in the Adult

Braman

Poor

2019

Curr Otorhinolaryngol Rep

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Purpose of Review Cough becomes a pathologic reflex when the airways are inflamed and overwhelmed with excessive mucus. The goal of this review is to discuss acute and chronic cough syndromes caused by non-asthmatic airway diseases. Recent Findings Acute cough syndrome is short-lived and self-limited. Acute bronchitis and diffuse acute infectious bronchiolitis (DAIB) are examples. The former is usually caused by a viral illness; the latter by Mycoplasma pneumoniae, influenza, and Haemophilus influenzae. Causes of chronic cough in the adult include chronic bronchitis, non-infectious bronchiolitis, and noncystic fibrosis bronchiectasis. Summary Supportive measures are recommended for acute bronchitis and antibiotic use is discouraged. Antibiotics may be needed for DAIB. Smoking cessation and bronchodilators can control cough in chronic bronchitis. Therapeutic approaches for non-infectious bronchiolitis depend on the varied etiology. The hallmark of bronchiectasis is a chronic infection of the airways, and antibiotics, mucus clearance measures, and bronchodilators are all supportive.

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Chronic bronchitis in relation to hospitalization and mortality over three decades

Abstract: Symptoms of chronic bronchitis can help to identify individuals who are at risk for increased hospitalizations and mortality.

Cited by 24 publications

References 31 publications

The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study

The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study

Current Smoking With or Without Chronic Bronchitis is Independently Associated With Goblet Cell Hyperplasia in Healthy Smokers and COPD Subjects: an Analysis of the SPIROMICS Cohort

The Spectrum of Non-asthmatic Airway Diseases Contributing to Cough in the Adult

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