Chronic caffeine consumption improves the acute sleep deprivation‐induced spatial memory impairment while altering N‐methyl‐D‐aspartate receptor subunit expression in male rats

Keloğlan, Seval; Şahin, Leyla; Cevik, Özge Selin

doi:10.1002/jdn.10212

Cited by 4 publications

(5 citation statements)

References 58 publications

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“…In our study, there was a decrease in the Cf group, but it was not significant. In our previous study, Cf did not affect BDNF and NR2A levels in the hippocampus, and a decrease was found in NR2B, but it was not significant (Keloglan‐Musuroglu et al, 2022). In a study was found that BDNF increased with age and Cf solution (0.1 mg/mL) during 30 consecutive days prevented this increase (Sallaberry et al, 2013).…”

Section: Discussionmentioning

confidence: 81%

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Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

Musuroglu Keloglan,

Sahin,

Kocahan

et al. 2023

Intl J of Devlp Neuroscience

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BackgroundCaffeine (Cf) antagonizes the adenosine receptors and has neuroprotective properties. The effect of Cf has been seen on stress‐induced deficits of cognitive. In this study, we have investigated the effect of Cf on learning and memory functions induced by social isolation (SI) stress.Materials and methodsIn the present study, 21‐day‐old Wistar albino male rats (n = 28) were divided into four groups: the control (C), the SI, the Cf, and the social isolation + caffeine (SICf). Cf (0.3 g/L) was added to the drinking water of the experimental animals for 4 weeks. The learning and memory functions were assessed using the Morris Water Maze Test (MWMT). Following, was performed histopathological evaluation and determined hippocampal gene expression levels by RT‐qPCR.ResultsAccording to MWMT findings, the time spent in the quadrant where the platform removed was decreased in the SI group compared with the C (p < 0.05). Histological evaluation showed morphological changes in SI by irregular appearance, cellular edema, and dark pycnotic appearance of nuclei in some neurons. However, it was observed that the histological structure of most of the neurons in the SICf group was similar to the C and Cf groups. Hippocampal SNAP25 expression was decreased in the Cf and SICf groups than in the C group (p < 0.05). The GFAP expression was increased in the SICf group than in the C group (p < 0.05). NR2A increased in the SI and SICf groups compared with C and Cf groups (p < 0.05). NR2B expression decreased in the Cf group compared with C and SI groups (p < 0.05).ConclusionsSI impaired spatial memory and causes morphological changes in adolescent rats, but this effect of isolation was not seen in Cf‐treated animals. The effects of SI on NR2A, Cf on NR2B, and SNAP25 are remarkable. Here, we propose that the impaired effect of SI on spatial memory may be mediated by NR2A, but further studies are needed to explain this effect.

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Section: Discussionmentioning

confidence: 81%

“…Cf (Sigma Aldrich, Saint Louis, MO) was added to the drinking water of the Cf and SICf groups at a daily of 0.3 g/L for 4 weeks (Alkadhi & Alhaider, 2016; Keloglan‐Musuroglu et al, 2022). The estimated amount of Cf that each rat consumed per day was 1–2 mg/kg.…”

Section: Methodsmentioning

confidence: 99%

Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

Musuroglu Keloglan,

Sahin,

Kocahan

et al. 2023

Intl J of Devlp Neuroscience

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“…Sleep deprivation also alters the expression of NMDA receptors in the hippocampus. Brief sleep restriction increases the NR2A subunit of NMDA receptors, changing the NR2A/NR2B ratio and impacting hippocampal LTP 80 . While alterations can be reversed with sleep recovery, the long‐term effects of prolonged sleep restriction remain unclear.…”

Section: The Potential Mechanisms Driving Sd‐induced Pndmentioning

confidence: 99%

“…Brief sleep restriction increases the NR2A subunit of NMDA receptors, changing the NR2A/NR2B ratio and impacting hippocampal LTP. 80 While alterations can be reversed with sleep recovery, the long‐term effects of prolonged sleep restriction remain unclear. Additionally, sleep deprivation significantly reduces the expression and phosphorylation levels of glutamate receptors in the posterior hippocampus, weakening glutamate signaling and affecting LTP.…”

Section: The Potential Mechanisms Driving Sd‐induced Pndmentioning

confidence: 99%

The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review

Chen,

Zhai,

Lan

et al. 2024

Ibrain

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This review comprehensively assesses the epidemiology, interaction, and impact on patient outcomes of perioperative sleep disorders (SD) and perioperative neurocognitive disorders (PND) in the elderly. The incidence of SD and PND during the perioperative period in older adults is alarmingly high, with SD significantly contributing to the occurrence of postoperative delirium. However, the clinical evidence linking SD to PND remains insufficient, despite substantial preclinical data. Therefore, this study focuses on the underlying mechanisms between SD and PND, underscoring that potential mechanisms driving SD‐induced PND include uncontrolled central nervous inflammation, blood–brain barrier disruption, circadian rhythm disturbances, glial cell dysfunction, neuronal and synaptic abnormalities, impaired central metabolic waste clearance, gut microbiome dysbiosis, hippocampal oxidative stress, and altered brain network connectivity. Additionally, the review also evaluates the effectiveness of various sleep interventions, both pharmacological and nonpharmacological, in mitigating PND. Strategies such as earplugs, eye masks, restoring circadian rhythms, physical exercise, noninvasive brain stimulation, dexmedetomidine, and melatonin receptor agonists have shown efficacy in reducing PND incidence. The impact of other sleep‐improvement drugs (e.g., orexin receptor antagonists) and methods (e.g., cognitive‐behavioral therapy for insomnia) on PND is still unclear. However, certain drugs used for treating SD (e.g., antidepressants and first‐generation antihistamines) may potentially aggravate PND. By providing valuable insights and references, this review aimed to enhance the understanding and management of PND in older adults based on SD.

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“…Caffeine is an anhydrous form (Sigma Aldrich, Saint Louis, MO, USA, lot: r068K8730V) was administered via drinking water (0.3 g⁄L) chronically for 4 weeks and prepared daily [19,20]. The daily consumption of caffeine by each rat was ensured to be nearly 16-20 mg.…”

Section: Caffeine Treatmentmentioning

confidence: 99%

Effect of caffeine supplementation during treadmill exercise on hippocampal genes expression levels in adolescent rats

BAKIR>

Cevik

Keloğlan

et al. 2023

The European Research Journal

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Objectives: The usage of caffeine, a psychostimulant that is included in many foods and drinks, is rising, especially among young people. Also, caffeine works as an ergogenic substance during exercise to improve performance, and strength. In this study, our aim was to investigate the effect of caffeine consumption and exercise on hippocampal learning and memory functions in early life. Methods: Postnatal 28 days old Wistar albino male rats (n = 28) were randomly divided into 4 groups; control group (C), caffeine group (Cf), exercise group (E), caffeine+exercise group (CfE). Caffeine was dissolved in drinking water (0.3 g/L) and the treadmill exercise was applied 3 days a week. Following, the rats were applied to Morris Water Maze Test (MWMT) and open field test. N-methyl-D-aspartate (NMDA) receptors NR2A, NR2B, and brain-derived neurotrophic factor (BDNF) gene expression levels were investigated in hippocampus tissue by RT-PCR. Results: In MWMT, there was no significant difference in terms of learning and memory functions and hippocampal gene expression levels of the groups (p > 0.05). In the open field test, the time spent in the center was decreased in the CfE group, and the number of entries to the center was decreased in the E and CfE groups compared to the control group (p < 0.05). Conclusions: We assumed that caffeine given with exercise application caused anxiety behavior but did not affect learning and memory. There is a need for new studies investigating the effect of caffeine on exercise with different doses and durations depending on age.

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Chronic caffeine consumption improves the acute sleep deprivation‐induced spatial memory impairment while altering N‐methyl‐D‐aspartate receptor subunit expression in male rats

Cited by 4 publications

References 58 publications

Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review

Effect of caffeine supplementation during treadmill exercise on hippocampal genes expression levels in adolescent rats

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