Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

Choi, Joon Young; Yoon, Hyoung Kyu; Park, Seoung Ju; Park, Yong Bum; Shin, Kyeong‐Cheol; Na, Ju Ock; Yoo, Kwang Ha; Jung, Ki‐Suck; Kim, Young Kyoon; Rhee, Chin Kook

doi:10.2147/copd.s105516

Cited by 9 publications

(16 citation statements)

References 30 publications

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“…Fifty-seven patients had CAT scores ≥3 (20.4%). When the CAT score cut-off was <3, the percentages of alleged patients with CB were too low compared with previously reported CB percentages, 3 so only the CB group, defined as patients with COPD with a CAT score ≥3, were evaluated in depth. Table 1 shows a comparison of the clinical characteristics of the CB and non-CB groups.…”

Section: Resultsmentioning

confidence: 96%

“… 1 Patients with CB are generally more symptomatic, with a higher COPD assessment tool (CAT) score, and have a lower quality of life, scoring higher on the total SGRQ. 2 , 3 Many studies have also shown that impaired pulmonary function is more evident for the CB type. 3 Forced expiratory volume in 1 second (FEV 1 ) and FEV 1 /forced vital capacity (FVC) are lower for the CB type.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 3 Many studies have also shown that impaired pulmonary function is more evident for the CB type. 3 Forced expiratory volume in 1 second (FEV 1 ) and FEV 1 /forced vital capacity (FVC) are lower for the CB type. 1 Exacerbations and mortality are higher in patients with the CB type.…”

Section: Introductionmentioning

confidence: 99%

“…For example, older males have difficulty understanding “2 consecutive years” and the resultant prevalence of CB in overall COPD seems to be lower than the reported prevalence worldwide in Korean patients with COPD. 1 , 3 In addition, checking whether patients have had the complaint of sputum for 3 months per year requires mental effort for older patients to recall.…”

Section: Introductionmentioning

confidence: 99%

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Alternative definitions of chronic bronchitis and their correlation with CT parameters

Lim¹,

Lee²,

Kim³

et al. 2018

COPD

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IntroductionPhenotyping of chronic bronchitis (CB) using COPD assessment tool (CAT) scores and St George’s Respiratory Questionnaire (SGRQ) has rarely been attempted. The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ. Furthermore, the predictability of CT parameters was also assessed for each CB definition.Materials and methodsPatients enrolled in the Korean Obstructive Lung Disease study from June 2005 to October 2015 were evaluated for this study. The patients were spirometrically diagnosed with COPD and had a smoking history of >10 pack-years. Volumetric CT scans were performed for each patient upon enrollment in the cohort. Two definitions of CB using CAT 1/2 scores and SGRQ questions were used to phenotype CB among the study patients. Receiver operating characteristic curve analysis was performed to estimate the predictability of CT parameters for the CB phenotypes.ResultsUsing CAT 1/2 scores, 57 of 279 (20.4%) patients had CB, and 178 of 573 (31.1%) had CB when the SGRQ questions were used to phenotype it. Total CAT and SGRQ scores were significantly higher in the CB group than those in the non-CB group for both definitions of CB. Forced expiratory volume in 1 second was lower for both CAT-defined and SGRQ-defined CB than that in the non-CB group. Mean wall thickness was significantly higher for both CB groups than in the non-CB group. Expiratory lung volume was higher and mean lung density was significantly lower for the SGRQ-defined CB group than non-CB group.ConclusionThe 2 CB definitions using CAT scores and the SGRQ questions correlated with associated CT airway parameters. SGRQ-defined CB better reflected the accompaniment of small airway obstruction when compared with CAT-defined CB.

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alternative definitions of chronic bronchitis and their correlation with CT parameters

Lim¹,

Lee²,

Kim³

et al. 2018

COPD

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“…Chronic bronchitis patients with COPD are characterized by airway wall thickening as detected via thoracic CT. 6,14 Such patients are often more symptomatic and show more frequent exacerbations compared to patients without chronic bronchitis. [24][25][26][27] Furthermore, MWA% is also correlated with small airway disease, 10 and it may also have had a detrimental effect on COPD patients with mixed phenotype. We found that frequent exacerbations in the mixed phenotype may have led to increased mortality, consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

<p>Mixed Phenotype of Emphysema and Airway Wall Thickening Is Associated with Frequent Exacerbation in Chronic Obstructive Pulmonary Disease Patients</p>

Lim¹,

Kim²,

Lim³

et al. 2019

COPD

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Objective: The presence of both emphysema and airway wall thickening determined via volumetric computed tomography (CT) is defined as mixed phenotype. The long-term clinical course of this phenotype has not been studied in depth. This study compared the mixed phenotype to other phenotypes of chronic obstructive pulmonary disease (COPD) patients. Methods: COPD patients enrolled in the Korean Obstructive Lung Disease (KOLD) study from June 2005 to October 2015 were evaluated. The emphysema index and the percentage of bronchial mean wall area were calculated from volumetric CT scans. Patients with COPD were classified into four phenotypes using two cutoffs: emphysema index of 15% and median value of mean wall area (MWA%). Results: Of 435 patients with COPD, 99 (22.8%) were defined as CT-normal type, 119 (27.4%) as emphysema-dominant type, 113 (26.0%) as airway-dominant type, and 104 (23.9%) as mixed type. The mixed phenotype showed the highest baseline total COPD Assessment Test (CAT) and St. George's Respiratory Questionnaire (SGRQ) scores. Moreover, it had the highest proportion of patients experiencing exacerbation of COPD (50.0%), and had the lowest baseline FEV1. Lower BMI, GOLD stages III-IV, and mixed phenotype were significant factors associated with severe exacerbation frequency in univariate analyses. Multivariate analyses showed that lower BMI and CT phenotype were significant factors associated with severe exacerbation frequency. Compared to the CT-normal phenotype, the mixed phenotype was significantly associated with more frequent severe exacerbation (IRR 4.134, P=0.031). Conclusion: Patients with mixed phenotype are more symptomatic, have poorer pulmonary function, and are associated with more frequent severe exacerbation. Plain Language SummaryPatients with mixed phenotype of emphysema and airway wall thickening are more symptomatic, have poorer pulmonary function, and are associated with more frequent severe exacerbation.

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Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort

Choi

Kim

et al. 2022

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

Cited by 9 publications

References 30 publications

Alternative definitions of chronic bronchitis and their correlation with CT parameters

Alternative definitions of chronic bronchitis and their correlation with CT parameters

<p>Mixed Phenotype of Emphysema and Airway Wall Thickening Is Associated with Frequent Exacerbation in Chronic Obstructive Pulmonary Disease Patients</p>

Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort

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