Chronic cassava meal modulates body weight, histology and weight of reproductive organs in male albino rats

Egbune, Olisemeke U.; Egbune, Egoamaka O.; Orororo, Osuvwe C.; Ezedom, Theresa; Onojakpor, Ogheneyoma; Sabo, Ahmed M.; Amadi, Kemakolam

doi:10.1007/s13530-023-00179-4

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…Given that fish are harmed in terms of number, location, and size, they are among the creatures most negatively impacted by hazardous chemicals found in cassava effluents, particularly hydrogen cyanide. Additionally, they have the capacity to accumulate these substances, which eventually make their way into human bodies through the food chain [14,15]. Cassava peelcontaining wastewaters serve as breeding grounds for mosquitoes and flies, which are disease vectors, and they also contribute to the production of hydrogen cyanide in water [16].…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Effects of Cassava Effluent on the Expression of Selected Genes in the African Catfish, Clarias gariepinus

Olorunfemi,

Oteri,

Orororo

et al. 2024

JABB

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Aim: A cause for worry is the wastewater that is released into the environment or public sewers without any sort of purpose during the processing of Manihot esculenta Crantz. Fish and other aquatic species may suffer negative consequences if wastewater is discharged into streams and rivers, either directly or indirectly. This study was conducted to examine the effects of cassava effluents on gene expression in the African catfish (Clarias gariepinus). Methodology: C. gariepinus juveniles were exposed to 0.1, 0.5, 1.0 and 1.5 % concentrations of cassava effluent, respectively. The subsequent tissue extraction, RNA isolation, cDNA synthesis and electrophoresis analysis were all done following standard procedures. Results: From the results obtained, there were varying levels of upregulation in the expression levels of all the nine genes assessed: IL-1β, CYPIIA, HSP70, DMRTI, HSD17B, FOX12, MEL1C, CAMKIIg and GH genes. Statistical analysis to compare the expression levels of the genes at the different concentrations with their corresponding control experiments showed that the upregulation of only two genes, (HSD17B and GH), upon exposure to cassava effluents were not significant (p >0.05) at any concentration. The upregulation of the seven other genes is an indication that the cassava effluents exerted adverse impacts on the physiology of C. gariepinus. Conclusion: It is therefore recommended that cassava effluents be properly treated before being discharged into the aquatic environment.

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Section: Introductionmentioning

confidence: 99%

Genotoxic Effects of Cassava Effluent on the Expression of Selected Genes in the African Catfish, Clarias gariepinus

Olorunfemi,

Oteri,

Orororo

et al. 2024

JABB

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“…Nigella sativa L. also known as black cumin or black seed, and Syzygium Cumini L. also known as Java Plum, respectively, are two of these plants that have a lot of extremely promising health benefits. Due to their effects in minimizing oxidative stress and the apoptotic cascade, as well as in reducing kidney damage biomarkers and histological features, they are widely recognized as a realistic option for combating nephron-toxicants (Hosseinian et al, 2018;Hossain et al, 2017;Egbune et al, 2023). Due to the significant amount of phytochemicals in these plants' seeds, researchers are attempting to support their alleged usefulness in treating renal failure.…”

Section: Introductionmentioning

confidence: 99%

Effects of Nigella Sativa and Syzygium Cumini Seed Extracts on Blood Glucose Levels in Swiss Albino Mice

Tufael,

Sayed Eqramul Hasan,

Arafath Jubayer

et al. 2023

JKLST

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A Swiss Albino mouse model was used to study the effects of two species that are common in Bangladesh: Nigella Sativa L. and Syzygium Cumini L. The trial looked at how a blend of methanol extracts from Syzygium Cumini L. and Nigella Sativa L. affected blood sugar levels using the oral glucose tolerance test (OGTT). 40 overnight starved mice were divided into eight groups with a 4:1 male to female ratio. After 120 minutes of glucose injection, blood glucose levels were measured using a glucometric method. However, the mean values of the samples that were only treated with high doses of Syzygium Cumini L. (Group 1) and Nigella Sativa L. (Group 2) were 3.92 mmol/l and 3.8 mmol/l, respectively. Group-5 low dose (50 mg/kg) treated mean value was 4.02 mmol/l, group-6 moderate dose (100 mg/kg) treated mean value was 3.7 mmol/l, group-7 poly medium dose (200 mg/kg) treated mean value was 3.38 mmol/l, and group-8 poly high dose (400 mg/kg) treated mean value was 3.12 mmol/l where combined extract formulations were used. The combined formulation of the methanol extract of Nigella Sativa L. (Seed) and Syzygium Cumini L. (Seed) possesses significant oral hypoglycemic activity at different time intervals in the cases when compared to Control mean value, showing that all doses given significantly reduced blood sugar level

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Solid-state fermentation of cassava (Manihot esculenta Crantz): a review

Egbune,

Ezedom,

Orororo

et al. 2023

World J Microbiol Biotechnol

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Chronic cassava meal modulates body weight, histology and weight of reproductive organs in male albino rats

Cited by 3 publications

References 50 publications

Genotoxic Effects of Cassava Effluent on the Expression of Selected Genes in the African Catfish, Clarias gariepinus

Genotoxic Effects of Cassava Effluent on the Expression of Selected Genes in the African Catfish, Clarias gariepinus

Effects of Nigella Sativa and Syzygium Cumini Seed Extracts on Blood Glucose Levels in Swiss Albino Mice

Solid-state fermentation of cassava (Manihot esculenta Crantz): a review

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