Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations

Derise, Allison; Ford, Carey L.; Hafiz, Nazar; Pandit, Sudha; Vyas, Aditya; Igbinedion, Samuel; Morris, James; Jordan, Paul; Cai, Quiang; Alexander, Jonathan

doi:10.3390/pathophysiology29020018

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…This drug increases the entry of extracellular calcium into the cytoplasm by potentiating the acinar cell response to ATP mediated by receptors expressed on acinar cells. This significant alteration of calcium causes the opening of chloride channels thereby increasing salivary secretion (20).…”

Section: Discussionmentioning

confidence: 99%

The relationship between smoking status and salivary flow rate in inhaled general anesthesia patients at Brebes Regional Hospital

Nabitha,

Suandika,

Susanto

et al. 2023

RIK

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Background :Smoking is one of the habits that is inherent in humans because it is addictive. Active smokers in Indonesia have increased significantly in 10 years. Smoking has a negative impact on health, one of which is changes in salivary flow rate. Changes in salivary flow rate in smokers can cause complications in the airway when performing surgery using inhalation general anaesthesia. The purpose of this study was to determine the relationship between smoking status and salivary flow rate in patients with inhalation general anaesthesia. Method : This type of research is observational analytic with a cross sectional approach. The sample in the study was 35 respondents with 4 inclusion criteria. The sample in this study was taken with purporsive sampling technique. Data collection stimulated saliva by suction method. Data analysis using univariate and bivariate analysis, namely the Chi-Square test. Results : The results showed that inhalation general anaesthesia patients were more smokers with 24 respondents (68.6%) and respondents who experienced changes in salivary flow rate obtained the most respondents who experienced hypersaliva as many as 15 respondents (42.9%). The results of bivariate analysis using the Chi-Square test showed that 11 respondents (31.4%) who smoked experienced hypersaliva with a p-value of 0.000 <0.05. Conclusion : There is a relationship between smoking status and salivary flow rate in inhalation anaesthesia patients, namely the increase in salivary flow rate in smoking respondents with inhalation general anaesthesia.

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Section: Discussionmentioning

confidence: 99%

The relationship between smoking status and salivary flow rate in inhaled general anesthesia patients at Brebes Regional Hospital

Nabitha,

Suandika,

Susanto

et al. 2023

RIK

View full text Add to dashboard Cite

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Cannabis Users Require More Anesthetic Agents for General Anesthesia in Ambulatory Oral and Maxillofacial Surgery Procedures

Ripperger,

Atte,

Ritto

2023

Journal of Oral and Maxillofacial Surgery

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Features of Anesthesia in Patients With Special Needs. Part 1

KRAVETS,

KLYGUNENKO,

YEKHALOV

et al. 2024

Pain Anaesth Int Care

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The non-medical use of cannabis can negatively impact the morpho-functional state of almost all organs and systems of the human body. During acute intoxication and established drug dependence, it can unevenly distort the effects of drugs for local and general anesthesia, leading to life-threatening complications. Part 1 of this review presents the results of acute and chronic cannabis use on homeostasis. Cerebral vasospasm and atherosclerosis are identified as major etiological factors for cannabis-related cerebrovascular diseases. Young to middle-aged individuals (30–50 years), male gender (male-to-female ratio 3.7:1), and chronic use (86%) are significant independent predictors of neurovascular toxicity, cerebral hypoperfusion, and stroke. Cannabis smoking causes damage to the respiratory mucosa similar to tobacco. Regular cannabis smokers can expect irritation of the upper respiratory tract, swelling, obstruction, chronic cough, bronchitis, lung emphysema, and bronchospasm. Some reports advocate the use of dexamethasone during surgery to alleviate these symptoms. The detrimental effects of chronic cannabis use on liver and kidney functions are somewhat overstated. Disturbances in immune system, thermoregulation, blood clotting, and carbohydrate metabolism in the absence of anesthetic precautions can significantly complicate the patient's condition in the perioperative period. Cannabinoids can interact with drugs from various groups. Awareness of the pathophysiological and biochemical consequences of cannabis use allows anesthesiologists to anticipate and effectively manage perioperative complications in this patient category

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Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations

Cited by 4 publications

References 32 publications

The relationship between smoking status and salivary flow rate in inhaled general anesthesia patients at Brebes Regional Hospital

The relationship between smoking status and salivary flow rate in inhaled general anesthesia patients at Brebes Regional Hospital

Cannabis Users Require More Anesthetic Agents for General Anesthesia in Ambulatory Oral and Maxillofacial Surgery Procedures

Features of Anesthesia in Patients With Special Needs. Part 1

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